“Highlights

•The first study to assess the role of oral zinc supplementation in pediatric β-TM patients with DM.

•Zinc decreased hemolysis and iron burden.

•Zinc decreased FBG and HOMA-IR while increased fasting C peptide.

•Oral zinc improved glycemic control and decreased urinary albumin excretion.

•No adverse reactions were observed due to zinc supplementation.”

Zinc supplementation improves glucose homeostasis in patients with β-thalassemia major complicated with diabetes mellitus: A randomized controlled trial – ScienceDirect