“Oleic acid affected the methylation of Pparγ and C/ebpα promoters, what correlated with higher expression. Furthermore, examined free fatty acids influenced the phenotype of mature adipocytes, especially insulin signaling pathway and adipokine secretion.”
Highlights
• SWS suppression during nighttime sleep leads to a significant increase in salivary melatonin.
• Elevated melatonin appears to play a key role in glucose tolerance changes after disturbed sleep.
• Melatonin’s effect on morning glucose tolerance depends on its secretion timing.
• Durations of REM sleep and nocturnal awakenings appear to play an important role in melatonin secretion and glucose tolerance.
• Glucose tolerance is associated with the total duration of undisturbed sleep and the length of REM sleep rather than the amount of SWS.
https://www.sciencedirect.com/science/article/abs/pii/S1389945719316405