Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan – ScienceDirect

Health Hacker Australia > The Science > Ageing, Longevity and disease. > Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan – ScienceDirect
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Highlights
• The kynurenine pathway has recently been identified as a promising target to increase healthy longevity.

• Targeted inhibition of kynurenine pathway activity may alleviate several pathological conditions and promote healthspan.

• Changes to the production and recycling of NAD+ is a likely mediator of the beneficial effects of kynurenine pathway interventions.

• Mitochondrial function and dynamics represent NAD+-dependent processes downstream of kynurenine metabolism that may mediate benefits during aging.

https://www.sciencedirect.com/science/article/pii/S053155651930765X

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