The current systematic review and meta-analysis indicate that dietary fermentation of non-digestible fibers leads to the production of SCFA (Short Chain Fatty Acids) by gut microbiota. Moreover, they directly act on the central nervous system and inhibit the progression of different neurodegenerative diseases like Parkinson Disease (PD), Alzheimer Disease (AD) and Multiple Sclerosis (MS). SCFAs act by activating cellular antioxidants and inhibiting inflammation. The properties of SCFAs depend on the G-protein coupled receptors (GPCR), histone deacetylases (HDAC) & peroxisome proliferator-activated receptor gamma (PPAR?) and regulatory T cells (Tregs) activation.

Therapeutic potential of Short Chain Fatty acid production by gut microbiota in Neurodegenerative disorders https://link.researcher-app.com/Kr8N – via Researcher (@ResearcherApp)