Category: eli5 – explain it like I’m five

eli5 is an internet meme meaning, explain it like I’m five. We break down the science into a more digestible format to help you develop the knowledge to dig deeper into the technical publications.

These articles are the perfect place to start if you are new to all of this.

Health Hacker Australia > Articles > eli5 - explain it like I'm five
Novel Neurodivergent treatments worth investigating

Novel Neurodivergent treatments worth investigating

Neurodivergent conditions, such as ADHD and autism, have traditionally been treated with medication and behavioral therapy. However, recent studies have shown promise in the use of novel treatments, including dietary changes, alternative therapies, and psychoactive substances, to help manage symptoms and improve overall well-being.

  1. Dietary Changes: According to recent research, a diet high in omega-3 fatty acids, such as those found in fatty fish and nuts, can help improve symptoms in individuals with ADHD and autism. Additionally, reducing processed and high-sugar foods has also been linked to improvement in symptoms.
  2. Alternative Therapies: Meditation and mindfulness practices, such as yoga and mindfulness-based stress reduction (MBSR), have been shown to help improve focus, regulate mood, and reduce symptoms of anxiety and depression in individuals with ADHD and autism.
  3. CBD and Cannabis: CBD, a compound found in cannabis, has been shown to have anti-inflammatory, anti-anxiety, and anti-depressant effects, making it a promising treatment for individuals with ADHD and autism. However, it is important to note that more research is needed to fully understand the effects of CBD and cannabis on neurodivergent conditions.
  4. Psychedelics: Psychedelic substances, such as psilocybin (found in magic mushrooms) and LSD, have been the subject of recent research exploring their potential use in treating depression, anxiety, and addiction. While the results of these studies are promising, it is important to note that the use of psychedelics is still illegal in many countries, and more research is needed to fully understand their effects and potential risks.

In conclusion, while traditional treatments for neurodivergent conditions, such as medication and behavioral therapy, remain the mainstay of treatment, the data suggests that there are several promising novel treatments that may help individuals with ADHD and autism manage their symptoms and improve their overall well-being. However, it is important to remember that every individual is unique, and what works for one person may not work for another. As such, it is important to consult with a healthcare professional to determine the best course of action for each individual.

Longevity, healthspan and aging: what you need to know

Longevity, healthspan and aging: what you need to know

As you age, it’s important to focus on maintaining your health and wellbeing. This means eating a healthy diet, getting regular exercise and ensuring you’re taking care of your mental health. But what about your physical health? What can you do to ensure you live a long, healthy life?

There are many things you can do to improve your lifespan and healthspan. Here are some of the most important:

  1. Eat a balanced diet

A balanced diet is key to good health. It’s important to include plenty of fresh fruits and vegetables in your diet, as well as whole grains, lean protein and healthy fats. Avoid processed foods and sugary drinks whenever possible.

  1. Get regular exercise

Exercise is essential for good health. It helps keep your body strong and healthy, and it can also help protect against diseases such as cancer. Aim for at least 30 minutes of exercise per day, five days per week.

  1. Take care of your mental health

Mental health is just as important as physical health. Taking care of your mental wellbeing can help protect against conditions such as anxiety and depression. Make sure you take some time for yourself each day to relax and de-stress. And if you’re experiencing any problems with your mental health, be sure to seek professional help.

  1. Stay hydrated

It’s important to stay hydrated by drinking plenty of water throughout the day. Dehydration can lead to a number of problems, including fatigue, headaches and dizziness. Drink at least eight glasses of water per day to stay hydrated.

  1. Get enough sleep

Getting enough sleep is essential for good health. Adults should aim for around eight hours of sleep each night. Poor sleep can lead to a number of problems, including fatigue, stress and anxiety.

  1. Take supplements if needed

In some cases, supplements may be necessary in order to maintain good health. Omega-3 fatty acids are a good example – many people don’t get enough omega-3s from their diet, so taking a supplement can be beneficial. Consult with your doctor before starting any new supplements, however – not all supplements are safe for everyone to take.

  1. Consider nmn therapy

nmN therapy is a novel treatment that uses neural modulation to improve cellular function and promote longevity [1]. The therapy involves injecting nmN into specific areas of the brain in order to promote cell rejuvenation [2]. so far, studies have shown that nmN therapy can improve cognitive function, increase lifespan and protect against age-related diseases [3].

8 . Consider rapamicin therapy

Rapamicin is a drug that has been shown to increase lifespan in animals [4]. It works by inhibiting the mTOR pathway, which is responsible for cell growth and aging [5]. Rapamicin has been shown to delay the onset of age-related diseases such as cancer and heart disease [6], and it may also be able to improve cognitive function [7].

9 . Consider metformin therapy

Metformin is a drug that is commonly used to treat diabetes [8]. However, research suggests that it may also have anti-aging properties [9]. One study found that metformin was able to extend the lifespan of worms by up to 50% [10]. Another study showed that metformin was able to reduce the risk of death from all causes in patients with type 2 diabetes [11] . While more research is needed on the anti-aging effects of metformin, it’s possible that this drug could play an important role in extending lifespan in humans .

What is ableism?

So what, exactly, counts as ableism?

If you don’t live with a disability yourself, you may not realize the numerous ways society pushes people with disabilities to the fringes.

As a start, it might help to unpack what “disability” means. This term might automatically bring to mind people with noticeable physical conditions.

For example:

  • A person who uses a wheelchair
  • a blind person who uses a sight stick
  • a person who has only one arm

But according to the Americans with Disabilities Act, a disability can include any physical or mental health condition or symptom that significantly affects at least one major activity of daily life.

Disabilities can affect the ability to:

  • communicate
  • stand, walk, or move from place to place
  • leave home
  • see, hear, breathe, or eat and drink
  • learn and remember information
  • handle work responsibilities
  • interact with others, including co-workers, friends, loved ones, and anyone else
  • shower, use the bathroom, or handle other basic needs

Mocking or dismissing someone with a disability might be a pretty obvious form of ableism, but ableism doesn’t always happen intentionally. Maybe you just never realized chronic illness or mental health conditions counted as disabilities.

But ableism often begins with the failure to acknowledge the different types of disabilities people can experience. You may not have any negative intentions or ill will, but unintentional ableism can still have a major impact.

Republished from https://www.healthline.com/health/what-is-ableism#identifying-it

Emotional thinking and conflicting opinions

Opinion

It seems apparent that there are essentially two ways to think, or reason if you prefer. The pragmatic, unemotional, and more objective process, and the emotionally driven, subjective and often bias process. This also seems to be something that is leveraged by certain actors throughout society.

One could postulate that people are being encouraged to think more emotionally in place of more pragmatic reasoning to perpetuate an advantageous environment to be leveraged. There doesn’t have to be some big conspiracy, it can be no more than a common preference selected by powerful people to market to consumers, and keep those quarterly profits at record growth every month.

Notwithstanding the immense benefits of a captialist market, a free and open market that anyone can be a part of and build wealth; it seems clear that it has it’s issues. Namely that the human race, once called Homo Erectus, is now a product of the market, not so much a consumer. We have shifted focus so much that we are now a new species, Homo Economicus. Yes, it’s an actual thing!

As we digress we take a look at the core ways of reasoning and some of the factors at play.

Emotional reasoning

Being almost entirely subjective, and often very biased, and for good reason; emotional thinking is driven by emotional needs. The need to avoid offence, seen as rude etc, are amongst the main reasons people use this approach to reasoning.

While emotional thinking is valuable and useful, it must be kept in check and measured against the pragmatic postulations. It is imperative for the individual to be discerning in choosing which reasoning to apply in any given situation. Remember, no matter how you or anyone feels about it, fact is fact.

Deductive vs pragmatic reasoning

Made famous by Sir Arthur Conan Doyle, the creator of Sherlock Holmes, deductive reasoning is a process of gathering evidence, past events leading to, and forming a foregone conclusion. These conclusions are typically considered immutable, and should not change or be questioned.

Pragmatic reasoning is not too dissimilar in that we use the above process, but we extend it to factor in context, external influences, and any other information that may have causation to the subject. Also, very importantly, the conclusion reached is transient. We take it as our best educated guess that can and should be challenged, especially as new information comes to light.

Holding conflicting opinions

If one can acknowledge the subjective experience and emotional influence in reaching conclusions, then one might find oneself holding multiple differing opinions based on differing requirements or scenarios.

Let us consider what I’m sure most would agree to be the most extreme of situations a human being can find oneself in, a passing of life.

Let us consider this using the above methods of reasoning:

Deductively and emotionally, we might say we know this person and care for them, or we suppose we are someone that does.

This triggers an emotion, often a slew of them; sadness, anger, disappointment, depression, grief etc. Depending on the person and the situation, one may act on the emotion and decide to take retribution.

However, the pragmatic thinker kicks in and we decide not to take retribution because of the concequences to us.

Here we see both ways of reasoning working together in balance. It serves us to think emotionally so that we can express empathy and console our loved ones through the grief. We act on emotional thinking here because it’s advantageous to us and the people we care about.

However, let’s suppose we don’t know the person that has passed. Perhaps we have a decision to make that impacts many. If we were to act on our emotions, is that useful? Do we have a bias here that may restrict us from considering the needs of others?

Consumer trends during Covid-19

Some interesting and somewhat encouraging news from the Woolworths CEO today via his email updates during Covid-19 show some interesting trends in consumer spending on food and vitamins during this time.

To quote from his email:

We are becoming healthier and more adventurous in our cooking
While the slow cooking movement continues, we’re also becoming increasingly adventurous. Ingredients such as cardamom, saffron and dried sesame seeds have doubled in sales. Roasted peppers are up 65%, Asian and hot chilli sauces are both up 40% and capers are up 35%.

We’re also well into soup season. What’s interesting this year is the explosive growth of dried soup mix packets (up 200%) as people make more warming soup at home.

It’s also interesting to see customers think about their health, with a big rise in vitamin sales, plus ground ginger and turmeric sales up 120% and sauerkraut up 76%. On a related topic, sales of cough and cold products are much lower this year compared to last year.”

This is encouraging and hopefully a sign that the general population is starting to become more interested in preparing fresh meals rather than fast food, and hopefully the rise in vitamins and other beneficial products is a sign that people are starting to see value in improving their health and eating better.

It’s pretty clear that the more fit and healthy you are and the better you eat, the less likely you are to contract Covid-19 and, less likely to have severe complication if you do. We have been keeping an eye on developments and have been hoping that the silver lining from all of this may be a new focus on health and well-being.

So please ensure you take some time out of your busy life to focus on whats really important, your life! We at Health Hacker wish all of you good health and encourage you to keep exploring and trying to improve your diet and lifestyle as much as possoble. Remember, something is better than nothing so start on somethign today!

What lifestyle changes will help me live longer and healthier?

We’ve previously spoken about how we might introduce foods and supplements to our diet to improve health span and lifespan. Here we explore activities and other therapies that show potential in living healthier and longer. We also explore things you perhaps should stop doing to improve health and longevity.

Mitochondrial support

Mitochondria are organelles, basically, little functional units within cells, much like an organ is to our body. They provide power to our cells by delivering ATP to the cells and are thought to once be free-ranging bacteria. It is thought that the break down of mitochondrial function is one of, if not the main contributor to aging.

Continue reading “What lifestyle changes will help me live longer and healthier?”

Which supplements can help me live longer and healthier?

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

Continue reading “Which supplements can help me live longer and healthier?”

Eating to live…longer and healthier.

There are two main ways to provide the nutrients and the myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to use supplements and the other is to do it via food in our diet.

Here, in the first of our three part series on direct action for longevity, we explore the foods you can incorporate into your diet to get those identified goodies that keep us healthy for longer. We will also include herbs here as food as they require little to no handling to be beneficial and can be consumed as a food. Some of this is known via human clinical trial while some may be a mix of anecdotal use or animal studies. In all cases we take a can’t hurt, might help, approach and will either call out or exclude anything showing any risk of harm.

It’s important to note that, while all care is taken, we cannot guarantee the accuracy of this information and you should consult your health care professional before making changes in your diet and lifestyle.

Continue reading “Eating to live…longer and healthier.”
Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to as the powerhouse of the cell due to a central role in energy production. However, modern-day mitochondria are recognized as key players in eukaryotic cell biology and are known to regulate crucial cellular processes, including calcium signalling, cell metabolism and cell death, to name a few. In this review, we will discuss foundational knowledge in mitochondrial biology and provide snapshots of recent advances that showcase how mitochondrial function regulates other cellular responses.

https://royalsocietypublishing.org/doi/full/10.1098/rsob.190126?utm_source=researcher-app&utm_medium=researcherad&utm_campaign=DVaughan_Promotedpaper_190126&utm_content=Paper

Mitochondria: Exploring 5 Lifestyle Habits to Benefit Cell Health

Mitochondria: Exploring 5 Lifestyle Habits to Benefit Cell Health

In each of our cells are small energy generators called mitochondria. The health of our mitochondria determines the amount of adenosine triphosphate (ATP) they can produce from the calories we eat and oxygen we consume. Without robust mitochondria, cells cannot do as much work as they’re capable of and we need them to do so we can stay healthy. To achieve higher levels of performance we must optimize our mitochondria, the powerhouse of our cells, to produce energy. Cell function isn’t always the first place biohackers and nootropics enthusiasts start because it is challenging to notice a subjective boost in our mitochondrial function. Whether we can detect enhanced mitochondria subjectively or not, the science is pretty clear that healthy mitochondria play a role in supporting all indicators of cognition, physical performance, and aging. In a series of comprehensive posts, we will introduce scientifically-backed lifestyle changes and nootropics that up-regulate your mitochondrial function. In our last post, we went over how to use light and temperature to boost mitochondria. Now let’s tackle 5 more lifestyle habits we can implement to achieve healthier mitochondria.

Mitochondria: Exploring 5 Lifestyle Habits to Benefit Cell Health

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?† | Open Biology

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?† | Open Biology

“The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and proliferation. The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour suppressor. AMPK can also be switched on by increases in intracellular Ca2+, by glucose starvation and by DNA damage via non-canonical, AMP-independent pathways. Genetic studies of the role of AMPK in mouse cancer suggest that, before disease arises, AMPK acts as a tumour suppressor that protects against cancer, with this protection being further enhanced by AMPK activators such as the biguanide phenformin. However, once cancer has occurred, AMPK switches to being a tumour promoter instead, enhancing cancer cell survival by protecting against metabolic, oxidative and genotoxic stresses. Studies of genetic changes in human cancer also suggest diverging roles for genes encoding subunit isoforms, with some being frequently amplified, while others are mutated.”

https://royalsocietypublishing.org/doi/10.1098/rsob.190099?utm_source=researcher-app&utm_medium=researcherad&utm_campaign=DVaughan_Promotedpaper_190099&utm_content=Paper

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks | Open Biology

“Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to as the powerhouse of the cell due to a central role in energy production. However, modern-day mitochondria are recognized as key players in eukaryotic cell biology and are known to regulate crucial cellular processes, including calcium signalling, cell metabolism and cell death, to name a few. In this review, we will discuss foundational knowledge in mitochondrial biology and provide snapshots of recent advances that showcase how mitochondrial function regulates other cellular responses.”

https://royalsocietypublishing.org/doi/full/10.1098/rsob.190126?utm_source=researcher-app&utm_medium=researcherad&utm_campaign=DVaughan_Promotedpaper_190126&utm_content=Paper

What is a stack and whats in one? – Opinion

What is a stack and whats in one? – Opinion

So you have a bunch of information on things that can help you live healthier and longer. What next?

Typically what a biohacker does is builds a stack. A stack is a collection of supplements that is aimed at a certain goal.

I’m going to give you some insight into my “pet rabbit” stack 😉 My rabbit is 104kgs and around 40 years old (Super Rabbit 😉 My rabbit is wanting to live healthier and longer as well as improve cognetive function and avoid cognitive decline. She wants to grow her hair and keep it a healthy colour and improve general health and fitness.

Firstly a dosing routine showing morning and evening dosing and which to take at what time of day for the desirable outcome.

Continue reading “What is a stack and whats in one? – Opinion”