Category: The ScienceScience and medical journal publications or articles and videos of reputable people using cited sources.
We search and collate these for you into a more digestible form in simply described categories.
If you wish to read more simplified or interpreted information, check our articles out in the Resources menu.
Science and medical journal publications or articles and videos of reputable people using cited sources.
We search and collate these for you into a more digestible form in simply described categories.
If you wish to read more simplified or interpreted information, check our articles out in the Resources menu.
Grow Kits & Mushroom Supplies – Urban Spore Australia
Oyster Mushrooms, Lion’s Mane, Reishi and More | Grain Spawn | Mushroom Grow Kits | Complete Guide To Growing Gourmet Mushrooms At Home | Free Shipping | South East Queensland, Australia
Source: Grow Kits & Mushroom Supplies – Urban Spore Australia
MyCommunity® Capsules — Fungi Perfecti
Benefits A blend of 17 potent mushroom species The most comprehensive immune support formula in the Host Defense line* Encourages resistance to cellular assaults* Unique combination of mushroom mycelium and fruitbodies, providing a diverse range of constituents to help balance the immune system* *These statements have
Paul Stamets – Home
Paul Stamets, Olympia, WA. 100,387 likes · 6,704 talking about this. We offer information to raise myco-awareness directly connected to Paul.
Source: Paul Stamets – Home
Mushroom Index
Mushroom Index Here is a complete listing of medicinal mushroom species featured in these web pages. So far, there are 152 species from both the ascomycota and the basidiomycota. Name Agaricus xanthodermus Agrocybe paludosa Albatrellus ovinus Alloclavaria purpurea Ampulloclitocybe clavipes Antrodia xantha Astraeus hygrometricus Bolbitius variicolor Boletopsis leucomelaena Boletus badius Boletus queletii Calocera viscosa Calocybe … Mushroom IndexRead More »
Source: Mushroom Index
How magic mushrooms induce a dreamlike state | New Scientist
A psychedelic trip on mushrooms is a surreal, dream-like experience because it triggers the brain changes that are also experienced when someone is dreaming
Source: How magic mushrooms induce a dreamlike state | New Scientist
Denver just voted to decriminalize magic mushrooms – Vox
The city’s voters approved a psilocybin mushroom decriminalization initiative.
Source: Denver just voted to decriminalize magic mushrooms – Vox
A systematic study of microdosing psychedelics
The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances yet claim a range of long-term general health and wellbeing benefits. There have been no published empirical studies of microdosing and the current legal and bureaucratic climate makes direct empirical investigation of the effects of psychedelics difficult. In Study One we conducted a systematic, observational investigation of individuals who microdose. We tracked the experiences of 98 microdosing participants, who provided daily ratings of psychological functioning over a six week period. 63 of these additionally completed a battery of psychometric measures tapping mood, attention, wellbeing, mystical experiences, personality, creativity, and sense of agency, at baseline and at completion of the study. Analyses of daily ratings revealed a general increase in reported psychological functioning across all measures on dosing days but limited evidence of residual effects on following days. Analyses of pre and post study measures revealed reductions in reported levels of depression and stress; lower levels of distractibility; increased absorption; and increased neuroticism. To better understand these findings, in Study Two we investigated pre-existing beliefs and expectations about the effects of microdosing in a sample of 263 naïve and experienced microdosers, so as to gauge expectancy bias. All participants believed that microdosing would have large and wide-ranging benefits in contrast to the limited outcomes reported by actual microdosers. Notably, the effects believed most likely to change were unrelated to the observed pattern of reported outcomes. The current results suggest that dose controlled empirical research on the impacts of microdosing on mental health and attentional capabilities are needed.
Acute subjective and behavioral effects of microdoses of LSD in healthy human volunteers – Biological Psychiatry
Numerous anecdotal reports suggest that repeated use of very low doses of lysergicacid diethylamide (LSD), known as “microdosing,†improves mood and cognitive function.These effects are consistent both with the known actions of LSD on serotonin receptors,and with limited evidence that higher doses of LSD (100-200 μg) positively bias emotionprocessing. Yet, the effects of such sub-threshold doses of LSD have not been testedin a controlled laboratory setting. As a first step, we examined the effects of singlevery low doses of LSD (0 – 26μg) on mood and behavior in healthy volunteers underdouble-blind conditions.
Why psychedelics like magic mushrooms kill the ego and fundamentally transform the brain
One of the leading disabilities afflicting people around the world today is depression. Depression has crippled millions around the world, and no drug has proven to be the conclusive answer to cure it. For Estalyn Walcoff from New York, her depression was the result of a cancer diagnosis: after receiving her cancer diagnosis, Walcoff fell […] More
Source: Why psychedelics like magic mushrooms kill the ego and fundamentally transform the brain
Mind menders: how psychedelic drugs rebuild broken brains | New Scientist
The healing powers of illegal drugs like MDMA and psilocybin are finally living up to the hype – and they are already transforming our view of mental illness
Source: Mind menders: how psychedelic drugs rebuild broken brains | New Scientist
Natural “Fasting” Molecule Exerts Anti-Aging Effects to Protect Vascular System | Nutrition Review
A molecule produced by the body during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to bloo…
Source: Natural “Fasting” Molecule Exerts Anti-Aging Effects to Protect Vascular System | Nutrition Review
Episode 148 – Scary Dairy — ATP Science USA
In today’s Episode of the ATP Project, Matt and Steve host an insight on dairy and its benefits and the outweighing concerns in regards to gut health, IGF1 and new findings in the role of Pathogenesis. They also answer some excellent FAQ’s from international listeners and possible interactions of the products. As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only – please discuss any information in this podcast with your health care professional before making any changes to your current lifestyle.
Episode 163 – Sugar Hypocrisy – Part 2 — ATP Science USA
In today’s podcast Matt and Steve talk about the sugar hypocrisy. This is part two of a two-part series. This week we discuss issues with the food pyramid and how we got to this point as well as some published evidence of corruption in the sugar industry. As always, this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only, please consult with your health care professional before making any changes to your current lifestyle.
Source: Episode 163 – Sugar Hypocrisy – Part 2 — ATP Science USA
Episode 163 – Sugar Hypocrisy – Part 1 — ATP Science USA
In today’s podcast Matt and Steve talk about the sugar hypocrisy. This is part one of a two-part series. This week we debate the sugar tax, review expert opinions and some not so expert opinions. As always, this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only, please consult with your health care professional before making any changes to your current lifestyle.
Source: Episode 163 – Sugar Hypocrisy – Part 1 — ATP Science USA
Episode 134 – Sweetener Review — ATP Science USA
Welcome to the ATP Project Episode 134 Sweetener Review. In today’s podcast Steve, Matt and Jeff review sweeteners; Sugar,Stevia, surculose, ACE-K, Zylitol, maltitol – infact the most commonly used natural and artificial sweeteners used in diet drinks, pre-workouts, protein powders and bars. The good the bad and the supervising ugly side of the industry is laid bare for you to understand what you are taking is doing to your body. As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposed only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle.
Episode 144 – Sugar Sugar — ATP Science USA
In todays Podcast Matt, Steve and Jeff discuss Sugar and its impact on the nerves, the gut and specifically how it affects Children. We also talk about why fructose from fruit and fructose from corn syrup are so vastly different and a whole lot more. As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle.
NutriBlast® Greens+ Nutrition Powder
Nutrition/Protein Powder
This is a powder that I’ve found and have been taking for some months now. It is full of amazing ingredients including Lions Mane and other mushrooms.
It’s Not Just Salt, Sugar, Fat: Study Finds Ultra-Processed Foods Drive Weight Gain : The Salt : NPR
“Landmark” study finds a highly processed diet spurred people to overeat compared with an unprocessed diet, about 500 extra calories a day. That suggests something about processing itself is at play.
Source: It’s Not Just Salt, Sugar, Fat: Study Finds Ultra-Processed Foods Drive Weight Gain : The Salt : NPR
Red and White Meats Are Equally Bad for Cholesterol | UC San Francisco
Consuming high levels of red meat or white poultry resulted in higher blood cholesterol levels than consuming a comparable amount of plant proteins.
Source: Red and White Meats Are Equally Bad for Cholesterol | UC San Francisco
Episode 116 – Intermittent Fasting — ATP Science USA
Episode – 116 Intermittent fasting In today’s podcast Steve and Jeff discuss various methods of fasting, calorie restricted diets and their impact on your health, body fat and muscle mass and whether the benefits outweigh the negatives for you. They also answer FAQ’s on Stubborn fat deposits from medications, Connective tissue disease, best online resources to learn about natural medicine, Infrared saunas and a bikini competitors weight rebound issues. As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle.
Source: Episode 116 – Intermittent Fasting — ATP Science USA
Common food additive found to effect gut microbiota – The University of Sydney
Experts call for better regulation of a common additive in foods and medicine, as research reveals it can impact the gut microbiota and contribute to inflammation in the colon, which could trigger diseases such as inflammatory bowel diseases and colorectal cancer.
Source: Common food additive found to effect gut microbiota – The University of Sydney
Healthy fat hidden in dirt may fend off anxiety disorders – Neuroscience News
10(Z)-hexadecenoic acid, a fatty acid found in the soil based bacterium Mycobacterium vaccae, interacts with immune cells to inhibit pathways that drive inflammation and increases resilience to stress. Researchers say the findings could bring us one step closer to developing a microbe-based “stress vaccine”.
Source: Healthy fat hidden in dirt may fend off anxiety disorders – Neuroscience News
Firmicutes vs Bacteroides — ATP Science USA
Introduction: If there was an infamous superhero which could punch fat right in the face it…
Episode 131 – Microbiome – Firmicutes Make you Fat! — ATP Science USA
In today’s podcast Steve, Matt and Jeff discuss the microbiome and the role the gut plays in relation to the hormones oestrogen and testosterone and how the oddly named organism firmacutes that live in your gut, do anything but make you Firm and Cute. They also answer FAQs on Detoxing after taking antibiotics, Fat loss plateau and nodular acne. As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposed only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle.
Source: Episode 131 – Microbiome – Firmicutes Make you Fat! — ATP Science USA
Anxiety Might Be Alleviated by Regulating Gut Bacteria | Technology Networks
Review of studies suggests a potentially useful link between gut bacteria and mental disorders.
Source: Anxiety Might Be Alleviated by Regulating Gut Bacteria | Technology Networks
Gut : Giulia Enders : 9781771641494
Gut by Giulia Enders, 9781771641494, available at Book Depository with free delivery worldwide.
The Integrative Human Microbiome Project | Nature
Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.
Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer
In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), and their effects on inflammation and cancer-related pain. The National Cancer Institute (NCI) currently recognizes medicinal C. sativa as an effective treatment for providing relief in a number of symptoms associated with cancer, including pain, loss of appetite, nausea and vomiting, and anxiety. Several studies have described CBD as a multitarget molecule, acting as an adaptogen, and as a modulator, in different ways, depending on the type and location of disequilibrium both in the brain and in the body, mainly interacting with specific receptor proteins CB1 and CB2. CBD is present in both medicinal and fibre-type C. sativa plants, but, unlike Δ9-THC, it is completely nonpsychoactive. Fibre-type C. sativa (hemp) differs from medicinal C. sativa, since it contains only few levels of Δ9-THC and high levels of CBD and related nonpsychoactive compounds. In recent years, a number of preclinical researches have been focused on the role of CBD as an anticancer molecule, suggesting CBD (and CBD-like molecules present in the hemp extract) as a possible candidate for future clinical trials. CBD has been found to possess antioxidant activity in many studies, thus suggesting a possible role in the prevention of both neurodegenerative and cardiovascular diseases. In animal models, CBD has been shown to inhibit the progression of several cancer types. Moreover, it has been found that coadministration of CBD and Δ9-THC, followed by radiation therapy, causes an increase of autophagy and apoptosis in cancer cells. In addition, CBD is able to inhibit cell proliferation and to increase apoptosis in different types of cancer models. These activities seem to involve also alternative pathways, such as the interactions with TRPV and GRP55 receptor complexes. Moreover, the finding that the acidic precursor of CBD (cannabidiolic acid, CBDA) is able to inhibit the migration of breast cancer cells and to downregulate the proto-oncogene c-fos and the cyclooxygenase-2 (COX-2) highlights the possibility that CBDA might act on a common pathway of inflammation and cancer mechanisms, which might be responsible for its anticancer activity. In the light of all these findings, in this review we explore the effects and the molecular mechanisms of CBD on inflammation and cancer processes, highlighting also the role of minor cannabinoids and noncannabinoids constituents of Δ9-THC deprived hemp.
Cannabidiol-loaded microspheres incorporated into osteoconductive scaffold enhance mesenchymal stem cell recruitment and regeneration of critical-s… – PubMed – NCBI
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:64-75. doi: 10.1016/j.msec.2019.03.070. Epub 2019 Mar 24.
Rapid isolation of acidic cannabinoids from Cannabis sativa L. using pH-zone-refining centrifugal partition chromatography. – PubMed – NCBI
J Chromatogr A. 2019 Aug 16;1599:196-202. doi: 10.1016/j.chroma.2019.04.048. Epub 2019 Apr 18.
Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. – PubMed – NCBI
J Chem Neuroanat. 2019 Jul;98:104-116. doi: 10.1016/j.jchemneu.2019.04.006. Epub 2019 Apr 27. Review
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammas… – PubMed – NCBI
J Cell Physiol. 2019 Apr 29. doi: 10.1002/jcp.28728. [Epub ahead of print]
Cannabinoid Regulation of Fear and Anxiety: an Update. – PubMed – NCBI
Curr Psychiatry Rep. 2019 Apr 27;21(6):38. doi: 10.1007/s11920-019-1026-z. Review
Source: Cannabinoid Regulation of Fear and Anxiety: an Update. – PubMed – NCBI
Group of Irish Doctors Publish Letter Outlining Health Concerns About Cannabis
The “Cannabis Risk Alliance” is less than enthused about Ireland’s progressing views on the herb.
Source: Group of Irish Doctors Publish Letter Outlining Health Concerns About Cannabis
New Study Finds Most Online CBD Products Are Mislabeled | Herb
A new study found that many cannabidiol (CBD) products sold online are labeled with the wrong amount of CBD. The researchers analyzed a total of 84 CBD products that they purchased online and found that 26% contained less CBD than the package suggested, while 43% contained more CBD than the package suggested.
Source: New Study Finds Most Online CBD Products Are Mislabeled | Herb
University of Washington Announces Study of Marijuana Use During Pregnancy
Could cannabis be the safest cure for morning sickness? UW researchers aim to find out.
Source: University of Washington Announces Study of Marijuana Use During Pregnancy
New Study Reveals Regular Consumption of Cannabis Keeps You thin, Fit, and Active – Canna Chronicle
Science is smashing all kinds of negative stigmas that were once thought about cannabis and the cannabis consumer.  Thanks to recent studies, people are re-learning everything they thought they knew about pot.  It is widely thought that “stoners†are “lazy, dumb, unproductive, unsuccessful and (my favorite) unhealthyâ€.  This couldn’t be farther from the truth and […]
The pharmacologic and clinical effects of medical cannabis. – Semantic Scholar
Cannabis, or marijuana, has been used for medicinal purposes for many years. Several types of cannabinoid medicines are available in the United States and Canada. Dronabinol (schedule III), nabilone (schedule II), and nabiximols (not U.S. Food and Drug Administration approved) are cannabis-derived pharmaceuticals. Medical cannabis or medical marijuana, a leafy plant cultivated for the production of its leaves and flowering tops, is a schedule I drug, but patients obtain it through cannabis dispensaries and statewide programs. The effect that cannabinoid compounds have on the cannabinoid receptors (CB(1) and CB(2) ) found in the brain can create varying pharmacologic responses based on formulation and patient characteristics. The cannabinoid Δ(9) -tetrahydrocannabinol has been determined to have the primary psychoactive effects; the effects of several other key cannabinoid compounds have yet to be fully elucidated. Dronabinol and nabilone are indicated for the treatment of nausea and vomiting associated with cancer chemotherapy and of anorexia associated with weight loss in patients with acquired immune deficiency syndrome. However, pain and muscle spasms are the most common reasons that medical cannabis is being recommended. Studies of medical cannabis show significant improvement in various types of pain and muscle spasticity. Reported adverse effects are typically not serious, with the most common being dizziness. Safety concerns regarding cannabis include the increased risk of developing schizophrenia with adolescent use, impairments in memory and cognition, accidental pediatric ingestions, and lack of safety packaging for medical cannabis formulations. This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.
Source: The pharmacologic and clinical effects of medical cannabis. – Semantic Scholar
New research shows medical marijuana may stop growth of cancer cells
New research from Penn State College of Medicine shows medical marijuana may stop the growth of colon cancer cells.
Source: New research shows medical marijuana may stop growth of cancer cells
CBD Resources, Links to CBD Research and Studies – Ganjly CBD
At Ganjly, we always get emails and questions as to where you can get more information on Ganjly CBD Research and Studies.
Source: CBD Resources, Links to CBD Research and Studies – Ganjly CBD
A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
Activation of Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, is an unexplored therapeutic approach for treatment of inflammatory diseases. We randomized 40 patients with moderate-to-severe psoriasis (4:1) to three escalating doses of SRT2104, a selective activator of SIRT1, or placebo. Across all SRT2104 groups, 35% of patients (p<0.0001) achieved good to excellent histological improvement based on skin biopsies taken at baseline and day 84 but was not consistently in agreement with PASI. Improvement in histology was associated with modulation of IL-17 and TNF-α signaling pathways and keratinocyte differentiation target genes. 27 subjects (69%) across all treatment groups, including placebo, experienced at least one treatment emergent adverse event. The majority of AEs were either mild or moderate. Most common were headache (8%), dizziness (8%), upper respiratory tract infection (8%), and psoriatic arthropathy (8%). Average drug exposure increased in a dose-dependent manner for escalating doses of SRT2104 and had high intra-subject variability in exposure (AUC %CV: 51–89%). Given the interesting signals of clinical activity, impact on gene expression and the generally favorable safety profile seen in this study, further investigation of SIRT1 activators for the treatment of psoriasis is warranted. Trial Registration Clinicaltrials.gov NCT01154101
What Are the Benefits of Fisetin?
A flavonoid called fisetin once again has been called out for its potential antiaging and neuroprotective properties.
Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. – PubMed – NCBI
Brain Res. 2016 Jul 15;1643:1-9. doi: 10.1016/j.brainres.2016.04.060. Epub 2016 Apr 26. Research Support, Non-U.S. Gov’t
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. – PubMed – NCBI
Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016/j.cmet.2011.08.014. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov’t
Partial reversal of skeletal muscle aging by restoration of normal NAD⺠levels. – PubMed – NCBI
Rejuvenation Res. 2014 Feb;17(1):62-9. doi: 10.1089/rej.2014.1546. Review
Source: Partial reversal of skeletal muscle aging by restoration of normal NAD⺠levels. – PubMed – NCBI
Nicotinamide mononucleotide | C11H15N2O8P – PubChem
Nicotinamide mononucleotide | C11H15N2O8P | CID 14180 – structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
What the Science Says About B3 Vitamins and Methylation – AboutNAD
If you spend enough time reading up on B3 vitamins, you’ll inevitably come across a […]
Source: What the Science Says About B3 Vitamins and Methylation – AboutNAD
What Are the Benefits of Fisetin?
A flavonoid called fisetin once again has been called out for its potential antiaging and neuroprotective properties.
Aging | Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation – Full Text
Aging | doi:10.18632/aging.101976. Steve Horvath, Ake T. Lu, Howard Cohen, Ken Raj
NAD+ Biosynthesis and Signaling in Plants: Critical Reviews in Plant Sciences: Vol 37, No 4
(2018). NAD+ Biosynthesis and Signaling in Plants. Critical Reviews in Plant Sciences: Vol. 37, No. 4, pp. 259-307.
Source: NAD+ Biosynthesis and Signaling in Plants: Critical Reviews in Plant Sciences: Vol 37, No 4