Emodin-induced (HeShouWu) autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes. – PubMed – NCBI

Health Hacker Australia > The Science > Ageing, Longevity and disease. > Emodin-induced (HeShouWu) autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes. – PubMed – NCBI

Emodin significantly inhibited the viability of and induced apoptosis in L02 cells in a dose- and time-dependent manner. In addition, emodin increased the number of GFP-LC3 puncta in L02 cells and upregulated the expression of LC3B-II compared to those in control cells. Furthermore, emodin significantly decreased the expression of p-PI3K, p-AKT and p-mTOR in a dose-dependent manner compared to that in control cells without altering the expression of PI3K, AKT and mTOR. Notably, cotreatment with emodin and 3-methyladenine (3-MA) or rapamycin significantly increased and decreased the apoptosis rate of L02 cells, respectively, compared to that of cells treated with emodin alone.

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes. – PubMed – NCBI

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