Highlights
• The immune system is responsive to the physiological stress imposed by the exercise workload.

• Technological advances now allow a systems biology approach to exercise immunology.

• The immune response to exercise is influenced by small-molecule metabolites and proteins.

• Immunometabolism has provided new insights into how metabolites influence immune function.

• Exercise has a modulating effect on gut microbial populations.

https://www.sciencedirect.com/science/article/pii/S2095254619301528