Category: Gut and Microbiome

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Psychobiotics: The Next-Generation Probiotics for the Brain – PubMed

Psychobiotics: The Next-Generation Probiotics for the Brain – PubMed

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Psychobiotics are a special class of probiotics, which deliver mental health benefits to individuals. They differ from conventional probiotics in their ability to produce or stimulate the production of neurotransmitters, short-chain fatty acids, enteroendocrine hormones and anti-inflammatory cytokines. Owing to this potential, psychobiotics have a broad spectrum of applications ranging from mood and stress alleviation to being an adjuvant in therapeutic treatment for various neurodevelopment and neurodegenerative disorders. The common psychobiotic bacteria belong to the family Lactobacilli, Streptococci, Bifidobacteria, Escherichia and Enterococci. The two-way crosstalk between the brain and the gastrointestinal system is influenced by these bacteria. The neurons present in the enteric nervous system interact directly with the neurochemicals produced by microbiota of the gut, thereby influencing the signaling to central nervous system. The present review highlights the scope and advancements made in the field, enlisting numerous commercial psychobiotic products that have flooded the market. In the latter part we discuss the potential concerns with respect to psychobiotics, such as the effects due to withdrawal, compatibility with immunocompromised patients, and the relatively unregulated probiotic market.

https://pubmed.ncbi.nlm.nih.gov/33394083/

Therapeutic potential of Short Chain Fatty acid production by gut microbiota in Neurodegenerative disorders

Therapeutic potential of Short Chain Fatty acid production by gut microbiota in Neurodegenerative disorders

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The current systematic review and meta-analysis indicate that dietary fermentation of non-digestible fibers leads to the production of SCFA (Short Chain Fatty Acids) by gut microbiota. Moreover, they directly act on the central nervous system and inhibit the progression of different neurodegenerative diseases like Parkinson Disease (PD), Alzheimer Disease (AD) and Multiple Sclerosis (MS). SCFAs act by activating cellular antioxidants and inhibiting inflammation. The properties of SCFAs depend on the G-protein coupled receptors (GPCR), histone deacetylases (HDAC) & peroxisome proliferator-activated receptor gamma (PPAR?) and regulatory T cells (Tregs) activation.

Therapeutic potential of Short Chain Fatty acid production by gut microbiota in Neurodegenerative disorders https://link.researcher-app.com/Kr8N – via Researcher (@ResearcherApp)

The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD

The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD

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The latest research cumulates staggering information about the correlation between the microbiota-gut-brain axis and neurodevelopmental disorders. This review aims to shed light on the potential influence of the microbiome on the development of the most prevalent neurodevelopmental disease, attention-deficit-hyperactive disorder (ADHD). As the etiology and pathophysiology of ADHD are still unclear, finding viable biomarkers and effective treatment still represent a challenge. Therefore, we focused on factors that have been associated with a higher risk of developing ADHD, while simultaneously influencing the microbial composition. We reviewed the effect of a differing microbial makeup on neurotransmitter concentrations important in the pathophysiology of ADHD. Additionally, we deduced factors that correlate with a high prevalence of ADHD, while simultaneously affecting the gut microbiome, such as emergency c-sections, and premature birth as the former leads to a decrease of the gut microbial diversity and the latter causes neuroprotective Lactobacillus levels to be reduced. Also, we assessed nutritional influences, such as breastfeeding, ingestion of short-chain fatty acids (SCFAs) and polyunsaturated fatty acids (PUFAs) on the host?s microbiome and development of ADHD. Finally, we discussed the potential significance of Bifidobacterium as a biomarker for ADHD, the importance of preventing premature birth as prophylaxis and nutrition as a prospective therapeutic measurement against ADHD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893446/

Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics

Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics

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DMNS has a good effect in treating ADHD, and it may exert this effect by regulating the gut microbiota and affecting metabolites in the peripheral circulation.

Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics https://link.researcher-app.com/kZmz – via Researcher (@ResearcherApp)

A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases | PNAS

A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases | PNAS

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The microbiome, an important regulator of metabolic and immune-related phenotypes, has been shown to be associated with or participate in the development of a variety of chronic diseases. Viruses of bacteria (i.e., “phages”) are ubiquitous and mysterious, and several studies have shown that phages exert great control over the behavior—and misbehavior—of their host bacteria.

https://www.pnas.org/content/118/23/e2023202118.long

Health and disease markers correlate with gut microbiome composition across thousands of people | Nature Communications

Health and disease markers correlate with gut microbiome composition across thousands of people | Nature Communications

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“We identify major axes of taxonomic variance in the gut and a putative diversity maximum along the Firmicutes-to-Bacteroidetes axis. Our analyses reveal both known and unknown associations between microbiome composition and host clinical markers and lifestyle factors, including host-microbe associations that are composition-specific. These results suggest potential opportunities for targeted interventions that alter the composition of the microbiome to improve host health.”

https://www.nature.com/articles/s41467-020-18871-1

The Healthy Grain BARLEYmaxâ„¢ and Kebari Barley

The Healthy Grain BARLEYmaxâ„¢ and Kebari Barley

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Developed by CSIRO scientists, BARLEYmaxTM wholegrains represent the next evolution of superfoods, an enhanced wholegrain. The credentials of BARLEYmaxTM begin with it’s history. It was bred using traditional plant breeding processes, and is 100% GM free. The enhanced wholegrain discovered by Dr Morell and his team at the CSIRO contains two times the dietary fibre and four times the resistant starch of a regular grain.

The Healthy Grain BARLEYmaxâ„¢ and Kebari Barley
Exercise immunology: Future directions – ScienceDirect

Exercise immunology: Future directions – ScienceDirect

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Highlights
• The immune system is responsive to the physiological stress imposed by the exercise workload.

• Technological advances now allow a systems biology approach to exercise immunology.

• The immune response to exercise is influenced by small-molecule metabolites and proteins.

• Immunometabolism has provided new insights into how metabolites influence immune function.

• Exercise has a modulating effect on gut microbial populations.

https://www.sciencedirect.com/science/article/pii/S2095254619301528

The Vagus Nerve is Key to Well-Being | Elemental

The Vagus Nerve is Key to Well-Being | Elemental

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“The vagus nerve, also called the “10th cranial nerve,” is the longest, largest, and most complex of the cranial nerves, and in some ways it’s also the least understood. Experts have linked its activity to symptom changes in people with migraine headaches, inflammatory bowel disease, depression, epilepsy, arthritis, and many other common ailments. The more science learns about the vagus nerve, the more it seems like a better understanding of its function could unlock new doors to treating all manner of human suffering.”

https://elemental.medium.com/science-confirms-that-the-vagus-nerve-is-key-to-well-being-c23fab90e211

What is The Gut-Brain Axis? An Exploration of The Communication Pathways Between The Brain, The Gut, And The Microbiota

What is The Gut-Brain Axis? An Exploration of The Communication Pathways Between The Brain, The Gut, And The Microbiota

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“Key Learning Objectives:

– Understand the importance of a gut-brain communication system

– Learn about signaling pathways in the gut-brain axisLearn how the gut microbiota influences brain function

– Discover how the gut microbiota can be targeted to influence brain function

WHAT IS THE GUT-BRAIN AXIS?

The gut, its microbes, and the brain are connected by a complex communication and regulation system called the gut-brain axis. The gut-brain axis (also known as brain-gut axis, microbiota-gut-brain axis, gut-brain connection) is a bidirectional signaling network made up of neurons, hormones, immune cells, and microbial molecules.[1,2] It is part of a larger system that informs the brain of the internal state and health of our body. This sense is called interoception and it’s crucial for the maintenance of physiological balance in our body, a state known as homeostasis.[3] “

What is The Gut-Brain Axis? An Exploration of The Communication Pathways Between The Brain, The Gut, And The Microbiota
Discordant transmission of bacteria and viruses from mothers to babies at birth | SpringerLink

Discordant transmission of bacteria and viruses from mothers to babies at birth | SpringerLink

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“The maternal gut microbiome significantly influences infant gut microbiome acquisition. Vertical transmission of the bacterial microbiome is substantially higher compared to vertical transmission of the virome. However, the degree of similarity between the maternal and infant gut bacterial microbiome and virome did not vary by delivery route. The greater similarity of the bacterial microbiome and virome between twin pairs than unrelated twins may reflect a shared environmental exposure. Thus, differences of the inter-generation transmissibility at birth between the major kingdoms of microbes indicate that the foundation of these microbial communities are shaped by different rules.”

https://link.springer.com/article/10.1186/s40168-019-0766-7

Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities

Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities

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“Probiotic bacteria are increasingly gaining importance in human nutrition owing to their multifaceted health beneficial effects. Studies have also shown that probiotic supplementation is useful in mitigating age-associated oxi-inflammatory stress, immunosenescence, and gut dysbiosis thereby promoting health and longevity. However, our current understanding of the process of aging suggests a strong interrelationship between the accumulation of senescent cells and the development of aging phenotype, including the predisposition to age-related disorders. The present review studies the documented pro-longevity effects of probiotics and highlights how these beneficial attributes of probiotics could be related to the mitigation of cellular senescence. ”

https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1697148?af=R&utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Microbiome: Untapped source of novel antimicrobials

Microbiome: Untapped source of novel antimicrobials

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Just as Gold Rush prospectors once mined the Northern California hills for the shiny precious metal, “bioprospectors” are searching for a new prize: potential antimicrobial molecules—and they are hunting them down in the human microbiome.

https://medicalxpress.com/news/2019-10-microbiome-untapped-source-antimicrobials.html

Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily

Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily

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Scientists at UC San Francisco and Harvard University have shown for the first time that cooking food fundamentally alters the microbiomes of both mice and humans, a finding with implications both for optimizing our microbial health and for understanding how cooking may have altered the evolution of the our microbiomes during human prehistory.

Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily
The Gut Microbiome Affects Muscle Strength in Older Adults | | LEAF

The Gut Microbiome Affects Muscle Strength in Older Adults | | LEAF

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A role for the gut microbiome on the health and functioning of many tissues, including the brain, liver, kidney, and adiposity, has been widely reported in the literature. Interestingly, 2019 might be the year that the role of the gut microbiome on skeletal muscle (i.e. the gut-muscle axis) comes into greater focus. The influence of the gut microbiome on muscle strength In April, Nay et al. reported that endurance exercise capacity was reduced in mice that do not contain a microbiome (germ-free mice, GFM) when compared with conventionally raised, microbiome-containing mice. This finding suggests that there are microbes in the gut that positively influence aerobic exercise performance.

The Gut Microbiome Affects Muscle Strength in Older Adults | | LEAF
The Life Extension Blog: Let’s Talk about Gut Health and Probiotics with Marisa Moore, RDN

The Life Extension Blog: Let’s Talk about Gut Health and Probiotics with Marisa Moore, RDN

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Growing research suggests that gut health goes well beyond good digestion.2 It may have an impact on the immune system and mood.3-5 Research on gut bacteria continues to grow and may be a key factor in understanding and maintaining gut health.

The Life Extension Blog: Let’s Talk about Gut Health and Probiotics with Marisa Moore, RDN
Biomedical Sciences Researchers Isolate Gut Bacteria That Can Prevent And Cure Rotavirus Infection – Georgia State University News – Faculty, Institute for Biomedical Sciences, Press Releases, Research, University Research

Biomedical Sciences Researchers Isolate Gut Bacteria That Can Prevent And Cure Rotavirus Infection – Georgia State University News – Faculty, Institute for Biomedical Sciences, Press Releases, Research, University Research

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https://news.gsu.edu/2019/10/10/biomedical-sciences-researchers-isolate-gut-bacteria-that-can-prevent-and-cure-rotavirus-infection/

Intestinal gases: influence on gut disorders and the role of dietary manipulations | Nature Reviews Gastroenterology & Hepatology

Intestinal gases: influence on gut disorders and the role of dietary manipulations | Nature Reviews Gastroenterology & Hepatology

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Soon, upon your visit to the GP for a checkup, you’ll not only be asked to cough but, you may be asked to fart for your doctor as well.

https://www.nature.com/articles/s41575-019-0193-z

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition: Cell Host & Microbe

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition: Cell Host & Microbe

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https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(19)30348-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312819303488%3Fshowall%3Dtrue

In a first, scientists map the genetic diversity of microbes residing in the human gut and mouth

In a first, scientists map the genetic diversity of microbes residing in the human gut and mouth

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“The findings thus far: There may be more genes in the collective human microbiome than stars in the observable universe, and at least half of these genes appear to be unique to each individual—a diversity far exceeding the researchers’ expectations.”

https://medicalxpress.com/news/2019-08-scientists-genetic-diversity-microbes-residing.html

Episode 108 – Brain vs Gut — ATP Science USA

Episode 108 – Brain vs Gut — ATP Science USA

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In today podcast Jeff, Matt and Steve delve straight back into gut health and its relationship to the brain, your immune systems and hormone production specifically Serotonin. Steve breaks out some new research showing the impact of serotonin in the gut and its affects on ADHD and Parkinson’s. While Matt shares some information on polyphenols and the results of his new gut product prototype. The boys answer some FAQ’s on Hirsutism, and PCOS, Banana rolls which are the rolls under the bum of a bikini competitor and her battle with cellulite, Glucose disposal agents and a sufferer from a chronic allergic reaction As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle

Source: Episode 108 – Brain vs Gut — ATP Science USA

Common food additive found to effect gut microbiota – The University of Sydney

Common food additive found to effect gut microbiota – The University of Sydney

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Experts call for better regulation of a common additive in foods and medicine, as research reveals it can impact the gut microbiota and contribute to inflammation in the colon, which could trigger diseases such as inflammatory bowel diseases and colorectal cancer.

Source: Common food additive found to effect gut microbiota – The University of Sydney

Healthy fat hidden in dirt may fend off anxiety disorders – Neuroscience News

Healthy fat hidden in dirt may fend off anxiety disorders – Neuroscience News

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10(Z)-hexadecenoic acid, a fatty acid found in the soil based bacterium Mycobacterium vaccae, interacts with immune cells to inhibit pathways that drive inflammation and increases resilience to stress. Researchers say the findings could bring us one step closer to developing a microbe-based “stress vaccine”.

Source: Healthy fat hidden in dirt may fend off anxiety disorders – Neuroscience News

Episode 131 – Microbiome – Firmicutes Make you Fat! — ATP Science USA

Episode 131 – Microbiome – Firmicutes Make you Fat! — ATP Science USA

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In today’s podcast Steve, Matt and Jeff discuss the microbiome and the role the gut plays in relation to the hormones oestrogen and testosterone and how the oddly named organism firmacutes that live in your gut, do anything but make you Firm and Cute. They also answer FAQs on Detoxing after taking antibiotics, Fat loss plateau and nodular acne. As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposed only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle.

Source: Episode 131 – Microbiome – Firmicutes Make you Fat! — ATP Science USA

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome | Molecular Psychiatry

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome | Molecular Psychiatry

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Article

Source: Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome | Molecular Psychiatry

The Integrative Human Microbiome Project | Nature

The Integrative Human Microbiome Project | Nature

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Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.

Source: The Integrative Human Microbiome Project | Nature

Research confirms gut-brain connection in autism. The discovery confirms a gut-brain nervous system link in autism, opening a new direction in the search for potential treatments that could ease behavioural issues associated with autism by targeting the gut. : science

Research confirms gut-brain connection in autism. The discovery confirms a gut-brain nervous system link in autism, opening a new direction in the search for potential treatments that could ease behavioural issues associated with autism by targeting the gut. : science

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Research confirms gut-brain connection in autism. The discovery confirms a gut-brain nervous system link in autism, opening a new direction in the search for potential treatments that could ease behavioural issues associated with autism by targeting the gut.
byu/Wagamaga inscience