Category: Pain and Inflammation

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Selective activation of G?ob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression | Nature Communications

Selective activation of G?ob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression | Nature Communications

We have discovered that the A1R-selective agonist, benzyloxy-cyclopentyladenosine (BnOCPA), is a potent and powerful analgesic but does not cause sedation, bradycardia, hypotension or respiratory depression. This unprecedented discrimination between native A1Rs arises from BnOCPA’s unique and exquisitely selective activation of Gob among the six G?i/o subtypes, and in the absence of ?-arrestin recruitment.

https://www.nature.com/articles/s41467-022-31652-2

Western high-fat diet can cause chronic pain, according to new study — ScienceDaily

Western high-fat diet can cause chronic pain, according to new study — ScienceDaily

In the new paper, Dr. Boyd and his colleagues used multiple methods in both mice and humans to study the role of polyunsaturated fatty acids in pain conditions. They found that typical Western diets high in omega-6 polyunsaturated fats served as a significant risk factor for both inflammatory and neuropathic pain.

https://www.sciencedaily.com/releases/2021/06/210623141644.htm