Category: ADHD

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Autism Spectrum Disorder and ADHD with The Low Dose Naltrexone

Autism Spectrum Disorder and ADHD with The Low Dose Naltrexone

Posted on by Nathan

Endorphins and Autism

Some researchers have suggested that excessive opioid activity in autistic children causes them to engage in repetitive “self-stimulatory” and self-injurious behaviours to further stimulate the pain-induced release of endogenous opiates. This hypothesis resulted in many trials using the opioid antagonist naltrexone. The action of naltrexone is to block opioid receptors thus creating a rebound effect of increased endorphin release, which in turn modulates the immune response, reducing cytokines and so reducing inflammation.3

In several of these trials naltrexone helped to increase socialisation, eye contact, pain sensitivity and a decrease in self-injurious/stimulatory behaviours. Endorphins are not the only neurotransmitters thought to be involved in autism, serotonin and dopamine are also found in abnormal concentrations which are likely to contribute to the condition.4

The use of Low Dose Naltrexone for children with autism spectrum disorders was studied in the 1990’s with researchers using from 5 mg to 50 mg daily. Many researchers noted better results with lower doses.

While not presenting the ultimate answer in the treatment of autism, naltrexone is shown to help alleviate some of the symptoms modulated by endogenous opioids.

https://ldnresearchtrust.org/autism-spectrum-disorder-and-promising-treatment-low-dose-naltrexone-paula-johnson

ADHD and Low Dose Naltrexone (LDN)

How about ADHD in an adult, and at what doses? Absolutely! I mean if it works in children, we might not use it in adults. We would still use typical dosing that we would use for pretty much anything else. You could start anywhere from 0.5 to 1.5, slowly increase the dose, and then top out at the maximum of 4.5 once a day. Not everybody gets to 4.5, and again that’s where working very closely with your medical professionals is going to help you find your happy dose.

https://ldnresearchtrust.org/adhd-and-low-dose-naltrexone-ldn

Frontiers | ADHD and Neurodegenerative Disease Risk: A Critical Examination of the Evidence

Frontiers | ADHD and Neurodegenerative Disease Risk: A Critical Examination of the Evidence

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These studies present first evidence of a link between ADHD and risk of dementia, specific to LBD. Strengths include well-powered analyses and extensive follow-up periods (>10 years) in most studies. However, six (Curtin et al., 2018; Fluegge and Fluegge, 2018; Tzeng et al., 2019; Fan et al., 2020; Du Rietz et al., 2021; Zhang et al., 2021) rely on ICD diagnostic codes extracted from electronic health records, and there are limitations around the validity and accuracy of these codes, particularly for a disorder that is notoriously difficult to detect in adults (Newcorn et al., 2007; Ginsberg et al., 2014). The remaining two (Walitza et al., 2007; Golimstok et al., 2011) are limited by potentially biased and inaccurate self-reported retrospective childhood ADHD symptoms in small samples of cognitively impaired participants.

https://www.frontiersin.org/articles/10.3389/fnagi.2021.826213/full

Individualization of attention-deficit/hyperactivity disorder treatment: pharmacotherapy considerations by age and co-occurring conditions

Individualization of attention-deficit/hyperactivity disorder treatment: pharmacotherapy considerations by age and co-occurring conditions

Posted on by Nathan

One publication to explain all medications related to treatment of adhd by age.

Individualization of attention-deficit/hyperactivity disorder treatment: pharmacotherapy considerations by age and co-occurring conditions https://link.researcher-app.com/sgkq – via Researcher (@ResearcherApp)

The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD

The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD

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The latest research cumulates staggering information about the correlation between the microbiota-gut-brain axis and neurodevelopmental disorders. This review aims to shed light on the potential influence of the microbiome on the development of the most prevalent neurodevelopmental disease, attention-deficit-hyperactive disorder (ADHD). As the etiology and pathophysiology of ADHD are still unclear, finding viable biomarkers and effective treatment still represent a challenge. Therefore, we focused on factors that have been associated with a higher risk of developing ADHD, while simultaneously influencing the microbial composition. We reviewed the effect of a differing microbial makeup on neurotransmitter concentrations important in the pathophysiology of ADHD. Additionally, we deduced factors that correlate with a high prevalence of ADHD, while simultaneously affecting the gut microbiome, such as emergency c-sections, and premature birth as the former leads to a decrease of the gut microbial diversity and the latter causes neuroprotective Lactobacillus levels to be reduced. Also, we assessed nutritional influences, such as breastfeeding, ingestion of short-chain fatty acids (SCFAs) and polyunsaturated fatty acids (PUFAs) on the host?s microbiome and development of ADHD. Finally, we discussed the potential significance of Bifidobacterium as a biomarker for ADHD, the importance of preventing premature birth as prophylaxis and nutrition as a prospective therapeutic measurement against ADHD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893446/

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications – PubMed

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications – PubMed

Posted on by Nathan

Studies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (CNS), or so-called the microbiome-gut-brain axis (MGBA), is involved in diverse neuropsychiatric diseases in children and adults. In pediatric age, most studies have focused on patients with autism. However, evidence of the role played by the MGBA in attention deficit/hyperactivity disorder (ADHD), the most common neurodevelopmental disorder in childhood, is still scanty and heterogeneous.

https://pubmed.ncbi.nlm.nih.gov/33467150/

Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics

Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics

Posted on by Nathan

DMNS has a good effect in treating ADHD, and it may exert this effect by regulating the gut microbiota and affecting metabolites in the peripheral circulation.

Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics https://link.researcher-app.com/kZmz – via Researcher (@ResearcherApp)

ADHD & Autism: Similarities, Differences, & Treating Co-Occurences

ADHD & Autism: Similarities, Differences, & Treating Co-Occurences

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“Both autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are conditions where the development of the brain has been affected in some way. This is known as a neurodevelopment disorder.

This means that both ASD and ADHD affect the central nervous system, potentially impacting social and focusing skills, language, movement, and memory. Much research has established that the two conditions typically coexist in patients, but there is no conclusive evidence to suggest why this is.”

https://www.elemy.com/studio/mood-disorders/adhd-and-autism/

Twice Exceptional: Gifted & Challenged with ADHD and More

Twice Exceptional: Gifted & Challenged with ADHD and More

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“Twice exceptional” (2e) is the term used to describe intellectually gifted children with great potential for academic achievement who also have a learning disability or neurological challenge, like attention deficit hyperactivity disorder (ADHD or ADD). Their exceptional intellectual abilities of 2e students are often masked or obscured by one or several conditions (or vice versa), making them one of the least recognized and supported populations.

https://www.additudemag.com/twice-exceptional-adhd-signs/

L-Tyrosine+L-Theanine +Coffee bean&berry as Possible ADHD treatment pathway

L-Tyrosine+L-Theanine +Coffee bean&berry as Possible ADHD treatment pathway

Posted on by Nathan

Personal anecdote/not sponsored:

In our quest to find the most effective and healthy options in treating conditions, we’ve come across an interesting supplement based mainly on caffine, coffee beans, L-theanine, and L-tyrosine.

Our head researcher has both ADHD and ASD (Autism Spectrum Disorder). Traditional medication used in ADHD treatment has been deficient, until now.

The clarity and calm that is had via this particular supplement has made one of the single biggest changes for him. This may be an option for others wishing to find a more effective treatment, or to make a change away from their current regime.

As always, exercise caution when making changes to your medication, and discuss with your health care professionals.


A closer look at the key nootropics:

Alpha GPC (L-Alpha Glycerylphosphorylcholine) – a cholinergic compound that regulates a neurotransmitter called Acetylcholine, that supports physical and mental performance.
Huperzine A – a compound found in Chinese club moss, increases the neurotransmitter Acetylcholine, supporting memory, focus and brain health.
Ginseng – derived from a fleshy plant root; Ginseng is natural energy support used in Chinese medicine for centuries. This herb can help sharpen your mind and support relaxation simultaneously.
L-Theanine – if you’ve had green tea, you’ve had L-Theanine! This amino acid helps give you a mental boost without the jitters and is now a popular component of many pre-workout formulas.
L-Tyrosine – Your neurotransmitters (such as Dopamine) rely on nonessential amino acids like L-Tyrosine. It assists communication between nerve cells, helping your brain to function with clarity and assisting the healthy stress response.
Bacopa Monnieri (Brahmi) – traditionally used in Ayurvedic medicine, this herb supports focus, learning and memory.

https://athleticsport.com.au/blogs/blog/what-are-the-best-nootropics

Nootopia Nootropic

References

Bellar D, LeBlanc NR, Campbell B. The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength. J Int Soc Sports Nutr. 2015;12:42. Published 2015 Nov 17. doi:10.1186/s12970-015-0103-x

Frank, K., Patel, K., Lopez, G. and Willis, B., 2020. Theanine Research Analysis. [online] Examine.com.

Here, S., Guide, N., Nootropics, L., Nootropics, B. and Take, W., 2020. The Definitive Guide To Nootropics – Nootropics Expert. [online] Nootropicsexpert.com.

Parker, A.G., Byars, A., Purpura, M. et al. The effects of Alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. J Int Soc Sports Nutr 12, P41 (2015). https://doi.org/10.1186/1550-2783-12-S1-P41

Noor Azuin Suliman, Che Norma Mat Taib, Mohamad Aris Mohd Moklas, Mohd Ilham Adenan, Mohamad Taufik Hidayat Baharuldin, Rusliza Basir, “Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic”,Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 4391375, 12 pages, 2016. https://doi.org/10.1155/2016/4391375

Working Conditions, Work Productivity, Quality of Life, and Depressive Symptoms in Undiagnosed Adults with and without Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms During the COVID-19 Pandemic

Working Conditions, Work Productivity, Quality of Life, and Depressive Symptoms in Undiagnosed Adults with and without Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms During the COVID-19 Pandemic

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Productivity was improved among all participants during the COVID-19 pandemic, contrary to expectations. However, adults with ADHD symptoms consistently had lower productivity, poorer QOL, and more depressive symptoms than those without ADHD symptoms.

Working Conditions, Work Productivity, Quality of Life, and Depressive Symptoms in Undiagnosed Adults with and without Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms During the COVID-19 Pandemic https://link.researcher-app.com/TFUE – via Researcher (@ResearcherApp)

Cognitive deficit in adults with ADHD lies in the cognitive state disorder rather than the working memory deficit: A functional near-infrared spectroscopy study

Cognitive deficit in adults with ADHD lies in the cognitive state disorder rather than the working memory deficit: A functional near-infrared spectroscopy study

Posted on by Nathan

This study tested whether cognitive deficit in patients with adult attention deficit hyperactivity disorder (ADHD) is a working memory deficit or cognitive state disorder during the N-back task. Twenty-two adults with ADHD and twenty-four healthy controls participated in the N-back task. The functional near-infrared spectroscopy (fNIRS) was combined with three perspectives from behavioral and spatial and temporal activation characteristics of blood oxygen levels in the prefrontal cortex to examine the psychological and neuroprocessing characteristics of adult ADHD. Data were acquired using a block design during an N-back task with three memory loads. Visual stimuli were presented on a computer monitor. Behaviorally, response time and accuracy showed no significant differences between the two groups. Spatially, in the left orbitofrontal area and the left frontopolar area (Channels 4 and 11), adult ADHD had significantly higher activation levels of oxyHb in the 2-back task and lower activation levels of deoxyHb in the 3-back task than healthy controls (corrected p?<?0.05). Therefore, Channel 4 in the 2-back condition and Channel 11 in the 3-back condition were used as the regions of interest (ROI). Temporally, adults with ADHD peaked earlier in the ROIs than healthy controls. Furthermore, working memory deficit was not found directly from the behavioral performance in adult ADHD. However, adult ADHD can be affected by memory load, task duration, and novelty stimulus. Our findings suggest that patients with adult ADHD have cognitive state disorder instead of working memory deficit.

Cognitive deficit in adults with ADHD lies in the cognitive state disorder rather than the working memory deficit: A functional near-infrared spectroscopy study https://link.researcher-app.com/wbqx – via Researcher (@ResearcherApp)

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

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Attention-deficit/hyperactivity disorder (ADHD) is a common and debilitating neurodevelopmental disorder influenced by both genetic and environmental factors, typically identified in the school-age years but hypothesized to have developmental origins beginning in utero. To improve current strategies for prediction, prevention and treatment, a central challenge is to delineate how, at a molecular level, genetic and environmental influences jointly shape ADHD risk, phenotypic presentation, and developmental course. Epigenetic processes that regulate gene expression, such as DNA methylation, have emerged as a promising molecular system in the search for both biomarkers and mechanisms to address this challenge.

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential https://link.researcher-app.com/DmeY – via Researcher (@ResearcherApp)

Brain imaging reveals ADHD as a collection of different disorders — ScienceDaily

Brain imaging reveals ADHD as a collection of different disorders — ScienceDaily

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Researchers have found that patients with different types of attention-deficit/hyperactivity disorder (ADHD) have impairments in unique brain systems, indicating that there may not be a one-size-fits-all explanation for the cause of the disorder. Based on performance on behavioral tests, adolescents with ADHD fit into one of three subgroups, where each group demonstrated distinct impairments in the brain with no common abnormalities between them.

https://www.sciencedaily.com/releases/2017/11/171107140834.htm

Episode 108 – Brain vs Gut — ATP Science USA

Episode 108 – Brain vs Gut — ATP Science USA

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In today podcast Jeff, Matt and Steve delve straight back into gut health and its relationship to the brain, your immune systems and hormone production specifically Serotonin. Steve breaks out some new research showing the impact of serotonin in the gut and its affects on ADHD and Parkinson’s. While Matt shares some information on polyphenols and the results of his new gut product prototype. The boys answer some FAQ’s on Hirsutism, and PCOS, Banana rolls which are the rolls under the bum of a bikini competitor and her battle with cellulite, Glucose disposal agents and a sufferer from a chronic allergic reaction As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle

Source: Episode 108 – Brain vs Gut — ATP Science USA