Search Results for: fisetin

Health Hacker Australia > Search results for 'fisetin'
Fisetin | | LEAF

Fisetin | | LEAF

Posted on by Nathan

“Fisetin, like many plant polyphenols, is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection. It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.

Finally, more recently, it has also shown promise as a senolytic, a compound that encourages aged or damaged senescent cells to destroy themselves rather than lingering in the body and contributing to the chronic, age-related inflammation known as “inflammaging”, which is associated with a wide range of age-related diseases.

Since fisetin has a good safety profile, Mayo Clinic followed these mouse studies by launching three trials to see if the compound is effective for humans.”

Human Clinical Trials with Fisetin:

Fisetin | | LEAF

Fisetin Senolytic Therapy

Fisetin Senolytic Therapy

Posted on by Nathan

Risk-Benefit Analysis

Forever Healthy Foundation gGmbH

Amalienbadstraße 41

D-76227 Karlsruhe, Germany

Senolytics are agents that selectively induce apoptosis of senescent cells. Fisetin is a flavonoid polyphenol found in many types of fruits and vegetables (Arai et al., 2000) that is believed to act as a senolytic in addition to its numerous other known benefits. Although natural senolytics are less potent, compared to the targeted senolytics, they have lower toxicity and are thus, likely to be more readily translatable to clinical medicine. This RBA focuses on the risks and benefits of using fisetin as a senolytic rather than its more common use as a supplement.

Key Questions 

This RBA seeks to answer the following questions:

  • Which health and/or longevity benefits result from the use of fisetin as a senolytic? 
  • Which risks are involved in the use of fisetin as a senolytic (general and method-specific)?
  • What are the potential risk mitigation strategies?
  • Which method or combination of methods of using fisetin as a senolytic are most effective?
  • Which of the available methods are safe for use?
  • What is the best therapeutic protocol available at the moment?  

https://brain.forever-healthy.org/display/EN/Fisetin+Senolytic+Therapy

Which supplements can help me live longer and healthier?

Posted on by Nathan

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

Continue reading “Which supplements can help me live longer and healthier?”

Eating to live…longer and healthier.

Posted on by Nathan

There are two main ways to provide the nutrients and the myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to use supplements and the other is to do it via food in our diet.

Here, in the first of our three part series on direct action for longevity, we explore the foods you can incorporate into your diet to get those identified goodies that keep us healthy for longer. We will also include herbs here as food as they require little to no handling to be beneficial and can be consumed as a food. Some of this is known via human clinical trial while some may be a mix of anecdotal use or animal studies. In all cases we take a can’t hurt, might help, approach and will either call out or exclude anything showing any risk of harm.

It’s important to note that, while all care is taken, we cannot guarantee the accuracy of this information and you should consult your health care professional before making changes in your diet and lifestyle.

Continue reading “Eating to live…longer and healthier.”
What is a stack and whats in one? – Opinion

What is a stack and whats in one? – Opinion

Posted on by Nathan

So you have a bunch of information on things that can help you live healthier and longer. What next?

Typically what a biohacker does is builds a stack. A stack is a collection of supplements that is aimed at a certain goal.

I’m going to give you some insight into my “pet rabbit” stack 😉 My rabbit is 104kgs and around 40 years old (Super Rabbit 😉 My rabbit is wanting to live healthier and longer as well as improve cognetive function and avoid cognitive decline. She wants to grow her hair and keep it a healthy colour and improve general health and fitness.

Firstly a dosing routine showing morning and evening dosing and which to take at what time of day for the desirable outcome.

Continue reading “What is a stack and whats in one? – Opinion”