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NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis – ScienceDirect

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis – ScienceDirect

Posted on by Nathan

Highlights
• NAD+ plays an important protective role in some age-related degenerative disease states.

• NAD+ can improve mitochondrial function and maintain sufficient levels of ATP.

• NAD+ can influences DNA repair, and immune and longevity processes.

• Raising NAD+ levels can balance energy needs with supply and protect against oxidative damage and inflammation.

• Further clinical trials are necessary to validate NAD+ therapy in ageing and disease.

https://www.sciencedirect.com/science/article/pii/S0531556519307582

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect

Posted on by Nathan

Highlights

•Potassium (K+) channels are key regulators of cell excitability in several tissues.

•A dysregulation of K+ channels is associated with Alzheimer’s disease (AD).

•The role of K+ channels in AD is not completely elucidated.

•Understanding their functions will be helpful for clarifying AD pathogenesis.

•Modulating K+ channel expression should be useful for developing novel drugs.

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect