Highlights
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Hedgehog signaling in murine fibroblasts induces new hair growth and hair multiplication
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Hedgehog activation increases fibroblast heterogeneity and drives new cell states
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TGF-? pathway downstream of dermal Hedgehog mediates hair growth hyper-activation
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SCUBE3 is a new mesenchymal niche factor that activates hair growth
GFC with FGF5s and NMN with microneedling is an effective and safe treatment of androgenetic alopecia. Future studies with more thorough investigations in controlled clinical settings are warranted.
Androgenetic alopecia (AGA) is the most common cause of hair loss. Several FDA approved medications are available
but offer limited results. Studies have shown that the endocannabinoid system (ECS) is a key player in hair follicle
cell growth. The ECS can
nabinoid type one (CB1) receptors are well expressed in the hair follicle cells. Cannabidiol
CBD is a negative allosteric modulator of the CB1 receptor and has been shown to result in hair shaft elongation. In
addition, the hair follicle cycle phases are c
ontrolled by the ECS vanilloid receptor
–
1 (TRPV1). CBD has also been
shown to increase Wnt signaling pathways that are involved in the differentiation of dermal progenitor cells into new
hair follicles and maintaining the anagen phase of the hair cycle. Th
e effects of CBD on hair growth are dose
dependent and higher doses may result in premature entry into the catagen phase via a receptor known as vanilloid
receptor
–
4 (TRPV4). Topical application of CBD reaches hair follicles where it is a CB1 negative modu
lator, and
TRPV1, and TRPV4 agonist. A study was done of 35 subjects with AGA using a once daily topical hemp oil
formulation, averaging about 3
–
4 mg per day of CBD and minimal amounts of other cannabinoids for six months. A
hair count of the greatest area
of alopecia was carried out before treatment and again after six months. The results
revealed that men did slightly better than women, and the vertex area did better than the temporal areas. On
average there was statistically significant 93.5% increase in
hair after 6 months. All subjects had some regrowth.
There were no reported adverse effects. Since the CBD works through novel mechanisms different from finasteride
and minoxidil it can be used in conjunction with these current drugs and would be expected
to have synergistic
effects.
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/78/47
Background: Vernonia anthelmintica (L.) willd is a traditional urgur herb in China for a long history. Its alcohol extract (AVE) has been proved to promote hair follicle growth in C57BL/6 mice. We conducted this study to investigate the hair-growth effects of AVE in stressed mice and its possible mechanism of action
Results: Our results showed that AVE counteract murine hair follicle growth inhibition caused by chronic restraint stress via inducing the conversion of telogen to anagen and inhibiting catagen premature, increasing bulb keratinocytes and bulge stem cells proliferation, promoting melanogenesis, and reducing the numbers of substance P and calcitonin gene-related peptide nerve fibers. Furthermore, AVE also counteracted murine hair follicle growth inhibition caused by substance P in organ culture. Conclusion: These results suggest that AVE counteract stress-induced hair follicle growth inhibition in C57BL/6 mice in vivo and in vitro, and may be an effective new candidate for treatment of stress-induced hair loss.
https://bmccomplementalternmed.biomedcentral.com/track/pdf/10.1186/s12906-019-2744-9