Category: Glucose, Insulin & Diabetes
Overspill of fat shown to cause Type 2 Diabetes – Science Mission
Fatty liver? You’re possibly one step away from type 2 diabetes.
Keep an eye on your ALT levels. Ask your doc for a lipid profile blood test and check it today!
High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes. – PubMed – NCBI
“Mitochondria are fascinating structures of the cellular compartments that generate energy to run the cells. However, inherent disorders of mitochondria due to diabetes can cause major disruption of metabolism that produces huge amount of reactive oxygen species (ROS). Here we study the elevated level of ROS provoked by high glucose (HG) environment triggered mitochondrial dysfunction, inflammatory response and apoptosis via stress signalling pathway in keratinocytes. Our results demonstrated that elevated glucose level in keratinoctes, increase the accumulations of ROS and decrease in cellular antioxidant capacities.”
High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes. – PubMed – NCBI
Zinc supplementation improves glucose homeostasis in patients with β-thalassemia major complicated with diabetes mellitus: A randomized controlled trial – ScienceDirect
“Highlights
•The first study to assess the role of oral zinc supplementation in pediatric β-TM patients with DM.
•Zinc decreased hemolysis and iron burden.
•Zinc decreased FBG and HOMA-IR while increased fasting C peptide.
•Oral zinc improved glycemic control and decreased urinary albumin excretion.
•No adverse reactions were observed due to zinc supplementation.”
Zinc supplementation improves glucose homeostasis in patients with β-thalassemia major complicated with diabetes mellitus: A randomized controlled trial – ScienceDirect
Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice: Cell Metabolism
Chronic low-grade inflammation, particularly in adipose tissue, is an important modulator of obesity-induced insulin resistance. The Toll-like receptor 4 (Tlr4) is a key initiator of inflammatory responses in macrophages. We performed bone marrow transplantation (BMT) of Tlr4lps-del or control C57Bl/10J donor cells into irradiated wild-type C57Bl6 recipient mice to generate hematopoietic cell-specific Tlr4 deletion mutant (BMT-Tlr4−/−) and control (BMT-WT) mice. After 16 weeks of a high-fat diet (HFD), BMT-WT mice developed obesity, hyperinsulinemia, glucose intolerance, and insulin resistance. In contrast, BMT-Tlr4−/− mice became obese but did not develop fasting hyperinsulinemia and had improved hepatic and adipose insulin sensitivity during euglycemic clamp studies, compared to HFD BMT-WT controls. HFD BMT-Tlr4−/− mice also showed markedly reduced adipose tissue inflammatory markers and macrophage content. In summary, our results indicate that Tlr4 signaling in hematopoietic-derived cells is important for the development of hepatic and adipose tissue insulin resistance in obese mice.
Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size | SpringerLink
“Caloric restriction was effective in decreasing body and fat weights, total cholesterol and LDL. These effects were totally or partially reversed after 30 days of refeeding (groups GRL). During liver perfusion, the high glucose output of the GRs was further enhanced by adrenaline (1 μM), but not by lactate infusion. In contrast, in groups G6L, G12 L, G6RL and G12RL glycogenolysis (basal and adrenaline-stimulated glucose output) was low and gluconeogenesis from lactate was significant. A twofold increase in liver content of PKA in group G6R suggests that liver sensitivity to glucagon and adrenaline was higher because of caloric restriction, resulting in enhanced glucose output.”
Type 2 diabetes remission possible with ‘achievable’ weight loss — ScienceDaily
People who achieve weight loss of 10% or more in the first five years following diagnosis with type 2 diabetes have the greatest chance of seeing their disease go into remission, according to a study led by the University of Cambridge.
Type 2 diabetes remission possible with ‘achievable’ weight loss — ScienceDaily
High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily
Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content.
High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily
Metabolic discovery may help in fight against heart disease, diabetes
Researchers at Cornell University have uncovered a key step in how the human body metabolizes sugar, which could lead to better treatment and prevention of heart disease, obesity and Type 2 diabetes.
Metabolic discovery may help in fight against heart disease, diabetes