Tag: Analysis Forever Healthy Foundation

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Skin Rejuvenation by Low-Level Light Therapy

Skin Rejuvenation by Low-Level Light Therapy

Posted on by Nathan

Risk-Benefit Analysis

Forever Healthy Foundation gGmbH

Amalienbadstraße 41

D-76227 Karlsruhe, Germany

Low-level light therapy (LLLT) is the use of low incident levels of photon energy at a particular wavelength, targeting tissue to achieve a clinically useful local or systemic effect without the creation of heat (athermal) or damage (atraumatic) (Calderhead & Tanaka, 2017). LLLT has shown dramatic effects when used for wound healing, pain management, and various musculoskeletal conditions.

This review focuses on its potential use in skin rejuvenation. It has been shown that upon exposure to light, chromophores in the skin (mitochondrial cytochrome C, melanin, and protoporphyrins) absorb photons which lead to downstream alterations in physiology such as changes in cell proliferation, differentiation, migration, inflammatory mediators, and collagen production. It is supposed that these photobiomodulative effects have beneficial effects on the skin, leading to a more youthful appearance through increased collagen and elastin production, and a reduction in age spots and wrinkles. 

Key Questions 

This analysis seeks to answer the following questions:

  • Which benefits with regard to skin rejuvenation result from LLLT? 
  • Which risks are involved in using LLLT for skin rejuvenation (general and method-specific)?
  • What are the potential risk mitigation strategies?
  • Which method/device or combination of methods/devices is most effective for skin rejuvenation using LLLT?
  • Which of the available devices/methods are safe for use? 
  • What is the best therapeutic protocol available at the moment?  

https://brain.forever-healthy.org/display/EN/Skin+Rejuvenation+by+Low-Level+Light+Therapy

Fisetin Senolytic Therapy

Fisetin Senolytic Therapy

Posted on by Nathan

Risk-Benefit Analysis

Forever Healthy Foundation gGmbH

Amalienbadstraße 41

D-76227 Karlsruhe, Germany

Senolytics are agents that selectively induce apoptosis of senescent cells. Fisetin is a flavonoid polyphenol found in many types of fruits and vegetables (Arai et al., 2000) that is believed to act as a senolytic in addition to its numerous other known benefits. Although natural senolytics are less potent, compared to the targeted senolytics, they have lower toxicity and are thus, likely to be more readily translatable to clinical medicine. This RBA focuses on the risks and benefits of using fisetin as a senolytic rather than its more common use as a supplement.

Key Questions 

This RBA seeks to answer the following questions:

  • Which health and/or longevity benefits result from the use of fisetin as a senolytic? 
  • Which risks are involved in the use of fisetin as a senolytic (general and method-specific)?
  • What are the potential risk mitigation strategies?
  • Which method or combination of methods of using fisetin as a senolytic are most effective?
  • Which of the available methods are safe for use?
  • What is the best therapeutic protocol available at the moment?  

https://brain.forever-healthy.org/display/EN/Fisetin+Senolytic+Therapy

NAD+ Restoration Therapy

NAD+ Restoration Therapy

Posted on by Nathan

Risk-Benefit Analysis

Forever Healthy Foundation gGmbH

Amalienbadstraße 41

D-76227 Karlsruhe, Germany

NAD+ is a pyridine nucleotide found in all living cells. It plays an important role in energy metabolism and is a substrate for several enzymes (including those involved in DNA repair). NAD+ levels may decline markedly with age (Massudi et al., 2012; Clement et al., 2019; Zhu et al., 2011) and restoring those levels to a youthful state is believed to have beneficial effects on health and longevity. 

Key Questions 

This analysis seeks to answer the following questions:

  • Which health and/or longevity benefits result from raising NAD+ levels in humans? 
  • Which risks are involved in raising NAD+ levels (general and method-specific)?
  • What are the potential risk mitigation strategies?
  • Which method or combination of methods is most effective in raising NAD+ levels?
  • Which of the available methods are safe for use? 
  • What is the best therapeutic protocol available at the moment?  

https://brain.forever-healthy.org/display/EN/NAD+Restoration+Therapy