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review Archives - Health Hacker Australia

Tag: review

Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

” We reviewed and discussed underlying mechanisms of CR from an aspect of CR genes. It should be stressed that the isoform specificity of FoxO transcription factors for longevity becomes apparent under CR conditions but not AL conditions. Npy and FoxO1 both play pleiotropic roles in aging and related disorders, depending on the nutritional state. As briefly described in Section 1 and Section 2, the life-extending effects of CR and reduced IGF-1 signaling are also sexually dimorphic. Genes associated with regulation of the aging process should be investigated carefully in a context-dependent manner, i.e., abilities of physiological adaptation for individuals against environmental challenges, particularly food shortage. “

https://www.mdpi.com/2072-6643/11/12/3068/htm

The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis

The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis

We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in participants >18 years old, metformin intake significantly increased IGF-1. We suggest that caution be taken when interpreting the findings of this review, particularly given the discordant supplementation practices between children and adults.

https://www.sciencedirect.com/science/article/abs/pii/S104366181932081X?dgcid=rss_sd_all&utm_campaign=RESR_MRKT_Researcher_inbound&utm_medium=referral&utm_source=researcher_app

Epigenetics of aging and disease: a brief overview. – PubMed – NCBI

Epigenetics of aging and disease: a brief overview. – PubMed – NCBI

“Aging is an important risk factor for several human diseases such as cancer, cardiovascular disease and neurodegenerative disorders, resulting from a combination of genetic and environmental factors (e.g., diet, smoking, obesity and stress), which, at molecular level, cause changes in gene expression underlying the decline of physiological function. Epigenetics, which include mechanisms regulating gene expression independently of changes to DNA sequence, regulate gene expression by modulating the structure of chromatin or by regulating the binding of transcriptional machinery to DNA. Several studies showed that an impairment of epigenetic mechanisms promotes alteration of gene expression underlying several aging-related diseases. Alteration of these mechanisms is also linked with changes of gene expression that occurs during aging processes of different tissues. In this review, we will outline the potential role of epigenetics in the onset of two age-related pathologies, cancer and cardiovascular diseases.”

https://www.ncbi.nlm.nih.gov/pubmed/31811572?dopt=Abstract

Impact of isocaloric exchanges of carbohydrate for fat on postprandial glucose, insulin, triglycerides, and free fatty acid responses

Impact of isocaloric exchanges of carbohydrate for fat on postprandial glucose, insulin, triglycerides, and free fatty acid responses

—a systematic review and meta-analysis | European Journal of Clinical Nutrition

https://www.nature.com/articles/s41430-019-0534-6