IJMS | Free Full-Text | BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians
“B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways.”