Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell

Health Hacker Australia > The Science > Ageing, Longevity and disease. > Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell
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Highlights
• Fasting induces fatty acid oxidation (FAO) in intestinal stem and progenitor cells
• Aging reduces ISC numbers and function, correlating with decreased FAO
• PPAR/CPT1a-mediated FAO augments ISC function in aging and during regeneration
• PPARδ agonists boost and restore ISC and progenitor function in young and old age

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30163-2

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