Tag: healthspan

What lifestyle changes will help me live longer and healthier?

We’ve previously spoken about how we might introduce foods and supplements to our diet to improve health span and lifespan. Here we explore activities and other therapies that show potential in living healthier and longer. We also explore things you perhaps should stop doing to improve health and longevity.

Mitochondrial support

Mitochondria are organelles, basically, little functional units within cells, much like an organ is to our body. They provide power to our cells by delivering ATP to the cells and are thought to once be free-ranging bacteria. It is thought that the break down of mitochondrial function is one of, if not the main contributor to aging.

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Which supplements can help me live longer and healthier?

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

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Eating to live…longer and healthier.

There are two main ways to provide the nutrients and the myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to use supplements and the other is to do it via food in our diet.

Here, in the first of our three part series on direct action for longevity, we explore the foods you can incorporate into your diet to get those identified goodies that keep us healthy for longer. We will also include herbs here as food as they require little to no handling to be beneficial and can be consumed as a food. Some of this is known via human clinical trial while some may be a mix of anecdotal use or animal studies. In all cases we take a can’t hurt, might help, approach and will either call out or exclude anything showing any risk of harm.

It’s important to note that, while all care is taken, we cannot guarantee the accuracy of this information and you should consult your health care professional before making changes in your diet and lifestyle.

Continue reading “Eating to live…longer and healthier.”

Why 80 Percent of New Year’s Resolutions Fail

A new year, and a new decade lay before us as we reach the end of 2019.

You’re inspired to start improving something about your health of life.

Don’t, well, more accurately do, but don’t do it for a new years resolution.

Do it because you are ready, do it because you’re done with the status quo, do it for your happiness, for your family.

Do it for any reason other than an arbitrary date with artificial importance projected upon it.

Changes are hard and habits are strong. It takes time and conviction to change so you need to be truly ready and you need to do it as soon as you can.

If you set yourself a new years resolution and fail you are likely to give up completely or revert back to comfort to relive the disappointment and depression that may follow a failed new years resolution.

Know that you have it in you to change without an arbitrary date. You can do it!

from:

https://health.usnews.com/health-news/blogs/eat-run/articles/2015-12-29/why-80-percent-of-new-years-resolutions-fail

12 Ways To Upgrade Your Lifespan & Healthspan IQ

12 Ways To Upgrade Your Lifespan & Healthspan IQ

The amount of time we live is called lifespan. The length of time that a person is healthy and functional—not just alive—is called healthspan. Scientific understanding in these areas is advancing rapidly. Below are 12 things the collective thinks will help on your journey to a longer healthier you. 

1. BOOST NAD+ LEVELS

2. POWER UP WITH ATP

3. CREATE FIT MITOCHONDRIA

4. ACTIVATE AMPK

5. CALORIE RESTRICTION AND CALORIE RESTRICTION MIMETICS

6. EXERCISE AND EXERCISE MIMETICS

7. BODY CLOCK 

8. FOLLOW A HEALTHY AGING EXPERT

12 Ways To Upgrade Your Lifespan & Healthspan IQ

Growth Hormone DHEA Metformin In Aging Clinical Study

Growth Hormone DHEA Metformin In Aging Clinical Study

“A new clinical trial found that a combination of Growth Hormone, DHEA & Metformin helped to restore the size of the thymus gland and reverse biological age (epigenetic age via the GrimAge test).”

➢ Link to study:

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., et al. (2019). Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell, 18(6), 421–12. http://doi.org/10.1111/acel.13028

https://highintensityhealth.com/growth-hormone-dhea-metformin-in-aging-clinical-study/

Watch “The Secret to Aging in Reverse Revealed by Harvard Professor | David Sinclair” on YouTube

Watch “The Secret to Aging in Reverse Revealed by Harvard Professor | David Sinclair” on YouTube

NMN – Nicotinimide Mononucleotide

NMN – Nicotinimide Mononucleotide

MIB-626, the NAD+ precursor that’s superior to NMN
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
The elusive NMN transporter is found | Nature Metabolism
David Sinclair – Can NMN Reverse Aging? – YouTube
Effect of “Nicotinamide Mononucleotide” (NMN) on Cardiometabolic Function – Full Text View – ClinicalTrials.gov
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
Resveratrol

Resveratrol

Trans-Resveratrol
Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More
Exploring the effect of fasting on age-related diseases — ScienceDaily
Metformin

Metformin

This cheap pill might help you live a longer, healthier life
Metformin as Anti-Aging Therapy: Is It for Everyone?: Trends in Endocrinology & Metabolism
Full title: High glucose protects mesenchymal stem cells from metformin-induced apoptosis through the AMPK-mediated mTOR pathway | Scientific Reports
Diabetes drug has unexpected, broad implications for healthy aging
Mitochondrial targets of metformin-Are they physiologically relevant? – PubMed – NCBI
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy: Cell
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus | Nature Reviews Endocrinology
H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses | Cell Death & Disease
Pro-neurocognitive and Anti-sarcopenic benefits of one-year Metformin therapy in ovariectomized aged mice. – PubMed – NCBI

Risks: this risk is low (less than 10 cases for 100,000 patient years), but the risk of metformin-induced lactic acidosis (MALA) increases in certain situations where both the plasma levels of metformin are increased and lactate clearance is impaired.[6]