Category: eli5 – explain it like I’m five

eli5 is an internet meme meaning, explain it like I’m five. We break down the science into a more digestible format to help you develop the knowledge to dig deeper into the technical publications.

These articles are the perfect place to start if you are new to all of this.

Health Hacker Australia > Articles > eli5 - explain it like I'm five

Consumer trends during Covid-19

Some interesting and somewhat encouraging news from the Woolworths CEO today via his email updates during Covid-19 show some interesting trends in consumer spending on food and vitamins during this time.

To quote from his email:

We are becoming healthier and more adventurous in our cooking
While the slow cooking movement continues, we’re also becoming increasingly adventurous. Ingredients such as cardamom, saffron and dried sesame seeds have doubled in sales. Roasted peppers are up 65%, Asian and hot chilli sauces are both up 40% and capers are up 35%.

We’re also well into soup season. What’s interesting this year is the explosive growth of dried soup mix packets (up 200%) as people make more warming soup at home.

It’s also interesting to see customers think about their health, with a big rise in vitamin sales, plus ground ginger and turmeric sales up 120% and sauerkraut up 76%. On a related topic, sales of cough and cold products are much lower this year compared to last year.”

This is encouraging and hopefully a sign that the general population is starting to become more interested in preparing fresh meals rather than fast food, and hopefully the rise in vitamins and other beneficial products is a sign that people are starting to see value in improving their health and eating better.

It’s pretty clear that the more fit and healthy you are and the better you eat, the less likely you are to contract Covid-19 and, less likely to have severe complication if you do. We have been keeping an eye on developments and have been hoping that the silver lining from all of this may be a new focus on health and well-being.

So please ensure you take some time out of your busy life to focus on whats really important, your life! We at Health Hacker wish all of you good health and encourage you to keep exploring and trying to improve your diet and lifestyle as much as possoble. Remember, something is better than nothing so start on somethign today!

What lifestyle changes will help me live longer and healthier?

We’ve previously spoken about how we might introduce foods and supplements to our diet to improve health span and lifespan. Here we explore activities and other therapies that show potential in living healthier and longer. We also explore things you perhaps should stop doing to improve health and longevity.

Mitochondrial support

Mitochondria are organelles, basically, little functional units within cells, much like an organ is to our body. They provide power to our cells by delivering ATP to the cells and are thought to once be free-ranging bacteria. It is thought that the break down of mitochondrial function is one of, if not the main contributor to aging.

Continue reading “What lifestyle changes will help me live longer and healthier?”

Which supplements can help me live longer and healthier?

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

Continue reading “Which supplements can help me live longer and healthier?”

Eating to live…longer and healthier.

There are two main ways to provide the nutrients and the myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to use supplements and the other is to do it via food in our diet.

Here, in the first of our three part series on direct action for longevity, we explore the foods you can incorporate into your diet to get those identified goodies that keep us healthy for longer. We will also include herbs here as food as they require little to no handling to be beneficial and can be consumed as a food. Some of this is known via human clinical trial while some may be a mix of anecdotal use or animal studies. In all cases we take a can’t hurt, might help, approach and will either call out or exclude anything showing any risk of harm.

It’s important to note that, while all care is taken, we cannot guarantee the accuracy of this information and you should consult your health care professional before making changes in your diet and lifestyle.

Continue reading “Eating to live…longer and healthier.”
Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to as the powerhouse of the cell due to a central role in energy production. However, modern-day mitochondria are recognized as key players in eukaryotic cell biology and are known to regulate crucial cellular processes, including calcium signalling, cell metabolism and cell death, to name a few. In this review, we will discuss foundational knowledge in mitochondrial biology and provide snapshots of recent advances that showcase how mitochondrial function regulates other cellular responses.

https://royalsocietypublishing.org/doi/full/10.1098/rsob.190126?utm_source=researcher-app&utm_medium=researcherad&utm_campaign=DVaughan_Promotedpaper_190126&utm_content=Paper

Mitochondria: Exploring 5 Lifestyle Habits to Benefit Cell Health

Mitochondria: Exploring 5 Lifestyle Habits to Benefit Cell Health

In each of our cells are small energy generators called mitochondria. The health of our mitochondria determines the amount of adenosine triphosphate (ATP) they can produce from the calories we eat and oxygen we consume. Without robust mitochondria, cells cannot do as much work as they’re capable of and we need them to do so we can stay healthy. To achieve higher levels of performance we must optimize our mitochondria, the powerhouse of our cells, to produce energy. Cell function isn’t always the first place biohackers and nootropics enthusiasts start because it is challenging to notice a subjective boost in our mitochondrial function. Whether we can detect enhanced mitochondria subjectively or not, the science is pretty clear that healthy mitochondria play a role in supporting all indicators of cognition, physical performance, and aging. In a series of comprehensive posts, we will introduce scientifically-backed lifestyle changes and nootropics that up-regulate your mitochondrial function. In our last post, we went over how to use light and temperature to boost mitochondria. Now let’s tackle 5 more lifestyle habits we can implement to achieve healthier mitochondria.

Mitochondria: Exploring 5 Lifestyle Habits to Benefit Cell Health

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?† | Open Biology

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?† | Open Biology

“The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and proliferation. The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour suppressor. AMPK can also be switched on by increases in intracellular Ca2+, by glucose starvation and by DNA damage via non-canonical, AMP-independent pathways. Genetic studies of the role of AMPK in mouse cancer suggest that, before disease arises, AMPK acts as a tumour suppressor that protects against cancer, with this protection being further enhanced by AMPK activators such as the biguanide phenformin. However, once cancer has occurred, AMPK switches to being a tumour promoter instead, enhancing cancer cell survival by protecting against metabolic, oxidative and genotoxic stresses. Studies of genetic changes in human cancer also suggest diverging roles for genes encoding subunit isoforms, with some being frequently amplified, while others are mutated.”

https://royalsocietypublishing.org/doi/10.1098/rsob.190099?utm_source=researcher-app&utm_medium=researcherad&utm_campaign=DVaughan_Promotedpaper_190099&utm_content=Paper

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

“Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to as the powerhouse of the cell due to a central role in energy production. However, modern-day mitochondria are recognized as key players in eukaryotic cell biology and are known to regulate crucial cellular processes, including calcium signalling, cell metabolism and cell death, to name a few. In this review, we will discuss foundational knowledge in mitochondrial biology and provide snapshots of recent advances that showcase how mitochondrial function regulates other cellular responses.”

https://royalsocietypublishing.org/doi/full/10.1098/rsob.190126?utm_source=researcher-app&utm_medium=researcherad&utm_campaign=DVaughan_Promotedpaper_190126&utm_content=Paper