Tag: longevity
Get-Answers Service – Oliver Zolman
Deep Dyve Service
Get answers to any health question, in more detail than your clinicians or Dr Google can provide.
https://www.droliverzolman.com/get-answers-service
This is a paid service but not a paid referral.
Increase health benefits of exercise by working out before breakfast — ScienceDaily
According to a new study, published in the Journal of Clinical Endocrinology and Metabolism, health scientists at the Universities of Bath and Birmingham found that by changing the timing of when you eat and exercise, people can better control their blood sugar levels. The six-week study, which involved thirty men classified as obese or overweight and compared results from two intervention groups (who ate breakfast before / after exercise) and a control group (who made no lifestyle changes), found that people who performed exercise before breakfast burned double the amount of fat than the group who exercised after breakfast.
Increase health benefits of exercise by working out before breakfast — ScienceDaily
Limiting mealtimes may increase your motivation for exercise — ScienceDaily
Limiting access to food in mice increases levels of the hormone, ghrelin, which may also increase motivation to exercise, according to a study published in the Journal of Endocrinology. The study suggests that a surge in levels of appetite-promoting hormone, ghrelin, after a period of fasting prompted mice to initiate voluntary exercise. These novel findings indicate that better diet control, for example limiting food intake to mealtimes or fasting intermittently, could help overweight people maintain a more effective exercise routine, lose weight and avoid debilitating complications such as diabetes and heart disease.
https://www.sciencedaily.com/releases/2019/10/191019154000.htm
3 Drug Combination Increases Lifespan | | LEAF
We show that the mitogen-activated protein kinase kinase (MEK) inhibitor trametinib, the mTOR complex 1 (mTORC1) inhibitor rapamycin, and the glycogen synthase kinase-3 (GSK-3) inhibitor lithium act additively to increase longevity in Drosophila
https://www.leafscience.org/a-triple-drug-combination-increases-lifespan/
Exploring the effect of fasting on age-related diseases — ScienceDaily
To uncover more CRMs, Kroemer and his team now tested 200 compounds that belong to the same class of substances as spermidine and resveratrol. They first examined which of these substances show cellular reactions characteristic of elevated autophagy in rat and human cell cultures, while not being toxic to the cells. An agent called 3,4-dimethoxy chalcone (3,4-DC) stood out as the best candidate. A closer look at the exact mode of action of 3,4-DC revealed that it induces autophagy through a different pathway than spermidine and resveratrol.
https://www.sciencedaily.com/releases/2019/10/191021111842.htm
Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily
Scientists at UC San Francisco and Harvard University have shown for the first time that cooking food fundamentally alters the microbiomes of both mice and humans, a finding with implications both for optimizing our microbial health and for understanding how cooking may have altered the evolution of the our microbiomes during human prehistory.
Cooking food alters the microbiome: Raw vs. cooked diets have distinct effects on both mouse and human gut microbes — ScienceDaily
You don’t have to go cold turkey on red meat to see health benefits — ScienceDaily
A new study has found that halving the amount red and processed (RPM) meat in the diet can have a significant impact on health, reducing the amount of LDL ‘bad’ cholesterol in the blood which cuts the risk of developing heart disease. Red and processed meat (RPM) include fresh pork, beef, lamb and veal and meats that have been smoked, cured or preserved (other than freezing) in some way. These meats are typically high in saturated fatty acids which cause an increase in LDL cholesterol. This is the “bad” cholesterol that collects in the walls of blood vessels, where it can cause blockages and raise the chance of a heart attack. Increasing awareness of the risks associated with eating red and processed meat has led to a growing number of people adopting vegetarian and vegan diets, which cut out meat completely. Researchers at the University of Nottingham wanted to find out if reducing the amount of red meat eaten, rather than cutting it out completely, would have a positive effect on the health of the subjects taking part.
You don’t have to go cold turkey on red meat to see health benefits — ScienceDaily
Type 2 diabetes remission possible with ‘achievable’ weight loss — ScienceDaily
People who achieve weight loss of 10% or more in the first five years following diagnosis with type 2 diabetes have the greatest chance of seeing their disease go into remission, according to a study led by the University of Cambridge.
Type 2 diabetes remission possible with ‘achievable’ weight loss — ScienceDaily
The Gut Microbiome Affects Muscle Strength in Older Adults | | LEAF
A role for the gut microbiome on the health and functioning of many tissues, including the brain, liver, kidney, and adiposity, has been widely reported in the literature. Interestingly, 2019 might be the year that the role of the gut microbiome on skeletal muscle (i.e. the gut-muscle axis) comes into greater focus. The influence of the gut microbiome on muscle strength In April, Nay et al. reported that endurance exercise capacity was reduced in mice that do not contain a microbiome (germ-free mice, GFM) when compared with conventionally raised, microbiome-containing mice. This finding suggests that there are microbes in the gut that positively influence aerobic exercise performance.
The Gut Microbiome Affects Muscle Strength in Older Adults | | LEAF
Fragmented physical activity linked to greater mortality risk — ScienceDaily
Although reduced physical activity during the day is widely seen as a harbinger of mortality in older people, fragmentation of physical activity — spreading daily activity across more episodes of brief activity — may be an earlier indicator of mortality risk than total amount of daily activity, according to a new study from scientists at the Johns Hopkins Bloomberg School of Public Health.
Fragmented physical activity linked to greater mortality risk — ScienceDaily
A brain protein that could put the brakes on Alzheimer’s — ScienceDaily
University of California, Irvine biologists blazing new approaches to studying Alzheimer’s have made a major finding on combating inflammation linked to the disease. The School of Biological Sciences researchers’ discovery about the role of a protein called TOM-1 heralds a shift toward examining the molecular underpinnings of Alzheimer’s processes. Their paper has just been published in Proceedings of the National Academy of Sciences.
A brain protein that could put the brakes on Alzheimer’s — ScienceDaily
The Life Extension Blog: Let’s Talk about Gut Health and Probiotics with Marisa Moore, RDN
Growing research suggests that gut health goes well beyond good digestion.2 It may have an impact on the immune system and mood.3-5 Research on gut bacteria continues to grow and may be a key factor in understanding and maintaining gut health.
The Life Extension Blog: Let’s Talk about Gut Health and Probiotics with Marisa Moore, RDN
High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily
Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content.
High-fructose and high-fat diet damages liver mitochondria: Increases fatty-liver disease risk and metabolic syndrome — ScienceDaily
Metabolic discovery may help in fight against heart disease, diabetes
Researchers at Cornell University have uncovered a key step in how the human body metabolizes sugar, which could lead to better treatment and prevention of heart disease, obesity and Type 2 diabetes.
Metabolic discovery may help in fight against heart disease, diabetes
Fathers-to-be should avoid alcohol six months before conception: Parental alcohol consumption linked to raised risk of congenital heart disease — ScienceDaily
Aspiring parents should both avoid drinking alcohol prior to conception to protect against congenital heart defects, according to research published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
Fathers-to-be should avoid alcohol six months before conception: Parental alcohol consumption linked to raised risk of congenital heart disease — ScienceDaily
No need to cut down red and processed meat for health reasons, controversial findings suggest — ScienceDaily
Most people can continue to eat red and processed meat as they do now. A major study led by researchers at McMaster and Dalhousie universities has found cutting back has little impact on health. A panel of international scientists systematically reviewed the evidence and have recommended that most adults should continue to eat their current levels of red and processed meat. The researchers performed four systematic reviews focused on randomized controlled trials and observational studies looking at the impact of red meat and processed meat consumption on cardiometabolic and cancer outcomes. In one review of 12 trials with 54,000 people, the researchers did not find statistically significant or an important association between meat consumption and the risk of heart disease, diabetes or cancer.
No need to cut down red and processed meat for health reasons, controversial findings suggest — ScienceDaily
Fruit flies live longer with combination drug treatment — ScienceDaily
A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study led by UCL and the Max Planck Institute for Biology of Ageing.
https://www.sciencedaily.com/releases/2019/09/190930161857.htm
Lifespan book, your quintessential guide to the science of aging and age related disease
Dr. David Sinclair’s book is truly an amazing resource that lays out the science behind why and how we age and how we can improve our health span and maybe even increase our lifespan.
The audio version on Audible is especially good with additional commentary and updates that didn’t make it to print.
The book is very affordable and there are things you could be doing right now to improve your health span and avoid or even eliminate disease.
https://lifespanbook.com?rh_ref=74f8f88c
Alpha-ketoglutarate lifespan extension
” The decline in early life mortality since the 1950s has resulted in dramatic demographic shift towards aged population. Aging manifests as a decline in health, multiple organ dysfunction and increased vulnerability to diseases, which degrades quality of life. A verity of genetic and pharmacological interventions, mostly from non-vertebrate models, have been identified that can enhance lifespan. Whether these interventions extend healthspan, the disease free and functional period of life, has only sometimes been tested and is often a matter of debate. Human aging indices have been developed to assess elements of functional decline with aging (e.g. sarcopenia, cognitive function). However, corresponding comprehensive indices in mice are seldom applied to aging studies. To probe the relationship between healthspan and lifespan extension in mammals, we performed a series of longitudinal, clinically-relevant healthspan measurements. Metabolism and aging are tightly connected and specific perturbations of nutrient-sensing pathways can enhance longevity in laboratory animals. Here we show that alpha-ketoglutarate (delivered in the form of a Calcium salt, CaAKG), a key metabolite in tricarboxylic (TCA) cycle that is reported to extend lifespan in worms, can significantly extend lifespan and healthspan in mice. AKG is involved in various fundamental processes including collagen synthesis and epigenetic changes. Due to its broad roles in multiple biological processes, AKG has been a subject of interest for researchers in various fields. AKG also influences several age-related processes, including stem cell proliferation and osteoporosis. To determine its role in mammalian aging, we administered CaAKG in 18 months old mice and determined its effect on the onset of frailty and survival, discovering that the metabolite promotes longer, healthier life associated with a decrease in levels of inflammatory factors. Interestingly the reduction in frailty was more dramatic than the increase in lifespan, leading us to propose that CaAKG compresses morbidity. “
https://www.biorxiv.org/content/10.1101/779157v1
https://www.ncbi.nlm.nih.gov/pubmed/24828042?fbclid=IwAR1a8Z8sHjZ_W8o2-z74et4afbGkO3xf5JqWzfGL2XCeFR1IyDdNaiIZsBQ
Which companies are working on longevity?
http://agingbiotech.info/companies/
AMPK Activator: A Complete Guide to AMP-activated protein kinase
“AMPK is an enzyme essential for maintaining energy balance. It consists of 3 proteins (called sub-units) that together create a functional enzyme. AMPK is expressed in various tissues, including the brain, liver, skeletal muscle, and fat cells. The net effects of AMPK activation include ketogenesis, stimulation of hepatic fatty acid oxidation, inhibition of cholesterol synthesis, triglyceride synthesis, and lipogenesis, and the stimulation of glucose uptake and skeletal muscle fatty acid oxidation.
AMPK is also an energy sensor. When activated in the proper tissues, it brings about a number of beneficial effects in the body. It improves insulin sensitivity, stimulates weight loss, enhances muscle performance, and reduces inflammation, among many other benefits. It also fosters healthy aging and is involved in multiple longevity pathways.”
AMPK Activator: A Complete Guide to AMP-activated protein kinase
RAPAMYCIN Analogue found with minimal side effects
a study published by the University of Wisconsin in July, 2019, scientists discovered that a rapamycin analog called DL001 inhibits mTOR without all the severe side effects, such as suppression of the immune system, glucose, or liver toxicity. Suppression of mTOR has been associated with better health and longer life. mTOR is activated by eating foods like red meat, so finding a way to suppress mTOR without all the harmful side effects would be a major breakthrough.
Scientists have known that mTOR is composed of two complexes, called mTORC1 and mTORC2. As it turns out, you only need to suppress one of them, mTORC1 to get all the positive longevity benefits associated with rapamycin. Suppressing mTORC2 is what has caused many of the negative side effects of rapamycin, so discovering that the rapamycin analog DL001 suppresses mTORC1 without suppressing mTORC2 is the breakthrough that may finally allow us to get the benefits of rapamycin without the severe side effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642166/
Vaping is not dangerous, black market cartridges with hydrogen cyanide is though! – Opinion
While hysteria reins on news outlets and social media and some officials calling for or enacting laws to ban it, the real source of danger is the unregulated black market cartridges that contain some chemicals that turn to hydrogen cyanide when heated.
Saying vaping is dangerous is the same as saying water is dangerous. If misused or abuse anything can be dangerous.
This blog is trying to deliver the real truth without influences from politics or even laws. We want you to have the right information so you can make truly informed choices about your health.
It is estimated that vaping is 90% more safe than smoking. Most vape products contain less chemicals and less harmful chemicals. While it’s true we don’t know long term effects, it’s pretty safe to say that it’s a better way of consumption than burning and smoking material.
Simplified Methylation Treatment Plan for Chronic Fatigue Syndrome (CFS) by Rich Van Konynenburg, Ph.D. – Health Rising
Although talking about chronic fatigue syndrome, it’s important to know about methylation especially if you’re supplementing with b group vitamins
MIB-626, the NAD+ precursor that’s superior to NMN
MIB-626 is a NAD+ precursor being developed with the help of David Sinclair’s lab. It is understood that this is the molecule that is touted to be even more effective than NMN and caused mice to run over 3km and break the lab treadmill.
It’s not yet available but one to really keep an eye on.
Watch “This Harvard Professor Explains the Secret to Aging in Reverse | David Sinclair on Health Theory” on YouTube
A very good interview with David Sinclair to explain the systems involved and how we can possibly manipulate them to increase health and lifespan
Despite growing burden of diet-related disease, medical education does not equip students to provide high quality nutritional care to patients: Researchers call for improved nutrition education to be integrated into the medical curriculum — ScienceDaily
This is why you don’t ask your doctor about nutrition and, why they very likely won’t know about anything on this blog.
https://www.sciencedaily.com/releases/2019/09/190918184454.htm
Suicide prevention | R U OK?
Today is national R U OK day. One of the big objectives of sharing this information on this blog is to help people be healthier and live longer, happier lives.
Don’t be afraid to ask your friends and family if they are OK and don’t be afraid to listen.
You don’t have to know the answers or even what to say back, just listen. Be there for your loved ones to vent and vocalise internal thoughts.
What are some things that can help with depression and anxiety?
Bananas are high in tryptophan, this is a seratonin support amino-acid as well as for melatonin.
Vitamin B3 or nicotonimide has also been shown to help with depression and anxiety.
On top of that, a healthy diet and keeping active are also helpful.
Take care and be kind to one another.
Vegans Should Consider Taking DHA Supplements | NutritionFacts.org
“A “double-blind randomized interventional study provide[d] first-time evidence that [extra long-chain omega-3s] exert positive effects on brain functions in healthy older adults,†a significant improvement in executive function after six and a half months of supplementation, and significantly less brain shrinkage compared to placebo.”
https://nutritionfacts.org/2019/08/27/vegans-should-consider-taking-dha-supplements/
Food, Inc.
This is a little old now but still a very pertinent documentary.
Declines in mental health associated with air pollution and temperature variability in China | Nature Communications
Opinion: I’ve always said that I’d rathwr do things to improve our environment and be wrong about climate change than to do the opposite. The potential risks are great but also the potential benefits to cleaning up our act could also be great. Here we have a paper showing causality between mental health decline and pollution levels.
Fisetin is a senotherapeutic that extends health and lifespan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/
Can Anti-Aging Research Keep Us Healthy in the Long Run?
Searching for the fountain of eternal youth has been the dream of humanity for millennia. While this is still in the realms of science fiction, anti-aging companies are hoping to tackle aging-related diseases by targeting the underlying biology.
The elusive NMN transporter is found | Nature Metabolism
https://www.nature.com/articles/s42255-018-0015-6.epdf?author_access_token=tIjJpYvdIE2gwCBGU5exo9RgN0jAjWel9jnR3ZoTv0PSwgIdarKxTsHvskOSeGnKNKpJ60gjlqtZgH4n03zYoKlfT87k9r3DYjJk1bPsmJ720PtxwK6yfL_w67qTHStYds8YdtMpXwOXBda2-VRq8A%3D%3D
Lifespan – book
Dr. David Sinclair has somehow found the time to write up all his information on how we age and some of the methods and molecules they are testing now to help us age more gracefully and maybe even extend lifespan.
His book launches soon and is available for pre-order now.
Diet and exercise research secures $1.77 million | Swinburne news
If there’s one thing lacking in the diet and nutrition space it’s real correlated science and clinic studies.
Much of what doctors say to you regarding salt and fats and heart disease is anecdotal observation.
The only real data we have is on high sugar diets. Well, now we have a study funded to look into this deeper.
Keep en eye on this one.
Sugar industry exploited dietitians to influence dentists, study shows
SAN FRANCISCO, U.S./VANCOUVER, British Columbia, Canada: In 1975, the U.S. Sugar Association (SA) created the Regional Nutritional Information Program (RNIP) in an effort to enlist dietitians to spread positive messages about sugar and health. A recent study has inquired into the RNIP and evaluated its impact on dental professionals. The findings suggest that the sugar industry used dietitians strategically in order to influence the dental community’s views on sugar.
https://www.dental-tribune.com/news/sugar-industry-exploited-dietitians-to-influence-dentists-study-shows/
Synergism between Medihoney and rifampicin against methicillin-resistant Staphylococcus aureus (MRSA). – PubMed – NCBI
Abstract
Skin and chronic wound infections caused by highly antibiotic resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) are an increasing and urgent health problem worldwide, particularly with sharp increases in obesity and diabetes. New Zealand manuka honey has potent broad-spectrum antimicrobial activity, has been shown to inhibit the growth of MRSA strains, and bacteria resistant to this honey have not been obtainable in the laboratory. Combinational treatment of chronic wounds with manuka honey and common antibiotics may offer a wide range of advantages including synergistic enhancement of the antibacterial activity, reduction of the effective dose of the antibiotic, and reduction of the risk of antibiotic resistance. The aim of this study was to investigate the effect of Medihoney in combination with the widely used antibiotic rifampicin on S. aureus. Using checkerboard microdilution assays, time-kill curve experiments and agar diffusion assays, we show a synergism between Medihoney and rifampicin against MRSA and clinical isolates of S. aureus. Furthermore, the Medihoney/rifampicin combination stopped the appearance of rifampicin-resistant S. aureus in vitro. Methylglyoxal (MGO), believed to be the major antibacterial compound in manuka honey, did not act synergistically with rifampicin and is therefore not the sole factor responsible for the synergistic effect of manuka honey with rifampicin. Our findings support the idea that a combination of honey and antibiotics may be an effective new antimicrobial therapy for chronic wound infections.
https://www.ncbi.nlm.nih.gov/m/pubmed/23469049/?fbclid=IwAR1w8X7OYE9RRw27zOFFO5zmevpNahNN2pZYbZIz0CoGiysH0bs-0dtZT_4