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lifespan Archives - Health Hacker Australia

Tag: lifespan

Longevity, healthspan and aging: what you need to know

Longevity, healthspan and aging: what you need to know

As you age, it’s important to focus on maintaining your health and wellbeing. This means eating a healthy diet, getting regular exercise and ensuring you’re taking care of your mental health. But what about your physical health? What can you do to ensure you live a long, healthy life?

There are many things you can do to improve your lifespan and healthspan. Here are some of the most important:

  1. Eat a balanced diet

A balanced diet is key to good health. It’s important to include plenty of fresh fruits and vegetables in your diet, as well as whole grains, lean protein and healthy fats. Avoid processed foods and sugary drinks whenever possible.

  1. Get regular exercise

Exercise is essential for good health. It helps keep your body strong and healthy, and it can also help protect against diseases such as cancer. Aim for at least 30 minutes of exercise per day, five days per week.

  1. Take care of your mental health

Mental health is just as important as physical health. Taking care of your mental wellbeing can help protect against conditions such as anxiety and depression. Make sure you take some time for yourself each day to relax and de-stress. And if you’re experiencing any problems with your mental health, be sure to seek professional help.

  1. Stay hydrated

It’s important to stay hydrated by drinking plenty of water throughout the day. Dehydration can lead to a number of problems, including fatigue, headaches and dizziness. Drink at least eight glasses of water per day to stay hydrated.

  1. Get enough sleep

Getting enough sleep is essential for good health. Adults should aim for around eight hours of sleep each night. Poor sleep can lead to a number of problems, including fatigue, stress and anxiety.

  1. Take supplements if needed

In some cases, supplements may be necessary in order to maintain good health. Omega-3 fatty acids are a good example – many people don’t get enough omega-3s from their diet, so taking a supplement can be beneficial. Consult with your doctor before starting any new supplements, however – not all supplements are safe for everyone to take.

  1. Consider nmn therapy

nmN therapy is a novel treatment that uses neural modulation to improve cellular function and promote longevity [1]. The therapy involves injecting nmN into specific areas of the brain in order to promote cell rejuvenation [2]. so far, studies have shown that nmN therapy can improve cognitive function, increase lifespan and protect against age-related diseases [3].

8 . Consider rapamicin therapy

Rapamicin is a drug that has been shown to increase lifespan in animals [4]. It works by inhibiting the mTOR pathway, which is responsible for cell growth and aging [5]. Rapamicin has been shown to delay the onset of age-related diseases such as cancer and heart disease [6], and it may also be able to improve cognitive function [7].

9 . Consider metformin therapy

Metformin is a drug that is commonly used to treat diabetes [8]. However, research suggests that it may also have anti-aging properties [9]. One study found that metformin was able to extend the lifespan of worms by up to 50% [10]. Another study showed that metformin was able to reduce the risk of death from all causes in patients with type 2 diabetes [11] . While more research is needed on the anti-aging effects of metformin, it’s possible that this drug could play an important role in extending lifespan in humans .

What lifestyle changes will help me live longer and healthier?

We’ve previously spoken about how we might introduce foods and supplements to our diet to improve health span and lifespan. Here we explore activities and other therapies that show potential in living healthier and longer. We also explore things you perhaps should stop doing to improve health and longevity.

Mitochondrial support

Mitochondria are organelles, basically, little functional units within cells, much like an organ is to our body. They provide power to our cells by delivering ATP to the cells and are thought to once be free-ranging bacteria. It is thought that the break down of mitochondrial function is one of, if not the main contributor to aging.

Continue reading “What lifestyle changes will help me live longer and healthier?”

Which supplements can help me live longer and healthier?

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

Continue reading “Which supplements can help me live longer and healthier?”

Eating to live…longer and healthier.

There are two main ways to provide the nutrients and the myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to use supplements and the other is to do it via food in our diet.

Here, in the first of our three part series on direct action for longevity, we explore the foods you can incorporate into your diet to get those identified goodies that keep us healthy for longer. We will also include herbs here as food as they require little to no handling to be beneficial and can be consumed as a food. Some of this is known via human clinical trial while some may be a mix of anecdotal use or animal studies. In all cases we take a can’t hurt, might help, approach and will either call out or exclude anything showing any risk of harm.

It’s important to note that, while all care is taken, we cannot guarantee the accuracy of this information and you should consult your health care professional before making changes in your diet and lifestyle.

Continue reading “Eating to live…longer and healthier.”
Mitochondrial Haplogroups and Lifespan in a Population Isolate – ScienceDirect

Mitochondrial Haplogroups and Lifespan in a Population Isolate – ScienceDirect

“The lifespan-lengthening association was apparent in both sexes but only after the age of 60. Our results provide further support for the role of mitochondrial genetics in lengthening human lifespan.”

https://www.sciencedirect.com/science/article/abs/pii/S1567724919301047

Maf1‐dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan – Shetty – – Aging Cell – Wiley Online Library

Maf1‐dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan – Shetty – – Aging Cell – Wiley Online Library

Fundamental cellular mechanisms such as nutrient sensing, DNA damage response pathways, and cell cycle regulation influence the aging process. Studies have shown that the nutrient sensory kinase, mTOR (TOR in yeast), regulates lifespan in response to nutrient availability. The mTOR kinase forms two distinct protein complexes: TORC1 and TORC2. TORC1, which is inhibited by rapamycin, regulates cell growth, proliferation, and metabolism. It is well established that TORC1 promotes protein translation via phosphorylation of ribosomal protein S6 kinase and the eIF4E‐binding protein (BP; Zoncu, Efeyan, & Sabatini, 2011). The TORC2 branch is less studied; however, TORC2 also plays important roles in metabolism, cell survival, and proliferation (Zoncu et al., 2011). Although the involvement of the TORC1 pathway in lifespan regulation is conserved among many species (i.e., TORC1 inhibition extends lifespan), it is still unclear how this pathway affects multiple downstream stress and damage response mechanisms.

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13068?utm_campaign=RESR_MRKT_Researcher_inbound&af=R&utm_medium=referral&utm_source=researcher_app

Metformin

Metformin

Risks: this risk is low (less than 10 cases for 100,000 patient years), but the risk of metformin-induced lactic acidosis (MALA) increases in certain situations where both the plasma levels of metformin are increased and lactate clearance is impaired.[6]