The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions – Metabolism – Clinical and Experimental

Health Hacker Australia > The Science > Ageing, Longevity and disease. > The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions – Metabolism – Clinical and Experimental
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Highlights
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The mitochondrial NAD+ transporter Slc25a51 is a fasting-induced gene.
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Liver Slc25a51 is regulated by circadian rhythm and is a target of BMAL1.
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Reduced Slc25a51 expression suppressed mitochondrial NAD+ levels and SIRT3 activity in hepatocytes and the liver.
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Reduced Slc25a51 expression suppressed oxygen consumption rate in hepatocytes.
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Reduced hepatic Slc25a51 expression caused fatty liver and hypertriglyceridemia in mice

https://www.metabolismjournal.com/article/S0026-0495(22)00153-6/fulltext

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