Category: Mycelium and Mushrooms
Frontiers | The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action | Pharmacology
Psilocybin (O-phosphoryl-4hydroxy-N, N-dimethyltryptamine) and its active metabolite psilocin (4-hydroxy-N, N-dimethyltryptamine) are the main psychoactive components of psychedelic mushrooms. In the central nervous system, psilocin acts as an agonist of serotonergic 5-HT1A and 5-HT2A/C receptors, leading to altered states of consciousness in humans (Tyls et al., 2014). Psilocybin doses of 0.04–0.43 mg/kg cause alterations in perception, cognition, and emotions, while also eliciting long-term changes in well-being and mood in both healthy and psychiatric subjects (Dos Santos et al., 2016; Kor?ák et al., 2019; Barrett et al., 2020). These long-lasting positive changes lead to an exploration of the therapeutic potential of psychedelics as well as the mechanisms underlying this potential. Because of its general safety, intermediate duration of action, and therapeutic potential in several neuropsychiatric disorders, psilocybin is currently the most intensely studied psychedelic in clinical trials (Sewell et al., 2006; Grob et al., 2011; Stebelska, 2013; Dos Santos, 2014).
Overall, there has been an increasing preclinical (Catlow et al., 2013; Baumeister et al., 2014) and clinical (Carhart-Harris et al., 2016; Bogenschutz and Ross, 2018) evidence for the antidepressant potential of psilocybin. Although exact mechanisms are currently unknown, it is generally believed to be attributed to either a direct action on 5-HT receptors or the psychological effects of acute intoxication (Carhart-Harris and Goodwin, 2017). It has been shown that serotonergic psychedelics including psilocybin via 5-HT2A receptors promote neuroplasticity (Ly et al., 2018), a fundamental mechanism of neuronal adaptation that is disrupted in depression (Carhart-Harris and Goodwin, 2017) and restored by antidepressant treatments including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) or electroconvulsive therapy (ECT) (Hayley and Littlejohn, 2013).
https://www.frontiersin.org/articles/10.3389/fphar.2020.602590/full
The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model
“Hericium erinaceus, an edible and medicinal mushroom, displays various pharmacological activities in the prevention of dementia in conditions such as Parkinson’s and Alzheimer’s disease. The present study explored the neuroprotective effects of H. erinaceus mycelium polysaccharide-enriched aqueous extract (HE) on an l-glutamic acid (l-Glu)-induced differentiated PC12 (DPC12) cellular apoptosis model and an AlCl3 combined with d-galactose-induced Alzheimer’s disease mouse model.”
Improvement of cognitive function… preview & related info | Mendeley
“MMSE alone showed that oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration.”
https://www.mendeley.com/catalogue/improvement-cognitive-functions-oral-intake-hericium-erinaceus/
Antimicrobial properties of Fomitopsis officinalis (Agarikon Mushroom) in the light of its bioactive metabolites: a review: Mycology: Vol 10, No 1
“According to several reports there is evidence of a broad-spectrum antibacterial and antiviral activity by F. officinalis, including pathogens like Mycobacterium tuberculosis, Yersinia pseudotuberculosis and Staphylococcus aureus, as well as Ortopox virus.”
https://www.tandfonline.com/doi/full/10.1080/21501203.2018.1536680
Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice
“Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE administration, all mice except the control group went through with 14 days of RS protocol. Stressed mice exhibited various behavioral alterations, such as extending immobility time in the tail suspension test (TST) and forced swimming test (FST), and increasing the number of entries in open arm (POAE) and the time spent in the open arm (PTOA). Moreover, the levels of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) were decreased in the stressed mice, while the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α were increased. These changes were significantly inverted by the administration of HE, especially at the dose of 200 or 400 mg/kg body weight/day. Additionally, HE was shown to activate the BDNF/TrkB/PI3K/Akt/GSK-3β pathways and block the NF-κB signals in mice. Taken together, erinacine A-enriched HE mycelium could reverse the depressive-like behavior caused by RS and was accompanied by the modulation of monoamine neurotransmitters as well as pro-inflammatory cytokines, and regulation of BDNF pathways. Therefore, erinacine A-enriched HE mycelium could be an attractive agent for the treatment of depressive disorders.”
Medicinal Mushrooms (PDQ®)
“Medicinal mushrooms have been used for hundreds of years, mainly in Asian countries, for treatment of infections. More recently, they have also been used in the treatment of pulmonary diseases and cancer. Medicinal mushrooms have been approved adjuncts to standard cancer treatments in Japan and China for more than 30 years and have an extensive clinical history of safe use as single agents or combined with radiation therapy or chemotherapy.More than 100 species of medicinal mushrooms are used in Asia. Some of the more commonly used species include Ganoderma lucidum (reishi), Trametes versicolor or Coriolus versicolor (turkey tail), Lentinus edodes (shiitake), and Grifola frondosa (maitake).Studies have examined the effects of mushrooms on immune response pathways and on direct antitumor mechanisms. The immune effects are mediated through the mushrooms stimulation of innate immune cells, such as monocytes, natural killer cells, and dendritic cells. The activity is generally considered to be caused by the presence of high-molecular-weight polysaccharides in the mushrooms, although other constituents may also be involved. Clinical trials in cancer patients have demonstrated that G. lucidum products are generally well tolerated.[1]Many of the medical and scientific terms used in this summary are hypertext linked (at first use in each section) to the NCI Dictionary of Cancer Terms, which is oriented toward nonexperts.”
Medicinal Mushrooms (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf
The cyanthin diterpenoid and sest… preview & related info | Mendeley
“Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer’s disease (AD)-related pathologies.”
Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides
“Abstract
Three new natural products, corallocins A–C (1–3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.”
Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds
Abstract
“The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits. To stimulate broader interest in the reported beneficial properties, this overview surveys and consolidates the widely scattered literature on the chemistry (isolation and structural characterization) of polysaccharides and secondary metabolites such as erinacines, hericerins, hericenones, resorcinols, steroids, mono- and diterpenes, and volatile aroma compounds, nutritional composition, food and industrial uses, and exceptional nutritional and health-promoting aspects of H. erinaceus. The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression. The described anti-inflammatory, antioxidative, and immunostimulating properties in cells, animals, and humans seem to be responsible for the multiple health-promoting properties. A wide range of research advances and techniques are described and evaluated. The collated information and suggestion for further research might facilitate and guide further studies to optimize the use of the whole mushrooms and about 70 characterized actual and potential bioactive secondary metabolites to help prevent or treat human chronic, cognitive, and neurological diseases.”
Lions Mane, hype or helpful?
I know this is a reddit link however, it’s one of the best written reddit posts I’ve read with sources and citations and does a decent job as summarising what we know about Lions Mane mushroom.
A Common Sense Guide to Lion’s Mane (Hericium erinaceus)
by inNootropics
Manuka Honey: Medicinal Uses, Benefits, and Side Effects
https://www.webmd.com/a-to-z-guides/manuka-honey-medicinal-uses?fbclid=IwAR1paRaqHGTU8nV6INy88UwzFq-qHfi0MAj2CKlixj0GjZfrzy-vSH9AvAA#1
Fungi – Garden Culture Magazine
https://gardenculturemagazine.com/magazine/usa-canada-issue-27/?utm_source=facebook&utm_medium=GardenCulture&utm_campaign=New+Magazine+US27
Lion’s Mane mushroom – a superfood for the nervous system? – Wellspring Blog – Endeavour College of Natural Health
Anyone initiated into the world of health and cooking will know that the array of culinary delights available in the form of edible mushrooms is vast, yet what is known of the medicinal qualities of these seemingly innocuous damp-dwelling organisms?
Grow Kits & Mushroom Supplies – Urban Spore Australia
Oyster Mushrooms, Lion’s Mane, Reishi and More | Grain Spawn | Mushroom Grow Kits | Complete Guide To Growing Gourmet Mushrooms At Home | Free Shipping | South East Queensland, Australia
Source: Grow Kits & Mushroom Supplies – Urban Spore Australia
MyCommunity® Capsules — Fungi Perfecti
Benefits A blend of 17 potent mushroom species The most comprehensive immune support formula in the Host Defense line* Encourages resistance to cellular assaults* Unique combination of mushroom mycelium and fruitbodies, providing a diverse range of constituents to help balance the immune system* *These statements have
Paul Stamets – Home
Paul Stamets, Olympia, WA. 100,387 likes · 6,704 talking about this. We offer information to raise myco-awareness directly connected to Paul.
Source: Paul Stamets – Home
Mushroom Index
Mushroom Index Here is a complete listing of medicinal mushroom species featured in these web pages. So far, there are 152 species from both the ascomycota and the basidiomycota. Name Agaricus xanthodermus Agrocybe paludosa Albatrellus ovinus Alloclavaria purpurea Ampulloclitocybe clavipes Antrodia xantha Astraeus hygrometricus Bolbitius variicolor Boletopsis leucomelaena Boletus badius Boletus queletii Calocera viscosa Calocybe … Mushroom IndexRead More »
Source: Mushroom Index