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age Archives - Health Hacker Australia

Tag: age

Resveralogues: From Novel Ageing Mechanisms to New Therapies? – Abstract – Gerontology – Karger Publishers

Resveralogues: From Novel Ageing Mechanisms to New Therapies? – Abstract – Gerontology – Karger Publishers

“For much of the 20th century the ageing process was thought to be the result of the interplay of many different biological processes, each with relatively small effects on organismal lifespan. However, this model is no longer tenable. Rather it seems a few biological mechanisms, including nutrient sensing, telomere attrition and cellular senescence, mediate large effects on health and longevity. Biogerontology may have suffered from initial delusions of complexity. However, we argue that it is premature to assume either that the list of biological processes influencing lifespan is now comprehensive or that these mechanisms act independently of each other.”

https://www.karger.com/Article/Abstract/504845

Centenarians: An excellent example of resilience for successful ageing – ScienceDirect

Centenarians: An excellent example of resilience for successful ageing – ScienceDirect

Highlights
• Centenarians maintain intrinsic capacity longer than individuals who display ordinary aging.

• Resilience is a determinant of health, and centenarians maintain it longer.

• Centenarians have specific genetic features.

https://www.sciencedirect.com/science/article/abs/pii/S0047637419302040

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation – ScienceDirect

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation – ScienceDirect

Highlights
• Tea-derived l-theanine inhibited AGE production in d-galactose-induced aging rats.

• l-Theanine increased FoxO1 expression and antioxidative enzymes in aged livers.

• l-Theanine could reduce oxygen free radicals and maintain the redox balance.

• l-Theanine supplementation could protect against age-related liver damage.

https://www.sciencedirect.com/science/article/pii/S0531556519306643

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing: Trends in Genetics

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing: Trends in Genetics

“Ageing is closely associated with and influenced by energy metabolism, and C/EBPβ is emerging as a key regulator of energy metabolism and longevity.”

https://www.cell.com/trends/genetics/fulltext/S0168-9525(19)30245-8?dgcid=raven_jbs_aip_email

Measuring biological aging in humans: A quest – Ferrucci – – Aging Cell – Wiley Online Library

Measuring biological aging in humans: A quest – Ferrucci – – Aging Cell – Wiley Online Library

“The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased risk of physical and cognitive disability. Improving or preserving the health and quality of life of these individuals is challenging due to a lack of well‐established clinical guidelines. Physicians are often forced to engage in cycles of “trial and error” that are centered on palliative treatment of symptoms rather than the root cause, often resulting in dubious outcomes. Recently, geroscience challenged this view, proposing that the underlying biological mechanisms of aging are central to the global increase in susceptibility to disease and disability that occurs with aging. In fact, strong correlations have recently been revealed between health dimensions and phenotypes that are typical of aging, especially with autophagy, mitochondrial function, cellular senescence, and DNA methylation. Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging. Understanding how the underlying biological mechanisms of aging connect to and impact longitudinal changes in health trajectories offers a unique opportunity to identify resilience mechanisms, their dynamic changes, and their impact on stress responses. Harnessing how to evoke and control resilience mechanisms in individuals with successful aging could lead to writing a new chapter in human medicine.”

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13080?utm_campaign=RESR_MRKT_Researcher_inbound&af=R&utm_medium=referral&utm_source=researcher_app

Identification of a key protein linked to ageing

Identification of a key protein linked to ageing

“These studies demonstrate an important link between the [pathological] accelerated ageing process and normal aging, and also expose the CSB protein as a key factor against cellular ageing” concludes Dr. Ricchetti.

https://medicalxpress.com/news/2019-12-identification-key-protein-linked-ageing.html