Category: Supplements

Supplements are compounds and molecules we add to our diet/body to improve health. These are sometimes derived from foods and plants or sometimes synthesised in a lab.

Which supplements can help me live longer and healthier?

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

Continue reading “Which supplements can help me live longer and healthier?”
NMN – Nicotinimide Mononucleotide

NMN – Nicotinimide Mononucleotide

MIB-626, the NAD+ precursor that’s superior to NMN
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
The elusive NMN transporter is found | Nature Metabolism
David Sinclair – Can NMN Reverse Aging? – YouTube
Effect of “Nicotinamide Mononucleotide” (NMN) on Cardiometabolic Function – Full Text View – ClinicalTrials.gov
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
Resveratrol

Resveratrol

Trans-Resveratrol
Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More
Exploring the effect of fasting on age-related diseases — ScienceDaily
Metformin

Metformin

This cheap pill might help you live a longer, healthier life
Metformin as Anti-Aging Therapy: Is It for Everyone?: Trends in Endocrinology & Metabolism
Full title: High glucose protects mesenchymal stem cells from metformin-induced apoptosis through the AMPK-mediated mTOR pathway | Scientific Reports
Diabetes drug has unexpected, broad implications for healthy aging
Mitochondrial targets of metformin-Are they physiologically relevant? – PubMed – NCBI
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy: Cell
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus | Nature Reviews Endocrinology
H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses | Cell Death & Disease
Pro-neurocognitive and Anti-sarcopenic benefits of one-year Metformin therapy in ovariectomized aged mice. – PubMed – NCBI

Risks: this risk is low (less than 10 cases for 100,000 patient years), but the risk of metformin-induced lactic acidosis (MALA) increases in certain situations where both the plasma levels of metformin are increased and lactate clearance is impaired.[6]