Tag: memory

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 + T-cell memory development | Nature Cell Biology

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 + T-cell memory development | Nature Cell Biology

“Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual metabolic program raises the question of how Pck1 is upregulated in CD8+ Tmem cells. Here, we show that mitochondrial acetyl coenzyme A is diverted to the ketogenesis pathway, which indirectly regulates Pck1 expression. Mechanistically, ketogenesis-derived β-hydroxybutyrate is present in CD8+ Tmem cells; β-hydroxybutyrate epigenetically modifies Lys 9 of histone H3 (H3K9) of Foxo1 and Ppargc1a (which encodes PGC-1α) with β-hydroxybutyrylation, upregulating the expression of these genes.”

https://www.nature.com/articles/s41556-019-0440-0?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Exercise Intervention Helps Slow Down Memory Loss – Conduct Science

Exercise Intervention Helps Slow Down Memory Loss – Conduct Science

“Mild cognitive impairment or cognitive impairment without dementia (CIND) is a health condition elderly people suffer from.
The condition causes memory loss and in extreme cases, it can progress to Alzheimer’s disease.
A new study shows that exercise may help elevate symptoms of the condition.”

https://conductscience.com/exercise-intervention-helps-slow-down-memory-loss/