” RESULTS

Writhing

In the acetic acid assay, a strong, dose-dependent reduction of movements was seen in BPC 157-treated animals (Figure 1). BPC 157 also seemed to be effective in reducing magnesium sulphate-induced movements, particularly when given with the challenge. The pentadecapeptide itself does not induce any writhing.

Tail pinching test

In the 90 minute study, both aspirin and BPC 157 increased the number of non-responding mice, and prolonged the time taken before a response was made. Moreover, compared with aspirin, the BPC 157 effect was more pronounced (Figure 2). This effect was not present 24 h thereafter (data not shown).

Hot-plate test

Unlike morphine, no effect was noted for BPC 157 in normal mice. However, when given to capsaicin-treated rats, BPC 157 given either as pretreatment or once daily for 14 days after capsaicin reduced the capsaicin-allodynia (Figure 3). This effect could not be obtained when BPC 157 was given only on the 14th day after capsaicin treatment. “

SikiriĆ, P., Gyires, K., Seiwerth, S., GrabarevlĆ, Z., RuČman, R., Petek, M., … Bura, M. (1993). The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology, 2(2), 121–127. doi:10.1007/bf02659088

https://sci-hub.tw/10.1007/bf02659088