Highlights
• NAD+ plays an important protective role in some age-related degenerative disease states.

• NAD+ can improve mitochondrial function and maintain sufficient levels of ATP.

• NAD+ can influences DNA repair, and immune and longevity processes.

• Raising NAD+ levels can balance energy needs with supply and protect against oxidative damage and inflammation.

• Further clinical trials are necessary to validate NAD+ therapy in ageing and disease.

https://www.sciencedirect.com/science/article/pii/S0531556519307582