Category: Nutrition and Fasting

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Study probes connection between diet quality and environmental sustainability | William & Mary

Study probes connection between diet quality and environmental sustainability | William & Mary

While a plant based diet may seem to have good environmental credentials, it isn’t necessarily better for the environment.

A plant based diet is also deficient and requires close attention and supplementation.

https://www.wm.edu/news/stories/2020/study-probes-connection-between-diet-quality-and-environmental-sustainability.php

Study probes connection between diet quality and environmental sustainability | William & Mary

Study probes connection between diet quality and environmental sustainability | William & Mary

While a plant based diet may seem to have good environmental credentials, it isn’t necessarily better for the environment.

A plant based diet is also deficient and requires close attention and supplementation.

https://www.wm.edu/news/stories/2020/study-probes-connection-between-diet-quality-and-environmental-sustainability.php

Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations | JACC: Journal of the American College of Cardiology

Dave Asprey seems to do a good job at explaining what this study means:

“Something truly epic happened today that is going to change what you eat for years to come. Truly epic. The Journal of the American College of cardiology published a groundbreaking paper today admitting something that you already knew if you had been on the Bulletproof Diet for the last 10 years. (Yes, I am feeling slightly vindicated after receiving so much resistance after writing The Bulletproof Diet, which eventually helped people lose about 1,000,000 pounds!)This new paper, which uses data from studying 135,000 people overtime, finds:-Saturated fat from meat and dairy do not cause an increase in cardiovascular disease, and reduce stroke risk.-Polyunsaturated fats increase risk of cardiovascular disease.-Different fats do different things-Cutting saturated fat does not reduce death rate-the 25% of people eating the highest saturated fat intake (about ∼14% of calories) had lower risk of stroke-Only 5% of fat should be polyunsaturated for lowest death. This is effectively a deathblow to vegan and plant-based practices, which make people sick over time because they contain almost all polyunsaturated fats. It’s one reason I got sicker when I was a vegan. (It takes 2 years to replace half your cell membrane fats when you change your diet.)”

Dietary Intakes of Minerals, Essential and Toxic Trace Elements for Adults from Eragrostis tef L.: A Nutritional Assessment

Dietary Intakes of Minerals, Essential and Toxic Trace Elements for Adults from Eragrostis tef L.: A Nutritional Assessment

“This study analysed the contents of thirty-six mineral and trace elements in teff (Eragrostis tef L.) grains. What is more, dietary intakes were calculated. Inductively coupled plasma mass spectrometry (ICP-MS) was used to assess mineral and trace element contents. Consequently, the appropriate Recommended Dietary Allowance (RDA) or adequate intake (AI), and provisional tolerable weekly intake (PTWI) or provisional tolerable monthly intake (PTMI) values for adults were determined according to the Food and Agriculture Organization/World Health Organization (FAO/WHO) and Institute of Medicine (IOM) regulations. Teff is a significant contributor to RDAs and AIs for females in the following order: Mn > Cu > Zn ≥ Mg > Fe ≥ P and Ca. For males, teff contributes in the order, Mn > Cu > Fe > Zn ≥ P ≥ Mg > and Ca. The concentration of arsenic (65.9 µg/kg) in brown teff originating in Bolivia exceeded the average acceptable value set by Reg. No. 1881 of 6–50 µg/kg in cereals consumed in the EU. The PTWIs or PTMIs for Al, Cd, Sn and Hg were all under 7%, which is below the limits of toxic element intake related to the body weight of 65 kg for adult females and 80 kg for males, set by the FAO/WHO. Teff grains can be recommended as a valuable and safe source of minerals and trace elements.”

Nutrients | Free Full-Text | Dietary Intakes of Minerals, Essential and Toxic Trace Elements for Adults from Eragrostis tef L.: A Nutritional Assessment | HTML
Matched Weight Loss Through Intermittent or Continuous Energy Restriction Does Not Lead To Compensatory Increases in Appetite and Eating Behavior

Matched Weight Loss Through Intermittent or Continuous Energy Restriction Does Not Lead To Compensatory Increases in Appetite and Eating Behavior

Controlled ≥5% WL via CER or IER did not differentially affect changes in body composition, reductions in hunger, and improvements in eating behavior traits. This suggests that neither CER nor IER lead to compensatory adaptations in appetite in women with overweight/obesity. This trial was registered at clinicaltrials.gov as NCT03447600.

https://academic.oup.com/jn/article-abstract/150/3/623/5673202?redirectedFrom=fulltext

High-Quality Plant-Based Protein Blends Compared to Whey Protein—A Double-Blind Randomized, Cross-Over, Clinical Trial

High-Quality Plant-Based Protein Blends Compared to Whey Protein—A Double-Blind Randomized, Cross-Over, Clinical Trial

A new study shows that plant based protein, selected for thier status as high quality, does not compare equally to animal based protein. The study found the plant based protein to be 40% less effective than the animal based Whey protein.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950667/

Metabolic Effects of Intermittent Fasting | Annual Review of Nutrition

Metabolic Effects of Intermittent Fasting | Annual Review of Nutrition

“Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.”

https://www.annualreviews.org/doi/abs/10.1146/annurev-nutr-071816-064634?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

An overlooked danger of ketogenic diets Making the case that ketone bodies induce vascular damage by the same mechanisms as glucose – ScienceDirect

An overlooked danger of ketogenic diets Making the case that ketone bodies induce vascular damage by the same mechanisms as glucose – ScienceDirect

Highlights
• Low-carbohydrate, ketogenic diets are associated with increased mortality

• Ketone bodies form adducts with proteins by the same mechanisms as glucose

• Ketone bodies and glucose may lead to vascular injury through common pathways

• Dietary ketosis as a means of avoiding glucose-induced vascular damage is futile

https://www.sciencedirect.com/science/article/abs/pii/S0899900720300460

Editors note: We have recently posted about the dangers of following fads and trends without full consideration. These eating strategies are meant for specific outcomes for specific people and for specific time windows.

Please ensure you do some research before you embark on any of these trending eating strategies.

Banana Lectin Offers Hope Against Deadly Flu

Banana Lectin Offers Hope Against Deadly Flu

“In a new paper published in the Proceedings of the National Academy of Sciences, researchers have shown that an engineered compound based on a banana lectin, a protein called H84T, has real potential for clinical use against influenza.”

http://sciencemission.com/site/index.php?page=news&type=view&id=microbiology-virology%2Fbanana-lectin-offers&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell

Highlights
• Fasting induces fatty acid oxidation (FAO) in intestinal stem and progenitor cells
• Aging reduces ISC numbers and function, correlating with decreased FAO
• PPAR/CPT1a-mediated FAO augments ISC function in aging and during regeneration
• PPARδ agonists boost and restore ISC and progenitor function in young and old age

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30163-2

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

“We confirm previous findings, showing age-related hypermethylation, and describe, for the first time, that this gain in methylation also occurs in human hepatocytes. Furthermore, we show that age-related hypermethylation is enhanced in livers of rat upon CR at two and 10 months, and that at two months a trend towards the reduction of rRNA expression occurs. Collectively, our results suggest that CR modulates age-related regulation of methylation at the rDNA locus, thus providing an epigenetic readout of the pro-longevity effects of CR.”

https://www.mdpi.com/2072-6643/12/2/277

The Healthy Grain BARLEYmax™ and Kebari Barley

The Healthy Grain BARLEYmax™ and Kebari Barley

Developed by CSIRO scientists, BARLEYmaxTM wholegrains represent the next evolution of superfoods, an enhanced wholegrain. The credentials of BARLEYmaxTM begin with it’s history. It was bred using traditional plant breeding processes, and is 100% GM free. The enhanced wholegrain discovered by Dr Morell and his team at the CSIRO contains two times the dietary fibre and four times the resistant starch of a regular grain.

The Healthy Grain BARLEYmax™ and Kebari Barley
Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in Caenorhabditis elegans – Novakovic – – FEBS Letters – Wiley Online Library

Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in Caenorhabditis elegans – Novakovic – – FEBS Letters – Wiley Online Library

“Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF‐1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and show that depletion of individual zipt genes results in a decreased lifespan”

https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13725

Fad or Future Podcast | Hosted by Joey Thurman

Fad or Future Podcast | Hosted by Joey Thurman

“I’ve been talking about the benefits of “stressed plants” a lot of late. And that’s because of xenohormesis. I believe that when we eat plants that have been stressed, our bodies pick up on those chemical cues and allows us to get the stress benefits. That is, our own hormesis benefits. This is one of the reasons why I believe organic foods are better for us. More here from my discussion with Joey Thurman”

David A Sinclair

Full link here:

https://www.fadorfuture.com/

3 Ways We May Be Able To Reverse Aging, From A Microbiologist

3 Ways We May Be Able To Reverse Aging, From A Microbiologist

“Organic foods aren’t held with gloves. They’re a little bit more stressed out. The more stressed out your food is the brighter colors they’ll have because they’re producing these colors as a defense,” Sinclair explains.

Those bright colors, he adds, are indicators that the food has produced “xenohormesis molecules,” which activate our sirtuins that give our bodies an extra boost for longevity.

https://www.mindbodygreen.com/articles/3-easy-hacks-for-longevity-from-an-aging-microbiologist

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation – ScienceDirect

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation – ScienceDirect

Highlights
• Tea-derived l-theanine inhibited AGE production in d-galactose-induced aging rats.

• l-Theanine increased FoxO1 expression and antioxidative enzymes in aged livers.

• l-Theanine could reduce oxygen free radicals and maintain the redox balance.

• l-Theanine supplementation could protect against age-related liver damage.

https://www.sciencedirect.com/science/article/pii/S0531556519306643

Role of High‐Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control | Journal of the American Heart Association

Role of High‐Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control | Journal of the American Heart Association

Emerging evidence (summarized in Table) indicates that HDL‐ and apoA‐I–targeted therapies are a potential option for conserving residual β‐cell function and improving insulin sensitivity in patients who are progressing toward, or have already developed, T1DM and T2DM. The recent failures of HDL‐raising agents in cardiovascular clinical outcome trials highlight the need to develop novel and innovative HDL‐targeted approaches to achieve these goals. Elucidating the mechanism(s) underlying the antidiabetic functions of HDLs and apoA‐I will also provide opportunities to identify and develop new HDL‐targeted therapies for diabetes mellitus. Achievement of these goals could be particularly advantageous for patients with T1DM for whom treatment options are currently limited to insulin replacement therapy, and for patients with T2DM that are refractory to currently available therapies.

Table 1.Role of HDL and apoA‐I in Glycemic Control, Insulin Sensitivity and β‐Cell Function
Topic Outcome Reference
Association of HDL‐C and apoA‐I levels with glycemic control
Subjects with T2DM Serum HDL‐C, apoA‐I, and HDL‐C/apoA‐I levels are inversely associated with insulin resistance by HOMA‐IR 9
Subjects with impaired glucose tolerance ApoA‐I level is an independent risk factor for glucose tolerance 10
HDL and apoA‐I in glucose disposal/insulin sensitivity
Primary human skeletal muscle cells ApoA‐I improves insulin‐dependent and ‐independent glucose uptake 27
C2C12 skeletal muscle cells ApoA‐I increases glucose uptake by phosphorylation of AMPK 35
High‐fat–fed C57BL/6 mice ApoA‐I improves insulin sensitivity by reducing systemic and hepatic inflammation 40
db/db mice Long‐term HDL infusion improves glucose tolerance by activating GSK‐3 and AMPK in skeletal muscle 37
Pregnant female Wistar rats ApoA‐I infusions increase insulin sensitivity, reduces systemic inflammation and protects against pregnancy‐induced insulin resistance 45
Subjects with T2DM A single rHDL infusion reduces plasma glucose levels by increasing insulin secretion and promoting glucose uptake in skeletal muscle 2
HDL and apoA‐I in β‐cell function
Min6 insulinoma cells HDLs isolated from normal human plasma, rHDLs, and apoA‐I increase Ins1 and Ins2 gene transcription and GSIS 58
Ins‐1E insulinoma cells ApoA‐I increases Pdx1 gene transcription and GSIS 57
βTC3 insulinoma cells Incubation with HDL protects βTC3 cells against LDL‐induced apoptosis 70
C57BL/6 mice ApoA‐I infusions increase insulin secretion and improve glucose tolerance 52
High‐fat–fed C57BL/6 mice Short‐term apoA‐I treatment increases GSIS and improves glucose clearance independent of insulin secretion 53
Mice with conditional deletion of ABCA1 and ABCG1 in β cells ApoA‐I infusions increase GSIS in islets isolated from mice with elevated islet cholesterol levels 54
Healthy subjects and Min6 cells CETP inhibition increases plasma HDL‐C, apoA‐I, and insulin levels in normal human subjects. Plasma from these subjects also increases GSIS in Min6 cells pretreated with oxidized LDLs 60
Isolated human islets HDL protects human islets against oxidized LDL‐induced apoptosis 71
Isolated human and mouse islets HDL protects human and mouse islets from interleukin‐1β– and glucose‐induced apoptosis 72
AMPK indicates adenosine monophosphate‐activated protein kinase; apoA‐I, apolipoprotein A‐I; CETP, cholesteryl ester transfer protein; GSIS, glucose‐stimulated insulin secretion; GSK, glycogen synthase kinase‐3; HDL, high‐density lipoprotein; HDL‐C, high‐density lipoprotein cholesterol; HOMA‐IR, Homeostatic model assessment of insulin resistance; LDL, low‐density lipoprotein; rHDL, reconstituted HDL.

https://www.ahajournals.org/doi/10.1161/JAHA.119.013531

Intermittent fasting: live ‘fast,’ live longer? | EurekAlert! Science News

Intermittent fasting: live ‘fast,’ live longer? | EurekAlert! Science News

“Mattson says studies have shown that this switch improves blood sugar regulation, increases resistance to stress and suppresses inflammation. Because most Americans eat three meals plus snacks each day, they do not experience the switch, or the suggested benefits.

In the article, Mattson notes that four studies in both animals and people found intermittent fasting also decreased blood pressure, blood lipid levels and resting heart rates.”

https://www.eurekalert.org/pub_releases/2019-12/jhm-ifl121819.php

Calorie restriction mimetics: Can you have your cake and eat it, too? – ScienceDirect

Calorie restriction mimetics: Can you have your cake and eat it, too? – ScienceDirect

Highlights
• We review the literature pertaining to calorie restriction mimetics (CRM).

• We discuss history, definitions, and applications of CRM.

• We discuss the concept of upstream and downstream targeting.

• We review the leading candidates for developing CRM.

• We suggest where the field is heading.

https://www.sciencedirect.com/science/article/pii/S1568163714001275

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 + T-cell memory development | Nature Cell Biology

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 + T-cell memory development | Nature Cell Biology

“Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual metabolic program raises the question of how Pck1 is upregulated in CD8+ Tmem cells. Here, we show that mitochondrial acetyl coenzyme A is diverted to the ketogenesis pathway, which indirectly regulates Pck1 expression. Mechanistically, ketogenesis-derived β-hydroxybutyrate is present in CD8+ Tmem cells; β-hydroxybutyrate epigenetically modifies Lys 9 of histone H3 (H3K9) of Foxo1 and Ppargc1a (which encodes PGC-1α) with β-hydroxybutyrylation, upregulating the expression of these genes.”

https://www.nature.com/articles/s41556-019-0440-0?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Effects of Intermittent Fasting on Health, Aging, and Disease | NEJM

Effects of Intermittent Fasting on Health, Aging, and Disease | NEJM

“Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.”

https://www.nejm.org/doi/full/10.1056/NEJMra1905136

Are Weight-Loss Supplements Safe?

Are Weight-Loss Supplements Safe?

Evidence-Based Eating Guide | NutritionFacts.org

Evidence-Based Eating Guide | NutritionFacts.org

The Evidence-Based Eating Guide: A Healthy Living Resource from Dr. Greger & NutritionFacts.org is a tool designed to help make the switch to a healthier lifestyle more simple. It’s an easy to understand guide with applicable information for eating healthier, including a breakdown of Dr. Greger’s Traffic Light Eating, tips for using Dr. Greger’s Daily Dozen checklist, sample menus, and more.

https://nutritionfacts.org/healthkit/

Weight for it: Time-restricted eating benefits those at risk for diabetes, heart disease | EurekAlert! Science News

Weight for it: Time-restricted eating benefits those at risk for diabetes, heart disease | EurekAlert! Science News

“The pilot study, published online in the December 5, 2019 edition of Cell Metabolism, found that when participants restricted their eating to 10 hours or less over a period of 12 weeks, they lost weight, reduced abdominal fat, lowered blood pressure and cholesterol and enjoyed more stable blood sugar and insulin levels.”

https://www.eurekalert.org/pub_releases/2019-12/uoc–wfi120519.php

Anti-inflammatory, analgesic and acute toxicity effects of fermented soybean | BMC Complementary and Alternative Medicine | Full Text

Anti-inflammatory, analgesic and acute toxicity effects of fermented soybean | BMC Complementary and Alternative Medicine | Full Text

NESTE is a nutritious food ingredient with potential anti-inflammatory and analgesic effects.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-019-2791-2

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies – ScienceDirect

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies – ScienceDirect

Highlights

From meta-analysis of RCTs in Alzheimer’s disease and Mild Cognitive Impairment, oral Medium Chain Triglycerides administration induced mild peripheral ketosis


From meta-analysis of RCTs in Alzheimer’s disease and Mild Cognitive Impairment, oral Medium Chain Triglycerides administration improved cognition on a combined scale of ADAS-Cog and MMSE.


Risk of bias of existing studies of RCTs in Alzheimer’s disease and Mild Cognitive Impairment necessitates future trials.

https://www.sciencedirect.com/science/article/pii/S156816371930131X

Consumption of chili pepper cuts down the risk of death from a heart or cerebral attack

Consumption of chili pepper cuts down the risk of death from a heart or cerebral attack

“Chili pepper is a common ingredient in Italians kitchens, and over the centuries, it has been praised for its supposed therapeutic virtues. Now, an Italian study shows that people who consume it on a regular basis have an all-cause mortality risk 23 percent lower than those who do not consume it.”

https://medicalxpress.com/news/2019-12-consumption-chili-pepper-death-heart.html

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect

Highlights

•Potassium (K+) channels are key regulators of cell excitability in several tissues.

•A dysregulation of K+ channels is associated with Alzheimer’s disease (AD).

•The role of K+ channels in AD is not completely elucidated.

•Understanding their functions will be helpful for clarifying AD pathogenesis.

•Modulating K+ channel expression should be useful for developing novel drugs.

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect
Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. – PubMed – NCBI

Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. – PubMed – NCBI

“These data indicate that dairy consumption leads to systemic effects, which may promote mitochondrial biogenesis in key target tissues such as muscle and adipose tissue both by direct activation of SIRT1 as well as by SIRT1-independent pathways.”

Notice the word dairy is used, not milk. see our previous post on milkand its mTor activation and AMPK suppression.

https://www.ncbi.nlm.nih.gov/pubmed/22185590

Understanding Niacin Side Effects

Understanding Niacin Side Effects

For those who plan to take high-dose niacin, the best advice appears to be to start a very low dose, e.g. 25 mg/d. This may cause a skin flush (30-60 minutes of warm skin) at first, but over several days the body gradually adapts to this dose and does not cause the skin flush. Then, slowly increase the dose over several weeks, taking the niacin in divided doses throughout the day, building up to 500 mg/d and over several months up to 1000 mg/d or higher, in consultation with your physician. You can start by breaking up 100 mg tablets into 4 pieces, taking one 25 mg piece per day at first, then after a few days increasing to 2 per day, and later up to 4 of the 25 mg pieces per day, one before each snack or meal. Once the body adapts to this dose, you may increase to one or more 100 mg tablets per day, and so on. [7] If at very high doses (1000 mg/day or higher) you note changes in your vision, especially in the central region (the fovea and macula) that you use to read fine print, you may want to lower the daily niacin dose by 50% or more to 1000 mg/day or below in divided doses. The vision problems may then disappear after a few weeks. This threshold effect has been reported by ophthalmologists who have studied the condition. [6] Of course, with any regimen of high-dose niacin, you should consult and work with your own physician.

Understanding Niacin Side Effects

Orthomolecular Medicine News Service

OMNS archive link http://orthomolecular.org/resources/omns/index.shtml

Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

” We reviewed and discussed underlying mechanisms of CR from an aspect of CR genes. It should be stressed that the isoform specificity of FoxO transcription factors for longevity becomes apparent under CR conditions but not AL conditions. Npy and FoxO1 both play pleiotropic roles in aging and related disorders, depending on the nutritional state. As briefly described in Section 1 and Section 2, the life-extending effects of CR and reduced IGF-1 signaling are also sexually dimorphic. Genes associated with regulation of the aging process should be investigated carefully in a context-dependent manner, i.e., abilities of physiological adaptation for individuals against environmental challenges, particularly food shortage. “

https://www.mdpi.com/2072-6643/11/12/3068/htm

Meat and masculinities. Can differences in masculinity predict meat consumption, intentions to reduce meat and attitudes towards vegetarians?

Meat and masculinities. Can differences in masculinity predict meat consumption, intentions to reduce meat and attitudes towards vegetarians?

Highlights

• New masculinity ideologies question popular beliefs like “real men eat meat”.

• The more men identify with new masculinity, the less they eat meat.

• This is mediated by men’s meat attachment, which is weaker for new masculine men.

• New masculinity also correlates positively with attitudes towards vegetarians.

• Studies about meat and vegetarianism should consider within-gender differences.

Frontiers | Physiological and Epigenetic Features of Yoyo Dieting and Weight Control | Genetics

Frontiers | Physiological and Epigenetic Features of Yoyo Dieting and Weight Control | Genetics

“Most individuals fail in maintaining their weight loss due to weight cycling, often referred to as Yoyo dieting. Weight regain often starts within the first year, and the pre-intervention weight is reached or even surpassed in the subsequent 2 to 5 years (Anderson et al., 2001; Weiss et al., 2007). Lean individuals that were voluntarily overfed with 50% additional calories for 3 days showed decreased pre-meal hunger and increased post-meal satiety (Cornier et al., 2004). In obese individuals that underwent weight loss, overfeeding did not diminish hunger or increase satiety. This absence of compensatory changes in hunger and satiety upon overfeeding likely contributes to an increased propensity for weight regain in obese individuals that undergo weight loss (Cornier et al., 2004). Overall, only 11% of the individuals with early-onset weight re-gain can achieve a subsequent body weight loss within that first year (Wing and Phelan, 2005).”

https://www.frontiersin.org/articles/10.3389/fgene.2019.01015/full?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size | SpringerLink

Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size | SpringerLink

“Caloric restriction was effective in decreasing body and fat weights, total cholesterol and LDL. These effects were totally or partially reversed after 30 days of refeeding (groups GRL). During liver perfusion, the high glucose output of the GRs was further enhanced by adrenaline (1 μM), but not by lactate infusion. In contrast, in groups G6L, G12 L, G6RL and G12RL glycogenolysis (basal and adrenaline-stimulated glucose output) was low and gluconeogenesis from lactate was significant. A twofold increase in liver content of PKA in group G6R suggests that liver sensitivity to glucagon and adrenaline was higher because of caloric restriction, resulting in enhanced glucose output.”

https://link.springer.com/article/10.1186/s12986-019-0413-0

Frontiers | Physiological and Epigenetic Features of Yoyo Dieting and Weight Control

Frontiers | Physiological and Epigenetic Features of Yoyo Dieting and Weight Control

“Obesity and being overweight have become a worldwide epidemic affecting more than 1.9 billion adults and 340 million children. Efforts to curb this global health burden by developing effective long-term non-surgical weight loss interventions continue to fail due to weight regain after weight loss. Weight cycling, often referred to as Yoyo dieting, is driven by physiological counter-regulatory mechanisms that aim at preserving energy, i.e. decreased energy expenditure, increased energy intake, and impaired brain-periphery communication. Models based on genetically determined set points explained some of the weight control mechanisms, but exact molecular underpinnings remained elusive. Today, gene–environment interactions begin to emerge as likely drivers for the obesogenic memory effect associated with weight cycling. Here, epigenetic mechanisms, including histone modifications and DNA methylation, appear as likely factors that underpin long-lasting deleterious adaptations or an imprinted obesogenic memory to prevent weight loss maintenance.”

Researchers discover brain circuit linked to food impulsivity: This creates the possibility scientists can someday develop therapeutics to address overeating — ScienceDaily

Researchers discover brain circuit linked to food impulsivity: This creates the possibility scientists can someday develop therapeutics to address overeating — ScienceDaily

https://www.sciencedaily.com/releases/2019/12/191211145630.htm

From Tea to treatment; Epigallocatechin Gallate and its potential involvement in minimizing the metabolic changes in Cancer

From Tea to treatment; Epigallocatechin Gallate and its potential involvement in minimizing the metabolic changes in Cancer

As the most abundant bioactive polyphenol in green tea, epigallocatechin gallate (EGCG) is a promising natural product that should be utilized in the discovery and development of potential drug leads. Due to its association with chemoprevention, EGCG may find a role in the development of therapeutics for prostate cancer. Natural products have long been employed as a scaffold for drug design, as their already noted bioactivity can help accelerate the development of novel treatments. Green tea and the EGCG contained within have become associated with chemoprevention, and both in vitro and in vivo studies have correlated EGCG to inhibiting cell growth and increasing the metabolic stress of cancer cells, possibly giving merit to its long utilized therapeutic use in traditional therapies. There is accumulating evidence to suggest that EGCG’s role as an inhibitor of the PI3K/Akt/mTOR signaling cascade, acting upon major axis points within cancer survival pathways. The purpose of this review is to examine the research conducted on tea along with EGCG in the areas of the treatment of and/or prevention of cancer. This review discusses Camellia sinensis, as well as the bioactive phytochemical compounds contained within. Clinical uses of tea are explored, and possible pathways for activity are discussed before examining the evidence for EGCG’s potential for acting on these processes. EGCG is identified as being a possible lead phytochemical for future drug design investigations.

https://www.sciencedirect.com/science/article/pii/S0271531719305007?dgcid=rss_sd_all&utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Milk exosomal miRNAs: potential drivers of AMPK-to-mTORC1 switching in β-cell de-differentiation of type 2 diabetes mellitus

Milk exosomal miRNAs: potential drivers of AMPK-to-mTORC1 switching in β-cell de-differentiation of type 2 diabetes mellitus

Milk exosomal miRNAs: potential drivers of AMPK-to-mTORC1 switching in β-cell de-differentiation of type 2 diabetes mellitus

“Persistent milk miRNA signaling adds a new perspective to the pathogenesis of T2DM and explains the protective role of breastfeeding but the diabetogenic effect of continued milk miRNA signaling by persistent consumption of pasteurized cow’s milk.”

http://link.springer.com/article/10.1186/s12986-019-0412-1?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Omega-3 Fatty Acids

Omega-3 Fatty Acids

“Omega-3s play important roles in the body as components of the phospholipids that form the structures of cell membranes [5]. DHA, in particular, is especially high in the retina, brain, and sperm [3,5,6]. In addition to their structural role in cell membranes, omega-3s (along with omega-6s) provide energy for the body and are used to form eicosanoids. Eicosanoids are signaling molecules that have similar chemical structures to the fatty acids from which they are derived; they have wide-ranging functions in the body’s cardiovascular, pulmonary, immune, and endocrine systems [1,2].

The eicosanoids made from omega-6s are generally more potent mediators of inflammation, vasoconstriction, and platelet aggregation than those made from omega-3s, although there are some exceptions [3,7]. Because both classes of fatty acids compete for the same desaturation enzymes, ALA is a competitive inhibitor of linoleic acid metabolism and vice versa [8]. Similarly, EPA and DHA can compete with arachidonic acid for the synthesis of eicosanoids. Thus, higher concentrations of EPA and DHA than arachidonic acid tip the eicosanoid balance toward less inflammatory activity [9].”

https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/

Impact of isocaloric exchanges of carbohydrate for fat on postprandial glucose, insulin, triglycerides, and free fatty acid responses

Impact of isocaloric exchanges of carbohydrate for fat on postprandial glucose, insulin, triglycerides, and free fatty acid responses

—a systematic review and meta-analysis | European Journal of Clinical Nutrition

https://www.nature.com/articles/s41430-019-0534-6

Eating in sync with biological clock could replace problematic diabetes treatment: An early-morning, carb-filled meal improves glycemic control among diabetics — ScienceDaily

Eating in sync with biological clock could replace problematic diabetes treatment: An early-morning, carb-filled meal improves glycemic control among diabetics — ScienceDaily

https://www.sciencedaily.com/releases/2019/12/191203114510.htm

Urban Environmental Health – Map My Environment

Urban Environmental Health – Map My Environment

“The VegeSafe program run by Macquarie University has been sampling backyard soil and household dust on behalf of homeowners across Sydney for several years.

They have now teamed up with researchers from seven countries across the globe to launch Map My Environment, an interactive tool allowing people to check levels of lead, arsenic and heavy metals in their suburb, based on more than 15,000 samples.” SMH Dec 1 2019

https://www.mapmyenvironment.com/

Krista Austin, Ph.D: Simplifying Sports Nutrition, and Are Female and Male Athletes More Similar Than We Think? – Endurance Planet

Krista Austin, Ph.D: Simplifying Sports Nutrition, and Are Female and Male Athletes More Similar Than We Think? – Endurance Planet

https://www.enduranceplanet.com/krista-austin-ph-d-simplifying-sports-nutrition-and-are-female-and-male-athletes-more-similar-than-we-think/

Watch “Late-night eating and melatonin may impair insulin response” on YouTube

Watch “Late-night eating and melatonin may impair insulin response” on YouTube

What is a stack and whats in one? – Opinion

What is a stack and whats in one? – Opinion

So you have a bunch of information on things that can help you live healthier and longer. What next?

Typically what a biohacker does is builds a stack. A stack is a collection of supplements that is aimed at a certain goal.

I’m going to give you some insight into my “pet rabbit” stack 😉 My rabbit is 104kgs and around 40 years old (Super Rabbit 😉 My rabbit is wanting to live healthier and longer as well as improve cognetive function and avoid cognitive decline. She wants to grow her hair and keep it a healthy colour and improve general health and fitness.

Firstly a dosing routine showing morning and evening dosing and which to take at what time of day for the desirable outcome.

Continue reading “What is a stack and whats in one? – Opinion”
An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

” In the past three decades, total fat and saturated fat intake as a percentage of total calories has continuously decreased in Western diets, while the intake of omega-6 fatty acid increased and the omega-3 fatty acid decreased, resulting in a large increase in the omega-6/omega-3 ratio from 1:1 during evolution to 20:1 today or even higher. This change in the composition of fatty acids parallels a significant increase in the prevalence of overweight and obesity. Experimental studies have suggested that omega-6 and omega-3 fatty acids elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, brain-gut-adipose tissue axis, and most importantly systemic inflammation. Prospective studies clearly show an increase in the risk of obesity as the level of omega-6 fatty acids and the omega-6/omega-3 ratio increase in red blood cell (RBC) membrane phospholipids, whereas high omega-3 RBC membrane phospholipids decrease the risk of obesity. Recent studies in humans show that in addition to absolute amounts of omega-6 and omega-3 fatty acid intake, the omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). A balanced omega-6/omega-3 ratio is important for health and in the prevention and management of obesity. ”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808858/

Save Aussie Supplements – call to action

Save Aussie Supplements – call to action

Opinion – While unsafe products should be regulated, an individual should be free to research and trial compounds that may or may not yet have shown clear evidence or clinical trials for efficacy.

Medial technology and knowledge is constantly changing and we cannot be held ransom to a slow moving TGA locking up beneficial compounds simply because they’ve not yet tested or studied them.

Click the link below if you agree to show the TGA that we need and want access to supplements that can improve our health.

https://www.saveaussiesupplements.com.au/

Watch “How to Personalize Your Nutrition Based On Genetics (Revised 3/19/15)” on YouTube

Watch “How to Personalize Your Nutrition Based On Genetics (Revised 3/19/15)” on YouTube

Limiting mealtimes may increase your motivation for exercise — ScienceDaily

Limiting mealtimes may increase your motivation for exercise — ScienceDaily

Limiting access to food in mice increases levels of the hormone, ghrelin, which may also increase motivation to exercise, according to a study published in the Journal of Endocrinology. The study suggests that a surge in levels of appetite-promoting hormone, ghrelin, after a period of fasting prompted mice to initiate voluntary exercise. These novel findings indicate that better diet control, for example limiting food intake to mealtimes or fasting intermittently, could help overweight people maintain a more effective exercise routine, lose weight and avoid debilitating complications such as diabetes and heart disease.

https://www.sciencedaily.com/releases/2019/10/191019154000.htm

Watch “Rhonda’s Ultimate Micronutrient Smoothie” on YouTube

Watch “Rhonda’s Ultimate Micronutrient Smoothie” on YouTube

Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily

Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily

Scientists at UC San Francisco and Harvard University have shown for the first time that cooking food fundamentally alters the microbiomes of both mice and humans, a finding with implications both for optimizing our microbial health and for understanding how cooking may have altered the evolution of the our microbiomes during human prehistory.

Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily
You don’t have to go cold turkey on red meat to see health benefits — ScienceDaily

You don’t have to go cold turkey on red meat to see health benefits — ScienceDaily

A new study has found that halving the amount red and processed (RPM) meat in the diet can have a significant impact on health, reducing the amount of LDL ‘bad’ cholesterol in the blood which cuts the risk of developing heart disease.Red and processed meat (RPM) include fresh pork, beef, lamb and veal and meats that have been smoked, cured or preserved (other than freezing) in some way. These meats are typically high in saturated fatty acids which cause an increase in LDL cholesterol. This is the “bad” cholesterol that collects in the walls of blood vessels, where it can cause blockages and raise the chance of a heart attack.Increasing awareness of the risks associated with eating red and processed meat has led to a growing number of people adopting vegetarian and vegan diets, which cut out meat completely. Researchers at the University of Nottingham wanted to find out if reducing the amount of red meat eaten, rather than cutting it out completely, would have a positive effect on the health of the subjects taking part.

You don’t have to go cold turkey on red meat to see health benefits — ScienceDaily
High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily

High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily

Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content.

High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily
No need to cut down red and processed meat for health reasons, controversial findings suggest — ScienceDaily

No need to cut down red and processed meat for health reasons, controversial findings suggest — ScienceDaily

Most people can continue to eat red and processed meat as they do now. A major study led by researchers at McMaster and Dalhousie universities has found cutting back has little impact on health.A panel of international scientists systematically reviewed the evidence and have recommended that most adults should continue to eat their current levels of red and processed meat.The researchers performed four systematic reviews focused on randomized controlled trials and observational studies looking at the impact of red meat and processed meat consumption on cardiometabolic and cancer outcomes.In one review of 12 trials with 54,000 people, the researchers did not find statistically significant or an important association between meat consumption and the risk of heart disease, diabetes or cancer.

No need to cut down red and processed meat for health reasons, controversial findings suggest — ScienceDaily
Shipment tracking for ‘fat parcels’ in the body: Researchers show that highly sensitive method can ‘track’ lipid metabolism — ScienceDaily

Shipment tracking for ‘fat parcels’ in the body: Researchers show that highly sensitive method can ‘track’ lipid metabolism — ScienceDaily

Without fat, nothing works in the body: These substances serve as energy suppliers and important building blocks — including for the envelopes of living cells. Numerous diseases are related to disorders in the fat metabolism, such as obesity or cancer. Researchers are now demonstrating how the fat metabolism can be monitored down to the individual liver cell of a mouse with the greatest sensitivity.

Shipment tracking for ‘fat parcels’ in the body: Researchers show that highly sensitive method can ‘track’ lipid metabolism — ScienceDaily
Watch “Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health” on YouTube

Watch “Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health” on YouTube

Watch “Time-Restricted Eating May Reverse Diabetes & Obesity” on YouTube

Watch “Time-Restricted Eating May Reverse Diabetes & Obesity” on YouTube

Simplified Methylation Treatment Plan for Chronic Fatigue Syndrome (CFS) by Rich Van Konynenburg, Ph.D. – Health Rising

Simplified Methylation Treatment Plan for Chronic Fatigue Syndrome (CFS) by Rich Van Konynenburg, Ph.D. – Health Rising

https://www.healthrising.org/treating-chronic-fatigue-syndrome/treatment-protocols/methylation-treatment-plan-chronic-fatigue-syndrome-me-cfs-konynenburg-ph-d-ii/

Although talking about chronic fatigue syndrome, it’s important to know about methylation especially if you’re supplementing with b group vitamins

Despite growing burden of diet-related disease, medical education does not equip students to provide high quality nutritional care to patients: Researchers call for improved nutrition education to be integrated into the medical curriculum — ScienceDaily

Despite growing burden of diet-related disease, medical education does not equip students to provide high quality nutritional care to patients: Researchers call for improved nutrition education to be integrated into the medical curriculum — ScienceDaily

This is why you don’t ask your doctor about nutrition and, why they very likely won’t know about anything on this blog.

https://www.sciencedaily.com/releases/2019/09/190918184454.htm

Innovative model created for NASA to predict vitamin levels in spaceflight food: Mathematical tool from UMass Amherst researchers will ensure proper nutrition for astronauts on long missions — ScienceDaily

Innovative model created for NASA to predict vitamin levels in spaceflight food: Mathematical tool from UMass Amherst researchers will ensure proper nutrition for astronauts on long missions — ScienceDaily

https://www.sciencedaily.com/releases/2019/09/190912130647.htm