“Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.”
“Fatty liver, or hepatic steatosis, which develops when the body produces too much fat or doesn’t metabolize fat efficiently enough, affects around 25% of the global population. Excess fat is stored in liver cells, where it accumulates and can cause fatty liver and other diseases.
In a study just published in the journal Cell Reports, researchers reveal for the first time that SIRT6, a protein involved in regulating many biological processes such as aging, obesity, insulin resistance, inflammation and metabolism, also plays a crucial role in burning and regulating liver fat metabolism.”
Highlights
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From meta-analysis of RCTs in Alzheimer’s disease and Mild Cognitive Impairment, oral Medium Chain Triglycerides administration induced mild peripheral ketosis
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From meta-analysis of RCTs in Alzheimer’s disease and Mild Cognitive Impairment, oral Medium Chain Triglycerides administration improved cognition on a combined scale of ADAS-Cog and MMSE.
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Risk of bias of existing studies of RCTs in Alzheimer’s disease and Mild Cognitive Impairment necessitates future trials.
https://www.sciencedirect.com/science/article/pii/S156816371930131X
Highlights
•Potassium (K+) channels are key regulators of cell excitability in several tissues.
•A dysregulation of K+ channels is associated with Alzheimer’s disease (AD).
•The role of K+ channels in AD is not completely elucidated.
•Understanding their functions will be helpful for clarifying AD pathogenesis.
•Modulating K+ channel expression should be useful for developing novel drugs.
Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update – ScienceDirect
“Aging is an important risk factor for several human diseases such as cancer, cardiovascular disease and neurodegenerative disorders, resulting from a combination of genetic and environmental factors (e.g., diet, smoking, obesity and stress), which, at molecular level, cause changes in gene expression underlying the decline of physiological function. Epigenetics, which include mechanisms regulating gene expression independently of changes to DNA sequence, regulate gene expression by modulating the structure of chromatin or by regulating the binding of transcriptional machinery to DNA. Several studies showed that an impairment of epigenetic mechanisms promotes alteration of gene expression underlying several aging-related diseases. Alteration of these mechanisms is also linked with changes of gene expression that occurs during aging processes of different tissues. In this review, we will outline the potential role of epigenetics in the onset of two age-related pathologies, cancer and cardiovascular diseases.”
“Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.”
“The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled.”
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-019-0317-2