https://www.leafscience.org/nad-and-aging/

http://www.nutritionaloutlook.com/science/clinical-study-affirms-niagen-nicotinamide-riboside-ingredients-long-term-safety-optimal-dosing

This company and its subsidiaries are the ones to watch in regards to a tested and effective treatment for aging.

Dr. David Sinclair runs or had a hand in setting them up and they will be the ones releasing these treatments.

https://lifebiosciences.com/companies/

https://www.sciencenews.org/article/mapping-how-immortal-hydra-regrows-cells-may-demystify-regeneration

https://www.scopus.com/record/display.uri?eid=2-s2.0-85066236523&origin=inward&txGid=cc6a43221bf78f59d21e5f315df05c45

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115505/?fbclid=IwAR0YMX2dWwx1mz_UtA847j63vlqBn9EZtDKEKvr6srCkd_nwgMzNSJK8phQ

https://www.ncbi.nlm.nih.gov/pubmed/31357227/

https://neurosciencenews.com/cell-aging-14574/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487780/

Yup, plants use NAD+ just like we do.

https://www.nature.com/articles/s41514-017-0016-9

https://www.fightaging.org/archives/2019/06/cellular-senescence-as-a-program-of-the-innate-immune-system/

Activation of Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, is an unexplored therapeutic approach for treatment of inflammatory diseases. We randomized 40 patients with moderate-to-severe psoriasis (4:1) to three escalating doses of SRT2104, a selective activator of SIRT1, or placebo. Across all SRT2104 groups, 35% of patients (p<0.0001) achieved good to excellent histological improvement based on skin biopsies taken at baseline and day 84 but was not consistently in agreement with PASI. Improvement in histology was associated with modulation of IL-17 and TNF-α signaling pathways and keratinocyte differentiation target genes. 27 subjects (69%) across all treatment groups, including placebo, experienced at least one treatment emergent adverse event. The majority of AEs were either mild or moderate. Most common were headache (8%), dizziness (8%), upper respiratory tract infection (8%), and psoriatic arthropathy (8%). Average drug exposure increased in a dose-dependent manner for escalating doses of SRT2104 and had high intra-subject variability in exposure (AUC %CV: 51–89%). Given the interesting signals of clinical activity, impact on gene expression and the generally favorable safety profile seen in this study, further investigation of SIRT1 activators for the treatment of psoriasis is warranted. Trial Registration Clinicaltrials.gov NCT01154101

Source: A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

A flavonoid called fisetin once again has been called out for its potential antiaging and neuroprotective properties.

Source: What Are the Benefits of Fisetin?

Source: Fisetin May be a Low-Hanging Fruit for Aging | | LEAF

Source: Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice

Brain Res. 2016 Jul 15;1643:1-9. doi: 10.1016/j.brainres.2016.04.060. Epub 2016 Apr 26. Research Support, Non-U.S. Gov’t

Source: Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. – PubMed – NCBI

Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016/j.cmet.2011.08.014. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov’t

Source: Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. – PubMed – NCBI

Rejuvenation Res. 2014 Feb;17(1):62-9. doi: 10.1089/rej.2014.1546. Review

Source: Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. – PubMed – NCBI

Nicotinamide mononucleotide | C11H15N2O8P | CID 14180 – structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Source: Nicotinamide mononucleotide | C11H15N2O8P – PubChem

If you spend enough time reading up on B3 vitamins, you’ll inevitably come across a […]

Source: What the Science Says About B3 Vitamins and Methylation – AboutNAD

A flavonoid called fisetin once again has been called out for its potential antiaging and neuroprotective properties.

Source: What Are the Benefits of Fisetin?

(2018). NAD+ Biosynthesis and Signaling in Plants. Critical Reviews in Plant Sciences: Vol. 37, No. 4, pp. 259-307.

Source: NAD+ Biosynthesis and Signaling in Plants: Critical Reviews in Plant Sciences: Vol 37, No 4