Tag: IG

Frontiers | Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile | Physiology

Frontiers | Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile | Physiology


” Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-glycosylation of immunoglobulin G (IgG) and total plasma proteins was previously shown to reflect changes in inflammatory pathways, which could provide valuable information to further clarify exercise effects. In order to further expand the understanding of the relationship between physical activity and inflammation, we examined the effect of intense exercise, in the form of repeated sprint training (RST), on IgG and total plasma proteins N-glycosylation in combination with traditionally used inflammation markers: C-reactive protein (CRP), interleukin 6 (IL-6), and leukocyte count.

https://www.frontiersin.org/articles/10.3389/fphys.2019.01522/full?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Frontiers | Intense physical exercise induces an anti-inflammatory change in IgG N-glycosylation profile | Physiology

Frontiers | Intense physical exercise induces an anti-inflammatory change in IgG N-glycosylation profile | Physiology

“Observed changes show the potential of intense physical exercise to reduce levels of systemic basal inflammation as well as the potential for IgG N-glycosylation to serve as a sensitive longitudinal systemic inflammation marker.”

https://www.frontiersin.org/articles/10.3389/fphys.2019.01522/abstract

Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension | Circulation

Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension | Circulation

Hyposialylated IgG and FcγRIIB in endothelium are critically involved in obesity-induced hypertension in mice, and supportive evidence was obtained in humans. Interventions targeting these mechanisms, such as ManNAc supplementation, may provide novel means to break the link between obesity and hypertension.

Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension | Circulation