Numerous anecdotal reports suggest that repeated use of very low doses of lysergicacid diethylamide (LSD), known as “microdosing,†improves mood and cognitive function.These effects are consistent both with the known actions of LSD on serotonin receptors,and with limited evidence that higher doses of LSD (100-200 μg) positively bias emotionprocessing. Yet, the effects of such sub-threshold doses of LSD have not been testedin a controlled laboratory setting. As a first step, we examined the effects of singlevery low doses of LSD (0 – 26μg) on mood and behavior in healthy volunteers underdouble-blind conditions.
