Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment – Quarles – – Aging Cell – Wiley Online Library

“In this report, we demonstrate that the rapamycin‐dependent improvement of diastolic function is highly persistent, while decreases in both cardiac hypertrophy and passive stiffness are substantially persistent 8 weeks after cessation of an 8‐week treatment of rapamycin in both male and female 22‐ to 24‐month‐old C57BL/6NIA mice.”

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13086