Metformin

This cheap pill might help you live a longer, healthier life
Metformin as Anti-Aging Therapy: Is It for Everyone?: Trends in Endocrinology & Metabolism
Full title: High glucose protects mesenchymal stem cells from metformin-induced apoptosis through the AMPK-mediated mTOR pathway | Scientific Reports
Diabetes drug has unexpected, broad implications for healthy aging
Mitochondrial targets of metformin-Are they physiologically relevant? – PubMed – NCBI
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy: Cell
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus | Nature Reviews Endocrinology
H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses | Cell Death & Disease
Pro-neurocognitive and Anti-sarcopenic benefits of one-year Metformin therapy in ovariectomized aged mice. – PubMed – NCBI

Risks: this risk is low (less than 10 cases for 100,000 patient years), but the risk of metformin-induced lactic acidosis (MALA) increases in certain situations where both the plasma levels of metformin are increased and lactate clearance is impaired.[6] 

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