Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment – Quarles – – Aging Cell – Wiley Online Library
“In this report, we demonstrate that the rapamycinâ€dependent improvement of diastolic function is highly persistent, while decreases in both cardiac hypertrophy and passive stiffness are substantially persistent 8 weeks after cessation of an 8â€week treatment of rapamycin in both male and female 22†to 24â€monthâ€old C57BL/6NIA mice.”