Category: Other health links
Nitric oxide signaling in health and disease
The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is complex, and novel insights into the control of NO biosynthesis and mechanisms of signal transduction are continuously emerging. NO is a key regulator of cardiovascular function, metabolism, neurotransmission, immunity, and more, and aberrant NO signaling is a central feature of many major disorders including cardiovascular disease, diabetes, and cancer. Here, we discuss the basics of NO biology emphasizing recent advances in the field including novel means of increasing NO bioactivity with therapeutic and nutritional implications.
Nitric oxide signaling in health and disease https://link.researcher-app.com/aSxM – via Researcher (@ResearcherApp)
As US obesity epidemic grows, new study shows | EurekAlert!
The article, published in the Journal of Obesity, looked at the long-term weight gain of more than 13,800 U.S. adults — a rare data point unearthed in obesity research. They found that more than half of American adults in the study gained 5% or more body weight over a 10-year period. What’s more, more than a third of American adults gained 10% or more body weight and almost a fifth gained 20% or more body weight.
The terrible science behind popular weight loss products
Dietary supplements and alternative therapies for weight loss have a limited high-quality evidence base of efficacy. Practitioners and patients should be aware of the scientific evidence of claims before recommending use.
https://www.inverse.com/mind-body/new-study-debunks-weight-loss-supplements
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China – ScienceDirect
“By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα.”
https://www.sciencedirect.com/science/article/pii/S0140673620301835
Understanding oxidants and antioxidants: Classical team with new players
We talk about antioxidants a lot. Much of our longevity supplements are in fact antioxidants but, what are antioxidants and what is oxidisation and, furthermore, why do we care about it?
Deuterium-Depleted Water, Water Filtration, Alkaline Water, & Much More!
Water, simple H2O right? Not quite. In this podcast, Ben Greenfield speaks with Robert Slovak about different types of water and possible benefits.
Antioxidant, antimicrobial and cytotoxic properties of four different extracts derived from the roots of Nicotianatabacum L. – ScienceDirect
“In the current study we demonstrate for the first time that organic extracts derived from the roots of N. tabacum possessed antioxidant, anticancer and antimicrobial properties. Our data draws attention to N. tabacum as a promising source of bioactive molecules that can be utilized in pharmaceutical industry, despite the fact that tobacco smoking is a major risk factor for lung cancer.”
https://www.sciencedirect.com/science/article/pii/S187638201930914X
Mitochondrial DNA stress signalling protects the nuclear genome – Science Mission
“Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or chemicals that can damage DNA, such as chemotherapy.”
LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway
“PP2A inhibition by LB100 significantly ameliorates hepatic steatosis by regulating hepatic lipogenesis and fatty acid oxidation via the AMPK/Sirt1 pathway. LB100 may be a potential therapeutic agent for NAFLD.”
Get $50 off an Oura ring
I do not make any claims about the Oura ring and I get nothing out of referring it other than to say that, it has helped me improve my sleep and provides a reasonable level of insight on your sleep and activity.
If you want to gain the same level of insight then go grab yourself an Oura ring for $50 off using the link below!
Urban Environmental Health – Map My Environment
“The VegeSafe program run by Macquarie University has been sampling backyard soil and household dust on behalf of homeowners across Sydney for several years.
They have now teamed up with researchers from seven countries across the globe to launch Map My Environment, an interactive tool allowing people to check levels of lead, arsenic and heavy metals in their suburb, based on more than 15,000 samples.” SMH Dec 1 2019
Health Hacker QandA
Do you have a question about a post here? Click the link below to join our slack channel where you can ask questions about new compounds and treatments posted.
We will try and respond or another community member may help with an answer. We will do our best to attend to your question however we cannot give specific medical advice, we can however share our own experiences so you have as much information as you can to make your own decision on a way forward.
https://join.slack.com/t/healthhackau
Modulation of hepatocyte sialylation drives spontaneous fatty liver disease and inflammation | Glycobiology | Oxford Academic
These findings connect hepatocyte and circulatory glycoprotein sialylation to the regulation of metabolism and inflammation, potentially identifying the glycome as a new target for liver-driven disease.
Modulation of hepatocyte sialylation drives spontaneous fatty liver disease and inflammation | Glycobiology | Oxford Academic
Get-Answers Service – Oliver Zolman
Deep Dyve Service
Get answers to any health question, in more detail than your clinicians or Dr Google can provide.
https://www.droliverzolman.com/get-answers-service
This is a paid service but not a paid referral.
These secret battles between your body’s cells might just save your life
Yasuyaki Fujita has seen first-hand what happens when cells stop being polite and start getting real. He caught a glimpse of this harsh microscopic world when he switched on a cancer-causing gene called Ras in a few kidney cells in a dish. He expected to see the cancerous cells expanding and forming the beginnings of tumours among their neighbours. Instead, the neat, orderly neighbours armed themselves with filament proteins and started “poking, poking, pokingâ€, says Fujita, a cancer biologist at Hokkaido University in Sapporo, Japan. “The transformed cells were eliminated from the society of normal cells,†he says, literally pushed out by the cells next door.
These secret battles between your body’s cells might just save your life
New method for quicker and simpler production of lipidated proteins
Decorating proteins with pharmaceuticals and other molecules for targeted delivery into the body and for keeping them active is an approach commonly used in medicine today. The method developed by Breinbauer and Becker could now be used to accurately and efficiently introduce such molecules into proteins. Breinbauer is confident that their method will soon be adopted because “the reagents we used are very easy to manufacture or can be purchased.”
New method for quicker and simpler production of lipidated proteins
Simplified Methylation Treatment Plan for Chronic Fatigue Syndrome (CFS) by Rich Van Konynenburg, Ph.D. – Health Rising
Although talking about chronic fatigue syndrome, it’s important to know about methylation especially if you’re supplementing with b group vitamins
Key concepts for making informed choices
This is not related to the subject of this blog however, it is a major focus of this blog to present only trustworthy information and to do so we apply some critical thinking to any sources we post here. We suggest everyone do the same.
Food, Inc.
This is a little old now but still a very pertinent documentary.
Declines in mental health associated with air pollution and temperature variability in China | Nature Communications
Opinion: I’ve always said that I’d rathwr do things to improve our environment and be wrong about climate change than to do the opposite. The potential risks are great but also the potential benefits to cleaning up our act could also be great. Here we have a paper showing causality between mental health decline and pollution levels.
FoundMyFitness Genetics – Genome Analysis Tool
https://www.foundmyfitness.com/genetics#
This tool does analisys of your dna results to help you understand any adjustments to your diet and lifestyle may be needed to account for gene mutations. The fee is a very modest $10 and run by Dr. Rhonda Patrick.
Quantum Theory Proves That Consciousness Moves To Another Universe After Death – Conscious Reminder
I’ve personally had this theory on my spiritual self for a while now. I’ve always thought that all this energy that we generate cannot just stop, it has to change form and continue. That’s physics.
Now we have this theory presented for your consideration.