chronic Archives - Health Hacker Australia

Distinct DNA methylation targets by aging and chronic inflammation

Posted on 13/12/201913/12/2019 by Nathan

a pilot study using gastric mucosa infected withÂ Helicobacter pylori

” Aberrant DNA methylation is induced by aging and chronic inflammation in normal tissues. The induction by inflammation is widely recognized as acceleration of age-related methylation. However, few studies addressed target genomic regions and the responsible factors in a genome-wide manner. Here, we analyzed methylation targets by aging and inflammation, taking advantage of the potent methylation induction in human gastric mucosa byÂ Helicobacter pyloriÂ infection-triggered inflammation. “

https://link.springer.com/article/10.1186/s13148-019-0789-8?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Chronic inflammation in the etiology of disease across the life span. – PubMed – NCBI

Posted on 08/12/2019 by Nathan

“Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.”

https://www.ncbi.nlm.nih.gov/pubmed/31806905?dopt=Abstract