Author: Nathan
Read my blog or one of my many profiles lol

Health Hacker Australia > Articles by: Nathan
The effects of resveratrol on lipid profiles and liver enzymes

The effects of resveratrol on lipid profiles and liver enzymes

This meta-analysis demonstrated that resveratrol supplementation among patients with MetS and related disorders significantly reduced total cholesterol and increased GGT concentrations, but did not affect triglycerides, LDL-, HDL-cholesterol, ALT, and AST concentrations. This data suggests that resveratrol may have a potential cardio-protective effect in patients with MetS and related disorders

https://link.springer.com/article/10.1186/s12944-020-1198-x?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Reproductive Aging Process Reversed in Mice | Technology Networks

Reproductive Aging Process Reversed in Mice | Technology Networks

Dr. David Sinclair posted this morning on reversing the effects of aging on reproductive viability.

https://www.linkedin.com/posts/sinclairda_our-research-teams-just-published-a-promising-activity-6633781677380423680-fXys

https://www.technologynetworks.com/cell-science/news/reproductive-aging-process-reversed-in-mice-330636

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis: Cancer Cell

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis: Cancer Cell

“Why does cancer risk increase as we age? Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations, this question is a matter of ongoing debate. Here, we propose that the normal decline in oxidative metabolism during aging constitutes an early and important “hit” that drives tumorigenesis. Central to these metabolic changes are the sirtuins, a family of NAD+-dependent deacylases that have evolved as coordinators of physiological responses to nutrient intake and energetic demand. Thus, the modulation of sirtuins might be a fruitful approach to reversing the age-related metabolic changes that could underlie tumorigenesis.”

https://www.cell.com/cancer-cell/fulltext/S1535-6108(13)00534-5

Atg11 is required for initiation of glucose starvation-induced autophagy

Atg11 is required for initiation of glucose starvation-induced autophagy

“How energy deprivation induces macroautophagy/autophagy is not fully understood. Here, we show that Atg11, a receptor protein for cargo recognition in selective autophagy, is required for the initiation of glucose starvation-induced autophagy.”

https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1719724?af=R&utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Mitophagy and DNA damage signaling in human aging

Mitophagy and DNA damage signaling in human aging

Highlights

•DNA damage regulates mitophagy induction and mitochondrial homeostasis.

•Nuclear-mitochondrial signaling modulates aging and age-associated disorders.

•Combinatorial approaches targeting DNA repair and mitophagy could promote healthy aging.

Mitophagy and DNA damage signaling in human aging – ScienceDirect
Education and age-related decline in cognitive performance

Education and age-related decline in cognitive performance

Highlights

•Association of education and change in cognitive performance is negligible.

•Articles included in meta-analysis displayed high unexplained heterogeneity.

•Theories of cognitive aging need to be updated with regards to this association.

Education and age-related decline in cognitive performance: Systematic review and meta-analysis of longitudinal cohort studies – ScienceDirect
Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism – ScienceDirect

Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism – ScienceDirect

Extension of lifespan and amelioration of aging-associated phenotypes have been targets of many studies. Some of the established methods of increasing lifespan including dietary restriction and genetic manipulation are difficult to apply to humans, and their side effects are hard to predict. For that reason, it is important to discover compounds that can mimic the anti-aging actions or induce lifespan extension through different metabolisms within the cell. Here we summarize the recent studies to test various types of compounds and materials using budding yeast that show potential anti-aging effects.

Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism – ScienceDirect
SIRT6 Finding the gas pedal on a slow sirtuin

SIRT6 Finding the gas pedal on a slow sirtuin

“The class III histone deacetylase sirtuin 6 (SIRT6) modulates numerous functions in the cell by deacetylating histone lysine residues. Interestingly, SIRT6’s efficiency in in vitro experiments is far greater against substrates carrying long-chain fatty acyl modifications such as myristoylated lysine compared with acetylated counterparts, but the deacetylase activity can be stimulated by fatty acids and small-molecule allosteric modulators. A new study helps to explain this puzzling activation using a novel activator, thorough kinetic investigation, and mutagenesis studies. These data help elucidate the molecular requirements for activation of SIRT6 and provide a foundation for development of activators for therapeutic purposes.”

http://m.jbc.org/content/295/5/1400.full

Banana Lectin Offers Hope Against Deadly Flu

Banana Lectin Offers Hope Against Deadly Flu

“In a new paper published in the Proceedings of the National Academy of Sciences, researchers have shown that an engineered compound based on a banana lectin, a protein called H84T, has real potential for clinical use against influenza.”

http://sciencemission.com/site/index.php?page=news&type=view&id=microbiology-virology%2Fbanana-lectin-offers&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Mitochondria Found Independently Living in Blood | | LEAF

Mitochondria Found Independently Living in Blood | | LEAF

“The research team has published a new study, which shows that aside from the usual mitochondrial populations living inside our cells, there are also wandering mitochondria floating around in our bloodstreams. From time to time, mitochondria are found outside the cells, but only in the context of debris within platelets, so what are these intrepid mitochondria doing out there alone in the bloodstream?

https://www.leafscience.org/mitochondria-found-independently-living-in-blood/

The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence | SpringerLink

The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence | SpringerLink

“Given the growing challenges in chronic pain management coupled with the ongoing consequences of the opioid epidemic, pain management practitioners are looking into more effective, innovative, and safer alternatives to treat pain. Cannabis-based medicine had been described for hundreds of years but only recently have we seen the more scientific, evidence-based approach to its use, and ongoing investigations continue to explore its potential medical benefits. While historically more attention has been paid to the psychoactive component of the cannabis plant Δ9-tetrahydrocannabinol (THC), there have been fewer scientific studies on the medical use of the cannabidiol (CBD) – a non-psychoactive component of the cannabis plant.”

https://link.springer.com/article/10.1007/s11916-020-0835-4

Antimicrobial properties of Fomitopsis officinalis (Agarikon Mushroom) in the light of its bioactive metabolites: a review: Mycology: Vol 10, No 1

Antimicrobial properties of Fomitopsis officinalis (Agarikon Mushroom) in the light of its bioactive metabolites: a review: Mycology: Vol 10, No 1

According to several reports there is evidence of a broad-spectrum antibacterial and antiviral activity by F. officinalis, including pathogens like Mycobacterium tuberculosis, Yersinia pseudotuberculosis and Staphylococcus aureus, as well as Ortopox virus.

https://www.tandfonline.com/doi/full/10.1080/21501203.2018.1536680

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China – ScienceDirect

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China – ScienceDirect

“By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα.”

https://www.sciencedirect.com/science/article/pii/S0140673620301835

Novel coronavirus 2019 (2019 n-CoV) – Fact sheets

Novel coronavirus 2019 (2019 n-CoV) – Fact sheets

What is a coronavirus?
Coronaviruses are a large family of viruses, some cause illness in humans, and others cause illness in animals, such as bats, camels, and civets. Human coronaviruses cause mild illness, such the common cold.

Rarely, animal coronaviruses can evolve to infect and spread among humans, causing severe diseases such as Severe Acute Respiratory Syndrome (SARS) which emerged in 2002, and Middle East Respiratory Syndrome (MERS) which emerged in 2012.

A novel coronavirus (2019-nCoV) is a new strain of coronavirus that has not been previously identified in humans.

What is 2019 novel coronavirus?
There is a new coronavirus affecting people who have recently been in the city of Wuhan, China. There is much more to learn about how it is spread, its severity, and other features associated with 2019-nCoV, and investigations are ongoing. At the moment, this coronavirus is called ‘novel coronavirus 2019’ or ‘2019-nCoV’.

Outbreaks of a novel coronavirus infections among people are always a public health concern. There is growing evidence that 2019-nCoV can spread from person to person in the community and in health care settings. There have been cases of 2019-nCoV reported in several Asian and other countries including Australia. The situation is evolving rapidly.

What are the symptoms?
Most case-patients have had fever, cough, and shortness of breath, with further evidence of pneumonia (chest infection).

Further investigation is required to assess whether there are undetected asymptomatic or mildly symptomatic cases.

How is it spread?
Early reports indicated that most of the cases had prior contact with a seafood and live animal market, suggesting an animal source of the outbreak. However, more recently, human to human transmission has been reported.

Further investigation is underway to confirm and describe the mode of transmission from animal sources, and the risk of human-to-human transmission.

Human to human transmission is most likely to be through direct contact with infectious patients, by respiratory droplets and by fomites (contaminated objects and surfaces), as is seen with other coronavirus infections including SARS and MERS.

Who is at risk?
People who are living or travelling to affected areas or who have had contact with other cases may be at risk of catching the disease. People with underlying illnesses that make them more vulnerable to respiratory disease, including those with diabetes, chronic lung disease, pre-existing kidney failure, people with suppressed immune systems and the elderly may be at a higher risk.

How is it prevented?
It’s likely that general prevention measures used for other coronavirus infections will also prevent infection with 2019-nCoV.

The World Health Organization (WHO) recommends measures to reduce the general risk of acute respiratory infections while travelling in or from affected areas by:

avoiding close contact with people suffering from acute respiratory infections;
frequent hand-washing, especially after direct contact with ill people or their environment;
avoiding close contact with live or dead farm or wild animals;
travellers with symptoms of acute respiratory infection should practice cough etiquette (maintain distance, cover coughs and sneezes with disposable tissues or clothing, and wash hands).
Travellers to China are already advised not to visit live bird and animal markets, including ‘wet’ markets, due to the risk of avian influenza.

There is currently no vaccine to prevent 2019-nCoV infections.

What should I do if I become unwell after travel in China?
If you become ill or feel unwell while travelling in China, you should not wait until you arrive back in Australia to seek medical assistance. Instead you should see a doctor or go to the local emergency department.

If you return from travel to China and feel unwell you should see your doctor or go to the emergency department to work out why you are ill, and you should mention your travel to China. Call ahead and explain that you might have been exposed to the novel coronavirus so that the doctor can make arrangements to see you quickly and safely.

How is it diagnosed?
Infection with 2019-nCoV is diagnosed by finding evidence of the virus in respiratory samples such as swabs from the throat or fluid from the lungs. Testing for 2019-nCoV is done in public health laboratories.

How is it treated?
There is currently no specific treatment for people who are sick with 2019-nCoV but general supportive medical care in hospital can be life-saving.

What is the public health response?
As of 23 January 2020, in Australia procedures to prevent the local spread of 2019-nCoV have been put in place.

Public health unit staff will investigate all cases to find out how the infection occurred, identify other people at risk of infection, implement control measures and provide other advice.

Further information
World Health Organization novel coronavirus information

NSW Health novel coronavirus alerts for GPs and hospital clinicians

For further information please call your local Public Health Unit on 1300 066 055

https://www.health.nsw.gov.au/Infectious/factsheets/Pages/novel-coronavirus.aspx

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell

Highlights
• Fasting induces fatty acid oxidation (FAO) in intestinal stem and progenitor cells
• Aging reduces ISC numbers and function, correlating with decreased FAO
• PPAR/CPT1a-mediated FAO augments ISC function in aging and during regeneration
• PPARδ agonists boost and restore ISC and progenitor function in young and old age

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30163-2

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan – ScienceDirect

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan – ScienceDirect

Highlights
• The kynurenine pathway has recently been identified as a promising target to increase healthy longevity.

• Targeted inhibition of kynurenine pathway activity may alleviate several pathological conditions and promote healthspan.

• Changes to the production and recycling of NAD+ is a likely mediator of the beneficial effects of kynurenine pathway interventions.

• Mitochondrial function and dynamics represent NAD+-dependent processes downstream of kynurenine metabolism that may mediate benefits during aging.

https://www.sciencedirect.com/science/article/pii/S053155651930765X

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

“We confirm previous findings, showing age-related hypermethylation, and describe, for the first time, that this gain in methylation also occurs in human hepatocytes. Furthermore, we show that age-related hypermethylation is enhanced in livers of rat upon CR at two and 10 months, and that at two months a trend towards the reduction of rRNA expression occurs. Collectively, our results suggest that CR modulates age-related regulation of methylation at the rDNA locus, thus providing an epigenetic readout of the pro-longevity effects of CR.”

https://www.mdpi.com/2072-6643/12/2/277

Understanding oxidants and antioxidants: Classical team with new players

Understanding oxidants and antioxidants: Classical team with new players

We talk about antioxidants a lot. Much of our longevity supplements are in fact antioxidants but, what are antioxidants and what is oxidisation and, furthermore, why do we care about it?

https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13145?af=R&utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound&sid=researcher

Oncotarget | From rapalogs to anti-aging formula

Oncotarget | From rapalogs to anti-aging formula

Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18033&path%5B%5D=57761

7-Day Easy Bulletproof Cyclical Ketosis Meal Plan (with Recipes)

7-Day Easy Bulletproof Cyclical Ketosis Meal Plan (with Recipes)

In the following link you’ll find a new post from Bulletproof, of Dave Asprey fame, about a proposed keto style diet plan complete with recipes.

  • Health Hacker has no affiliation with Bulletproof and does not guarantee the content.
Deuterium-Depleted Water, Water Filtration, Alkaline Water, & Much More!

Deuterium-Depleted Water, Water Filtration, Alkaline Water, & Much More!

Water, simple H2O right? Not quite. In this podcast, Ben Greenfield speaks with Robert Slovak about different types of water and possible benefits.

https://bengreenfieldfitness.com/podcast/nutrition-podcasts/deuterium-depleted-water/

Fantastic Fungi comes to Australia! – Dendy Cinemas

The Fantastic Fungi movie looks to be the most comprehensive and up to date presentation of the world of mushrooms and we finally have dates for Australia!

from the movie synopsis :

When so many are struggling for connection, inspiration and hope, Fantastic Fungi brings us together as interconnected creators of our world.

Fantastic Fungi, directed by Louie Schwartzberg, is a consciousness-shifting film that takes us on an immersive journey through time and scale into the magical earth beneath our feet, an underground network that can heal and save our planet. Through the eyes of renowned scientists and mycologists like Paul Stamets, best-selling authors Michael Pollan, Eugenia Bone, Andrew Weil and others, we become aware of the beauty, intelligence and solutions the fungi kingdom offer us in response to some of our most pressing medical, therapeutic, and environmental challenges.

“Fantastic Fungi,” offers nothing less than a model for planetary survival.”

~ Jeannette Catsoulis,
The New York Times

“Gorgeous photography! Time-lapse sequences of mushrooms blossoming forth could pass for studies of exotic flowers growing on another planet.”

~ Joe Morgenstern,
The Wall Street Journal

“Schwartzberg’s film quickly proves to be one of the year’s most mind-blowing, soul-cleansing and yes, immensely entertaining triumphs.”

~ Matt Fagerholm,
RogerEbert.com

“A must see for anyone interested in life, death and the pursuit of the planet’s well-being.”

~ David Carpenter,
Forbes

https://www.dendy.com.au/movies/fantastic-fungi

Metformin mediates cardioprotection against aging‐induced ischemic necroptosis – Li – – Aging Cell – Wiley Online Library

Metformin mediates cardioprotection against aging‐induced ischemic necroptosis – Li – – Aging Cell – Wiley Online Library

“Notably, metformin treatment disrupted p62‐RIP1‐RIP3 complexes and effectively repressed I/R‐induced necroptosis in aged hearts, ultimately reducing mortality in this model. These findings highlight previously unknown mechanisms of aging‐related myocardial ischemic vulnerability: p62‐necrosome‐dependent necroptosis. Metformin acts as a cardioprotective agent that inhibits this unfavorable chain mechanism of aging‐related I/R susceptibility.”

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13096?utm_campaign=RESR_MRKT_Researcher_inbound&af=R&utm_medium=referral&utm_source=researcher_app

Resveralogues: From Novel Ageing Mechanisms to New Therapies? – Abstract – Gerontology – Karger Publishers

Resveralogues: From Novel Ageing Mechanisms to New Therapies? – Abstract – Gerontology – Karger Publishers

“For much of the 20th century the ageing process was thought to be the result of the interplay of many different biological processes, each with relatively small effects on organismal lifespan. However, this model is no longer tenable. Rather it seems a few biological mechanisms, including nutrient sensing, telomere attrition and cellular senescence, mediate large effects on health and longevity. Biogerontology may have suffered from initial delusions of complexity. However, we argue that it is premature to assume either that the list of biological processes influencing lifespan is now comprehensive or that these mechanisms act independently of each other.”

https://www.karger.com/Article/Abstract/504845

IJMS | Free Full-Text | BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

IJMS | Free Full-Text | BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

“B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways.”

https://www.mdpi.com/1422-0067/21/2/418?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis – ScienceDirect

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis – ScienceDirect

Highlights
• NAD+ plays an important protective role in some age-related degenerative disease states.

• NAD+ can improve mitochondrial function and maintain sufficient levels of ATP.

• NAD+ can influences DNA repair, and immune and longevity processes.

• Raising NAD+ levels can balance energy needs with supply and protect against oxidative damage and inflammation.

• Further clinical trials are necessary to validate NAD+ therapy in ageing and disease.

https://www.sciencedirect.com/science/article/pii/S0531556519307582

Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation | BMC Complementary Medicine and Therapies | Full Text

Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation | BMC Complementary Medicine and Therapies | Full Text

“These results suggest that C. militaris inhibited ovarian cancer cell proliferation, survival, and migration, possibly through the coordination between TNF-α/TNFR1 signaling and NF-κB activation. Taken together, our findings provide a new insight into a novel treatment strategy for ovarian cancer using C. militaris.”

https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2780-5

Biohacking app coming soon

Biohacking app coming soon

We have no affiliation with this company but after reading their proposition, this app looks to have potential.

From their website:

Use modern technology to become your ultimate self…

…with less effort and no guessing.

You can sign up for the waiting list below:

https://ultiself.com?reftoken=e5ac4be91d340e67286ff0a2f7d8ff98

The Healthy Grain BARLEYmaxâ„¢ and Kebari Barley

The Healthy Grain BARLEYmaxâ„¢ and Kebari Barley

Developed by CSIRO scientists, BARLEYmaxTM wholegrains represent the next evolution of superfoods, an enhanced wholegrain. The credentials of BARLEYmaxTM begin with it’s history. It was bred using traditional plant breeding processes, and is 100% GM free. The enhanced wholegrain discovered by Dr Morell and his team at the CSIRO contains two times the dietary fibre and four times the resistant starch of a regular grain.

The Healthy Grain BARLEYmaxâ„¢ and Kebari Barley
Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in Caenorhabditis elegans – Novakovic – – FEBS Letters – Wiley Online Library

Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in Caenorhabditis elegans – Novakovic – – FEBS Letters – Wiley Online Library

“Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF‐1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and show that depletion of individual zipt genes results in a decreased lifespan”

https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13725

The somatic mutation landscape of the human body | Genome Biology | Full Text

The somatic mutation landscape of the human body | Genome Biology | Full Text

“Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized.”

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1919-5

Study finds losing a night of sleep may increase blood levels of Alzheimer’s biomarker | EurekAlert! Science News

Study finds losing a night of sleep may increase blood levels of Alzheimer’s biomarker | EurekAlert! Science News

“A preliminary study by researchers at Uppsala University has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau – a biomarker for Alzheimer’s disease – in their blood than when they had a full, uninterrupted night of rest. The study is published in the medical journal Neurology.”

https://www.eurekalert.org/pub_releases/2020-01/uu-sfl010820.php

Biologists identify pathways that extend lifespan by 500%

Biologists identify pathways that extend lifespan by 500%

“Because alteration of the IIS pathways yields a 100 percent increase in lifespan and alteration of the TOR pathway yields a 30 percent increase, the double mutant would be expected to live 130 percent longer. But instead, its lifespan was amplified by 500 percent.

“Despite the discovery in C. elegans of cellular pathways that govern aging, it hasn’t been clear how these pathways interact,” said Hermann Haller, M.D., president of the MDI Biological Laboratory. “By helping to characterize these interactions, our scientists are paving the way for much-needed therapies to increase healthy lifespan for a rapidly aging population.””

https://phys.org/news/2020-01-biological-scientists-pathways-lifespan.html

Fad or Future Podcast | Hosted by Joey Thurman

Fad or Future Podcast | Hosted by Joey Thurman

“I’ve been talking about the benefits of “stressed plants” a lot of late. And that’s because of xenohormesis. I believe that when we eat plants that have been stressed, our bodies pick up on those chemical cues and allows us to get the stress benefits. That is, our own hormesis benefits. This is one of the reasons why I believe organic foods are better for us. More here from my discussion with Joey Thurman”

David A Sinclair

Full link here:

https://www.fadorfuture.com/

What lifestyle changes will help me live longer and healthier?

We’ve previously spoken about how we might introduce foods and supplements to our diet to improve health span and lifespan. Here we explore activities and other therapies that show potential in living healthier and longer. We also explore things you perhaps should stop doing to improve health and longevity.

Mitochondrial support

Mitochondria are organelles, basically, little functional units within cells, much like an organ is to our body. They provide power to our cells by delivering ATP to the cells and are thought to once be free-ranging bacteria. It is thought that the break down of mitochondrial function is one of, if not the main contributor to aging.

Continue reading “What lifestyle changes will help me live longer and healthier?”

Which supplements can help me live longer and healthier?

There are two main ways to provide the nutrients and myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to include foods and adjust your diet, however, we don’t always have that option to due various constraints such as taste and lifestyle. This is where supplements step in to provide the essential components of those foods as extracts or via chemical synthesis.

Here we explore the supplements you can incorporate into your lifestyle to get those identified goodies that keep us healthy for longer. This is the second of three articles on increasing health and life span. Our article on foods will have some overlap with this article as in many cases supplements are a derivative of food.
As always, we do our best to validate any information presented however, we cannot guarantee the accuracy of statements made here and does not constitute medical advice. Please check with your healthcare professional before making changes to your diet and lifestyle.
We have included as many references as possible to back our claims and for you to click into to investigate further for yourself. We encourage anyone seeking to improve their health via supplementation to take some time to research it’s effects, side effects and dosage.

Continue reading “Which supplements can help me live longer and healthier?”

Eating to live…longer and healthier.

There are two main ways to provide the nutrients and the myriad of compounds that can help your body operate at its best and improve both lifespan and healthspan. One is to use supplements and the other is to do it via food in our diet.

Here, in the first of our three part series on direct action for longevity, we explore the foods you can incorporate into your diet to get those identified goodies that keep us healthy for longer. We will also include herbs here as food as they require little to no handling to be beneficial and can be consumed as a food. Some of this is known via human clinical trial while some may be a mix of anecdotal use or animal studies. In all cases we take a can’t hurt, might help, approach and will either call out or exclude anything showing any risk of harm.

It’s important to note that, while all care is taken, we cannot guarantee the accuracy of this information and you should consult your health care professional before making changes in your diet and lifestyle.

Continue reading “Eating to live…longer and healthier.”
3 Ways We May Be Able To Reverse Aging, From A Microbiologist

3 Ways We May Be Able To Reverse Aging, From A Microbiologist

“Organic foods aren’t held with gloves. They’re a little bit more stressed out. The more stressed out your food is the brighter colors they’ll have because they’re producing these colors as a defense,” Sinclair explains.

Those bright colors, he adds, are indicators that the food has produced “xenohormesis molecules,” which activate our sirtuins that give our bodies an extra boost for longevity.

https://www.mindbodygreen.com/articles/3-easy-hacks-for-longevity-from-an-aging-microbiologist

Bulletproof 30-Day Sleep Challenge

Bulletproof 30-Day Sleep Challenge

Sleep better in the new year with the Bulletproof 30-Day Sleep Challenge. For the duration of the challenge, you’ll employ science-backed methods designed to help you sleep deeper, so you wake up refreshed.The Bulletproof 30-Day Sleep Challenge is laid out as a series of four steps. When implemented together, they’ll make you a champion at sleep, and as a result, a champion at life.  The Sleep Challenge will help you sleep better by focusing on sleep hygiene, stress, diet, and tracking your progress.The order you do them in doesn’t matter — as long as you see to all four components before starting, you’re golden.

Bulletproof 30-Day Sleep Challenge
Fisetin | | LEAF

Fisetin | | LEAF

“Fisetin, like many plant polyphenols, is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection. It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.

Finally, more recently, it has also shown promise as a senolytic, a compound that encourages aged or damaged senescent cells to destroy themselves rather than lingering in the body and contributing to the chronic, age-related inflammation known as “inflammaging”, which is associated with a wide range of age-related diseases.

Since fisetin has a good safety profile, Mayo Clinic followed these mouse studies by launching three trials to see if the compound is effective for humans.”

Human Clinical Trials with Fisetin:

Fisetin | | LEAF

Role of calcium channels in the development of diabetes – Science Mission

Role of calcium channels in the development of diabetes – Science Mission

http://sciencemission.com/site/index.php?page=news&type=view&id=obesity-diabetes%2Frole-of-calcium&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. – PubMed – NCBI

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. – PubMed – NCBI

“Compared to placebo, pretreatment with 300 mg of CBD significantly reduced anxiety during the speech. No significant differences in VAMS scores were observed between groups receiving CBD 150 mg, 600 mg and placebo.”

https://www.ncbi.nlm.nih.gov/pubmed/30328956

Australian Bushfire Relief: Where you can donate

Please excuse the slightly off topic post and thank you an advance for reading. We don’t like to stray from our core focus however, people’s lives and health are under threat.

As you may or may not be aware, Health Hacker is based in Sydney, Australia and our state, as well as neighbouring states have seen huge amounts of devastation over the last few months. Massive tracts of forests have been burned with countless animal losses and homes and human lives lost.

If you can help in any way but aren’t sure how, this is how:

TO HELP AFFECTED COMMUNITIES

Australian Red Cross Disaster Recovery and Relief
The Australian Red Cross is supporting communities affected by fires in NSW, QLD and SA. Volunteers are providing psychological first aid, working at evacuation centres and helping people to get in touch with their loved ones.
Where to donate: redcross.org.au/campaigns/disaster-relief-and-recovery-new-years-eve

Salvation Army Disaster Appeal
Salvation Army teams have been activated at multiple locations across the country. They are providing meals to evacuees and frontline responders, and will continue to provide whatever support is needed as the situation develops.
Where to donate: salvationarmy.org.au/donate/make-a-donation/donate-online/

St Vincent de Paul Society Bushfire Appeal
The St Vincent De Paul Society is running a NSW bushfire appeal, to help those affected with food, clothing, furniture, other essentials, and funds to pay bills.
Where to donate: donate.vinnies.org.au/appeals-nsw/vinnies-nsw-bushfire-appeal-nsw

Givit
Givit is encouraging people to donate funds or specific items requested by residents.
Where to donate: givit.worldsecuresystems.com/items-needed

Foodbank
Foodbank is delivering emergency food relief and water to firefighters and local communities caught up in the bushfires.
Where to donate: foodbank.org.au/support-us/make-a-donation/

TO HELP FIREFIGHTERS

Support firefighter families
Donate to the families of the volunteer firefighters who were tragically killed while on duty.
Where to donate: rfs.nsw.gov.au/news-and-media/general-news/featured/support-for-firefighter-families

TO HELP WILDLIFE

WIRES
WIRES is accepting donations to help their efforts in supporting displaced and injured wildlife.
Where to donate: wires.org.au/donate/emergency-fund

Koalas in Care Inc
Koalas in Care Inc are accepting donations to help koalas injured or displaced by the fires in NSW.
Where: to donate: koalasincare.org.au/pages/donation.htm

The Port Macquarie Koala Hospital
The Port Macquarie Koala Hospital is accepting donations to develop and build watering stations for thirsty koalas.
Where to donate: gofundme.com/f/help-thirsty-koalas-devastated-by-recent-fires

Taken from:

http://www.mygc.com.au/bushfire-relief-where-you-can-donate/

Thank you for your time.

Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway

Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway

https://www.hindawi.com/journals/ecam/2019/2971604/?utm_source=researcher_app&utm_medium=referral&utm_campaign=resr_mrkt_researcher_inbound

Exercise immunology: Future directions – ScienceDirect

Exercise immunology: Future directions – ScienceDirect

Highlights
• The immune system is responsive to the physiological stress imposed by the exercise workload.

• Technological advances now allow a systems biology approach to exercise immunology.

• The immune response to exercise is influenced by small-molecule metabolites and proteins.

• Immunometabolism has provided new insights into how metabolites influence immune function.

• Exercise has a modulating effect on gut microbial populations.

https://www.sciencedirect.com/science/article/pii/S2095254619301528

Centenarians: An excellent example of resilience for successful ageing – ScienceDirect

Centenarians: An excellent example of resilience for successful ageing – ScienceDirect

Highlights
• Centenarians maintain intrinsic capacity longer than individuals who display ordinary aging.

• Resilience is a determinant of health, and centenarians maintain it longer.

• Centenarians have specific genetic features.

https://www.sciencedirect.com/science/article/abs/pii/S0047637419302040

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation – ScienceDirect

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation – ScienceDirect

Highlights
• Tea-derived l-theanine inhibited AGE production in d-galactose-induced aging rats.

• l-Theanine increased FoxO1 expression and antioxidative enzymes in aged livers.

• l-Theanine could reduce oxygen free radicals and maintain the redox balance.

• l-Theanine supplementation could protect against age-related liver damage.

https://www.sciencedirect.com/science/article/pii/S0531556519306643

Role of High‐Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control | Journal of the American Heart Association

Role of High‐Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control | Journal of the American Heart Association

Emerging evidence (summarized in Table) indicates that HDL‐ and apoA‐I–targeted therapies are a potential option for conserving residual β‐cell function and improving insulin sensitivity in patients who are progressing toward, or have already developed, T1DM and T2DM. The recent failures of HDL‐raising agents in cardiovascular clinical outcome trials highlight the need to develop novel and innovative HDL‐targeted approaches to achieve these goals. Elucidating the mechanism(s) underlying the antidiabetic functions of HDLs and apoA‐I will also provide opportunities to identify and develop new HDL‐targeted therapies for diabetes mellitus. Achievement of these goals could be particularly advantageous for patients with T1DM for whom treatment options are currently limited to insulin replacement therapy, and for patients with T2DM that are refractory to currently available therapies.

Table 1.Role of HDL and apoA‐I in Glycemic Control, Insulin Sensitivity and β‐Cell Function
Topic Outcome Reference
Association of HDL‐C and apoA‐I levels with glycemic control
Subjects with T2DM Serum HDL‐C, apoA‐I, and HDL‐C/apoA‐I levels are inversely associated with insulin resistance by HOMA‐IR 9
Subjects with impaired glucose tolerance ApoA‐I level is an independent risk factor for glucose tolerance 10
HDL and apoA‐I in glucose disposal/insulin sensitivity
Primary human skeletal muscle cells ApoA‐I improves insulin‐dependent and ‐independent glucose uptake 27
C2C12 skeletal muscle cells ApoA‐I increases glucose uptake by phosphorylation of AMPK 35
High‐fat–fed C57BL/6 mice ApoA‐I improves insulin sensitivity by reducing systemic and hepatic inflammation 40
db/db mice Long‐term HDL infusion improves glucose tolerance by activating GSK‐3 and AMPK in skeletal muscle 37
Pregnant female Wistar rats ApoA‐I infusions increase insulin sensitivity, reduces systemic inflammation and protects against pregnancy‐induced insulin resistance 45
Subjects with T2DM A single rHDL infusion reduces plasma glucose levels by increasing insulin secretion and promoting glucose uptake in skeletal muscle 2
HDL and apoA‐I in β‐cell function
Min6 insulinoma cells HDLs isolated from normal human plasma, rHDLs, and apoA‐I increase Ins1 and Ins2 gene transcription and GSIS 58
Ins‐1E insulinoma cells ApoA‐I increases Pdx1 gene transcription and GSIS 57
βTC3 insulinoma cells Incubation with HDL protects βTC3 cells against LDL‐induced apoptosis 70
C57BL/6 mice ApoA‐I infusions increase insulin secretion and improve glucose tolerance 52
High‐fat–fed C57BL/6 mice Short‐term apoA‐I treatment increases GSIS and improves glucose clearance independent of insulin secretion 53
Mice with conditional deletion of ABCA1 and ABCG1 in β cells ApoA‐I infusions increase GSIS in islets isolated from mice with elevated islet cholesterol levels 54
Healthy subjects and Min6 cells CETP inhibition increases plasma HDL‐C, apoA‐I, and insulin levels in normal human subjects. Plasma from these subjects also increases GSIS in Min6 cells pretreated with oxidized LDLs 60
Isolated human islets HDL protects human islets against oxidized LDL‐induced apoptosis 71
Isolated human and mouse islets HDL protects human and mouse islets from interleukin‐1β– and glucose‐induced apoptosis 72
AMPK indicates adenosine monophosphate‐activated protein kinase; apoA‐I, apolipoprotein A‐I; CETP, cholesteryl ester transfer protein; GSIS, glucose‐stimulated insulin secretion; GSK, glycogen synthase kinase‐3; HDL, high‐density lipoprotein; HDL‐C, high‐density lipoprotein cholesterol; HOMA‐IR, Homeostatic model assessment of insulin resistance; LDL, low‐density lipoprotein; rHDL, reconstituted HDL.

https://www.ahajournals.org/doi/10.1161/JAHA.119.013531

CoQ 10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium | SpringerLink

CoQ 10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium | SpringerLink

“Four weeks of dietary CoQ10 in HM pigs enhances active, nuclear-bound PGC1α and increases the expression of ETC proteins within mitochondria of HM tissue.”

https://link.springer.com/article/10.1186/s12986-019-0418-8?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Reward does not facilitate visual perceptual learning until sleep occurs | PNAS

Reward does not facilitate visual perceptual learning until sleep occurs | PNAS

“First, we demonstrated a significantly larger offline performance gain over a 12-h interval including sleep in a reward group than that in a no-reward group. However, the offline performance gains over the 12-h interval without sleep were not significantly different with or without reward during training, indicating a crucial interaction between reward and sleep in VPL.”

https://www.pnas.org/content/early/2019/12/30/1913079117

The Vagus Nerve is Key to Well-Being | Elemental

The Vagus Nerve is Key to Well-Being | Elemental

“The vagus nerve, also called the “10th cranial nerve,” is the longest, largest, and most complex of the cranial nerves, and in some ways it’s also the least understood. Experts have linked its activity to symptom changes in people with migraine headaches, inflammatory bowel disease, depression, epilepsy, arthritis, and many other common ailments. The more science learns about the vagus nerve, the more it seems like a better understanding of its function could unlock new doors to treating all manner of human suffering.”

https://elemental.medium.com/science-confirms-that-the-vagus-nerve-is-key-to-well-being-c23fab90e211

Intermittent fasting: live ‘fast,’ live longer? | EurekAlert! Science News

Intermittent fasting: live ‘fast,’ live longer? | EurekAlert! Science News

“Mattson says studies have shown that this switch improves blood sugar regulation, increases resistance to stress and suppresses inflammation. Because most Americans eat three meals plus snacks each day, they do not experience the switch, or the suggested benefits.

In the article, Mattson notes that four studies in both animals and people found intermittent fasting also decreased blood pressure, blood lipid levels and resting heart rates.”

https://www.eurekalert.org/pub_releases/2019-12/jhm-ifl121819.php

Muscle wasting disease linked to defective mitochondrial energy and NAD+ biosynthesis pathways – Science Mission

Muscle wasting disease linked to defective mitochondrial energy and NAD+ biosynthesis pathways – Science Mission

“Moreover, results showed that sarcopenia was also associated with reduced levels of enzymes involved in the recycling of NAD+, which acts as a metabolic sensor in the cell and regulates energy production pathways.”

http://sciencemission.com/site/index.php?page=news&type=view&id=health-science%2Fmuscle-wasting-disease&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Overspill of fat shown to cause Type 2 Diabetes – Science Mission

Overspill of fat shown to cause Type 2 Diabetes – Science Mission

Fatty liver? You’re possibly one step away from type 2 diabetes.

Keep an eye on your ALT levels. Ask your doc for a lipid profile blood test and check it today!

http://sciencemission.com/site/index.php?page=news&type=view&id=obesity-diabetes%2Foverspill-of-fat-shown&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders | SpringerLink

Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders | SpringerLink

“Oleic acid affected the methylation of Pparγ and C/ebpα promoters, what correlated with higher expression. Furthermore, examined free fatty acids influenced the phenotype of mature adipocytes, especially insulin signaling pathway and adipokine secretion.”

https://link.springer.com/article/10.1186/s12944-019-1173-6?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Mitochondrial Haplogroups and Lifespan in a Population Isolate – ScienceDirect

Mitochondrial Haplogroups and Lifespan in a Population Isolate – ScienceDirect

“The lifespan-lengthening association was apparent in both sexes but only after the age of 60. Our results provide further support for the role of mitochondrial genetics in lengthening human lifespan.”

https://www.sciencedirect.com/science/article/abs/pii/S1567724919301047

Calorie restriction mimetics: Can you have your cake and eat it, too? – ScienceDirect

Calorie restriction mimetics: Can you have your cake and eat it, too? – ScienceDirect

Highlights
• We review the literature pertaining to calorie restriction mimetics (CRM).

• We discuss history, definitions, and applications of CRM.

• We discuss the concept of upstream and downstream targeting.

• We review the leading candidates for developing CRM.

• We suggest where the field is heading.

https://www.sciencedirect.com/science/article/pii/S1568163714001275

Why 80 Percent of New Year’s Resolutions Fail

A new year, and a new decade lay before us as we reach the end of 2019.

You’re inspired to start improving something about your health of life.

Don’t, well, more accurately do, but don’t do it for a new years resolution.

Do it because you are ready, do it because you’re done with the status quo, do it for your happiness, for your family.

Do it for any reason other than an arbitrary date with artificial importance projected upon it.

Changes are hard and habits are strong. It takes time and conviction to change so you need to be truly ready and you need to do it as soon as you can.

If you set yourself a new years resolution and fail you are likely to give up completely or revert back to comfort to relive the disappointment and depression that may follow a failed new years resolution.

Know that you have it in you to change without an arbitrary date. You can do it!

from:

https://health.usnews.com/health-news/blogs/eat-run/articles/2015-12-29/why-80-percent-of-new-years-resolutions-fail

Effect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials | SpringerLink

Effect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials | SpringerLink

“L-Cit supplementation significantly decreased non-resting brachial and aortic SBP. Brachial DBP was significantly lowered by L-Cit regardless of resting status. Given the relatively small number of available trials in the stratified analyses and the potential limitations of these trials, the present findings should be interpreted cautiously and need to be confirmed in future well-designed trials with a larger sample size.”

https://link.springer.com/article/10.1186/s12986-019-0415-y?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 + T-cell memory development | Nature Cell Biology

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 + T-cell memory development | Nature Cell Biology

“Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual metabolic program raises the question of how Pck1 is upregulated in CD8+ Tmem cells. Here, we show that mitochondrial acetyl coenzyme A is diverted to the ketogenesis pathway, which indirectly regulates Pck1 expression. Mechanistically, ketogenesis-derived β-hydroxybutyrate is present in CD8+ Tmem cells; β-hydroxybutyrate epigenetically modifies Lys 9 of histone H3 (H3K9) of Foxo1 and Ppargc1a (which encodes PGC-1α) with β-hydroxybutyrylation, upregulating the expression of these genes.”

https://www.nature.com/articles/s41556-019-0440-0?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Glutamine may decrease obesity-linked inflammation – Science Mission

Glutamine may decrease obesity-linked inflammation – Science Mission

“Glutamine could help people with obesity reduce inflammation of fat tissue and reduce fat mass, according to a new study. The researchers also show how glutamine levels can alter gene expression in several different cell types. However, more research is needed before glutamine supplementation may be recommended as a treatment for obesity. The study is published in the journal Cell Metabolism.”

http://sciencemission.com/site/index.php?page=news&type=view&id=obesity-diabetes%2Fglutamine-may-decrease&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Effects of Intermittent Fasting on Health, Aging, and Disease | NEJM

Effects of Intermittent Fasting on Health, Aging, and Disease | NEJM

“Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.”

https://www.nejm.org/doi/full/10.1056/NEJMra1905136

Longevity protein SIRT6 also protects against fatty liver and fatty liver disease – Science Mission

Longevity protein SIRT6 also protects against fatty liver and fatty liver disease – Science Mission

“Fatty liver, or hepatic steatosis, which develops when the body produces too much fat or doesn’t metabolize fat efficiently enough, affects around 25% of the global population. Excess fat is stored in liver cells, where it accumulates and can cause fatty liver and other diseases.

In a study just published in the journal Cell Reports, researchers reveal for the first time that SIRT6, a protein involved in regulating many biological processes such as aging, obesity, insulin resistance, inflammation and metabolism, also plays a crucial role in burning and regulating liver fat metabolism.”

http://sciencemission.com/site/index.php?page=news&type=view&id=health-science%2Flongevity-protein-sirt6&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27

Age and life expectancy clocks based on machine learning analysis of mouse frailty | bioRxiv

Age and life expectancy clocks based on machine learning analysis of mouse frailty | bioRxiv

“The identification of genes and interventions that slow or reverse aging is hampered by the lack of non-invasive metrics that can predict life expectancy of pre-clinical models. Frailty Indices (FIs) in mice are composite measures of health that are cost-effective and non-invasive, but whether they can accurately predict health and lifespan is not known. Here, mouse FIs were scored longitudinally until death and machine learning was employed to develop two clocks. ”

https://www.biorxiv.org/content/10.1101/2019.12.20.884452v1

AMPK Activation of Flavonoids from Psidium guajava Leaves in L6 Rat Myoblast Cells and L02 Human Hepatic Cells

AMPK Activation of Flavonoids from Psidium guajava Leaves in L6 Rat Myoblast Cells and L02 Human Hepatic Cells

“The findings demonstrated that quercetin and its glycosides from Psidium guajava leaves exhibited significant AMPK activity and were likely responsible for the antidiabetic effect of Psidium guajava leaves”

https://www.hindawi.com/journals/ecam/2019/9209043/?utm_source=researcher_app&utm_medium=referral&utm_campaign=resr_mrkt_researcher_inbound

Effects of sleep duration and weekend catch-up sleep on falling injury in adolescents: a population-based study – ScienceDirect

Effects of sleep duration and weekend catch-up sleep on falling injury in adolescents: a population-based study – ScienceDirect

Highlights
• Insufficient sleep is well known to be an important risk factor for falls.

• The effect of weekend catch-up sleep on falls has not been studied in adolescents.

• Short sleep duration was found to be a major risk factor for falls in adolescents.

• Longer sleep duration may reduce the risk of falls among adolescents.

• Longer weekend catch-up sleep may have a protective effect against falls.

https://www.sciencedirect.com/science/article/abs/pii/S1389945719316569

Antioxidant, antimicrobial and cytotoxic properties of four different extracts derived from the roots of Nicotianatabacum L. – ScienceDirect

Antioxidant, antimicrobial and cytotoxic properties of four different extracts derived from the roots of Nicotianatabacum L. – ScienceDirect

“In the current study we demonstrate for the first time that organic extracts derived from the roots of N. tabacum possessed antioxidant, anticancer and antimicrobial properties. Our data draws attention to N. tabacum as a promising source of bioactive molecules that can be utilized in pharmaceutical industry, despite the fact that tobacco smoking is a major risk factor for lung cancer.”

https://www.sciencedirect.com/science/article/pii/S187638201930914X

Reciprocal Effects Between Loneliness and Sleep Disturbance in Older Americans – Sarah C. Griffin, Allison Baylor Williams, Samantha N. Mladen, Paul B. Perrin, Joseph M. Dzierzewski, Bruce D. Rybarczyk,

Reciprocal Effects Between Loneliness and Sleep Disturbance in Older Americans – Sarah C. Griffin, Allison Baylor Williams, Samantha N. Mladen, Paul B. Perrin, Joseph M. Dzierzewski, Bruce D. Rybarczyk,

“Higher loneliness correlated with higher sleep disturbance at baseline. There was evidence of reciprocal effects between loneliness and sleep across timepoints. These associations overall remained when accounting for demographics, objective isolation, and depression.”

https://journals.sagepub.com/doi/abs/10.1177/0898264319894486

Evidence-Based Eating Guide | NutritionFacts.org

Evidence-Based Eating Guide | NutritionFacts.org

The Evidence-Based Eating Guide: A Healthy Living Resource from Dr. Greger & NutritionFacts.org is a tool designed to help make the switch to a healthier lifestyle more simple. It’s an easy to understand guide with applicable information for eating healthier, including a breakdown of Dr. Greger’s Traffic Light Eating, tips for using Dr. Greger’s Daily Dozen checklist, sample menus, and more.

https://nutritionfacts.org/healthkit/

The State of Ageing in 2019: Adding life to our years | Centre for Ageing Better

The State of Ageing in 2019: Adding life to our years | Centre for Ageing Better

How prepared is society for our longer lives? Our new report, ‘The State of Ageing in 2019’, uses publicly available data to give a snapshot of what life is like for people aged 65 and older today. It also investigates the prospects for people currently in their 50s and 60s looking across four crucial areas: work and finances, housing, health and communities.

The State of Ageing in 2019: Adding life to our years

https://www.ageing-better.org.uk/publications/state-of-ageing-2019

Weight for it: Time-restricted eating benefits those at risk for diabetes, heart disease | EurekAlert! Science News

Weight for it: Time-restricted eating benefits those at risk for diabetes, heart disease | EurekAlert! Science News

“The pilot study, published online in the December 5, 2019 edition of Cell Metabolism, found that when participants restricted their eating to 10 hours or less over a period of 12 weeks, they lost weight, reduced abdominal fat, lowered blood pressure and cholesterol and enjoyed more stable blood sugar and insulin levels.”

https://www.eurekalert.org/pub_releases/2019-12/uoc–wfi120519.php

Senescent cell turnover slows with age providing an explanation for the Gompertz law | Nature Communications

Senescent cell turnover slows with age providing an explanation for the Gompertz law | Nature Communications

“A causal factor in mammalian aging is the accumulation of senescent cells (SnCs). SnCs cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their importance, turnover rates of SnCs are unknown, and their connection to aging dynamics is unclear. Here we use longitudinal SnC measurements and induction experiments to show that SnCs turn over rapidly in young mice, with a half-life of days, but slow their own removal rate to a half-life of weeks in old mice.”

https://www.nature.com/articles/s41467-019-13192-4

Anti-inflammatory, analgesic and acute toxicity effects of fermented soybean | BMC Complementary and Alternative Medicine | Full Text

Anti-inflammatory, analgesic and acute toxicity effects of fermented soybean | BMC Complementary and Alternative Medicine | Full Text

NESTE is a nutritious food ingredient with potential anti-inflammatory and analgesic effects.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-019-2791-2

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies – ScienceDirect

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies – ScienceDirect

Highlights
•
From meta-analysis of RCTs in Alzheimer’s disease and Mild Cognitive Impairment, oral Medium Chain Triglycerides administration induced mild peripheral ketosis

•
From meta-analysis of RCTs in Alzheimer’s disease and Mild Cognitive Impairment, oral Medium Chain Triglycerides administration improved cognition on a combined scale of ADAS-Cog and MMSE.

•
Risk of bias of existing studies of RCTs in Alzheimer’s disease and Mild Cognitive Impairment necessitates future trials.

https://www.sciencedirect.com/science/article/pii/S156816371930131X

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21 – ScienceDirect

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21 – ScienceDirect

“In this study, we showed that overexpression of KLF2 induced the senescence of pancreatic cancer cells and inhibited tumorigenesis, and knockdown of KLF2 inhibited senescence and p21 expression. In the molecular mechanism study, KLF2 was found to interact with FOXO4 and cooperated with FOXO4 to induce the expression of p21.”

https://www.sciencedirect.com/science/article/pii/S001448271930669X

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer’s disease models – Song – – Aging Cell – Wiley Online Library

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer’s disease models – Song – – Aging Cell – Wiley Online Library

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13069?utm_campaign=RESR_MRKT_Researcher_inbound&af=R&utm_medium=referral&utm_source=researcher_app

Frontiers | Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile | Physiology

Frontiers | Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile | Physiology


” Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-glycosylation of immunoglobulin G (IgG) and total plasma proteins was previously shown to reflect changes in inflammatory pathways, which could provide valuable information to further clarify exercise effects. In order to further expand the understanding of the relationship between physical activity and inflammation, we examined the effect of intense exercise, in the form of repeated sprint training (RST), on IgG and total plasma proteins N-glycosylation in combination with traditionally used inflammation markers: C-reactive protein (CRP), interleukin 6 (IL-6), and leukocyte count.

https://www.frontiersin.org/articles/10.3389/fphys.2019.01522/full?utm_source=researcher_app&utm_medium=referral&utm_campaign=RESR_MRKT_Researcher_inbound

Theme: Overlay by Kaira Extra Text
Cape Town, South Africa